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Is the expression of placental epithelial and lymphoid markers associated with the perinatal outcomes in preeclampsia?
, 2
Affiliations- Department od Pathology Konya Education and Research Hospital, Konya, Türkiye
- Department of Perinatology, KTO Karatay University, Konya, Türkiye
open access
Abstract
Objectives: This study aimed to investigate the association of the epithelial and lymphoid immune markers with the adverse perinatal conditions such as early-onset preeclampsia (EOPE), fetal growth restriction (FGR) and intrauterine fetal death (IUFD) in preeclampsia in the placentae of preeclamptic patients.
Material and methods: A total of 60 pregnant patients were included in this study. The immunohistochemistry method was used to determine the expression levels of CD4, CD8, CD4 / CD8, CD68, P53, MDM2, CK18, CK19, E-cadherin, and β catenin.
Results: In our study, the increase in E-cadherin expression in the preeclamptic fetal-maternal placental region was associated with EOPE and FGR development preeclampsia and the decrease in the expression of CD4 and CD8, which are involved in the local immunomodulation, was associated with IUFD.
Conclusions: Our data reveal that the increase in the expression of CK18, CK19, E-cadherin, and β-catenin and the decrease in CD4 and CD8 play a role in the pathogenesis of preeclampsia.
Abstract
Objectives: This study aimed to investigate the association of the epithelial and lymphoid immune markers with the adverse perinatal conditions such as early-onset preeclampsia (EOPE), fetal growth restriction (FGR) and intrauterine fetal death (IUFD) in preeclampsia in the placentae of preeclamptic patients.
Material and methods: A total of 60 pregnant patients were included in this study. The immunohistochemistry method was used to determine the expression levels of CD4, CD8, CD4 / CD8, CD68, P53, MDM2, CK18, CK19, E-cadherin, and β catenin.
Results: In our study, the increase in E-cadherin expression in the preeclamptic fetal-maternal placental region was associated with EOPE and FGR development preeclampsia and the decrease in the expression of CD4 and CD8, which are involved in the local immunomodulation, was associated with IUFD.
Conclusions: Our data reveal that the increase in the expression of CK18, CK19, E-cadherin, and β-catenin and the decrease in CD4 and CD8 play a role in the pathogenesis of preeclampsia.
Keywords
E-cadherin; CD4; CD8; β-catenin; early onset preeclampsia; adverse perinatal outcomes
About this articleTitle
Is the expression of placental epithelial and lymphoid markers associated with the perinatal outcomes in preeclampsia?
Journal
Issue
Article type
Research paper
Pages
929-938
Published online
2023-03-15
Page views
303
Article views/downloads
264
DOI
Pubmed
Bibliographic record
Ginekol Pol 2023;94(11):929-938.
Keywords
E-cadherin
CD4
CD8
β-catenin
early onset preeclampsia
adverse perinatal outcomes
Authors
Zeynep Bayramoğlu
Sibel Özler
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