open access

Vol 94, No 1 (2023)
Other materials agreed with the Editors
Published online: 2023-01-31
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Molecular classification in endometrial cancer — are we ready?

Agnieszka Rychlik1, Mariusz Bidzinski1
·
Pubmed: 36748253
·
Ginekol Pol 2023;94(1):1-2.
Affiliations
  1. Department of Gynecologic Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

open access

Vol 94, No 1 (2023)
EDITORIAL
Published online: 2023-01-31

Abstract

Not available

Abstract

Not available
Get Citation
About this article
Title

Molecular classification in endometrial cancer — are we ready?

Journal

Ginekologia Polska

Issue

Vol 94, No 1 (2023)

Article type

Other materials agreed with the Editors

Pages

1-2

Published online

2023-01-31

Page views

3065

Article views/downloads

406

DOI

10.5603/GP.a2023.0006

Pubmed

36748253

Bibliographic record

Ginekol Pol 2023;94(1):1-2.

Authors

Agnieszka Rychlik
Mariusz Bidzinski

References (16)
  1. Kandoth C, Schultz N, Cherniack AD, et al. Cancer Genome Atlas Research Network. Integrated genomic characterization of endometrial carcinoma. Nature. 2013; 497(7447): 67–73.
  2. Talhouk A, Hoang LN, McConechy MK, et al. Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment. Gynecol Oncol. 2016; 143(1): 46–53.
  3. Talhouk A, McConechy MK, Leung S, et al. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015; 113(2): 299–310.
  4. Talhouk A, McConechy MK, Leung S, et al. Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer. Cancer. 2017; 123(5): 802–813.
  5. Stelloo E, Bosse T, Nout RA, et al. Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a TransPORTEC initiative. Mod Pathol. 2015; 28(6): 836–844.
  6. Bayramoglu D, Seçilmiş Kerimoğlu Ö, Bayramoğlu Z, et al. Classification of high-grade endometrium carcinomas using molecular and immunohistochemical methods. Ginekol Pol. 2022 [Epub ahead of print].
  7. Concin N, Matias-Guiu X, Vergote I, et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer. 2021; 31(1): 12–39.
  8. Marabelle A, Le DT, Ascierto PA, et al. Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study. J Clin Oncol. 2020; 38(1): 1–10.
  9. Oaknin A, Tinker A, Gilbert L, et al. Clinical Activity and Safety of the Anti–Programmed Death 1 Monoclonal Antibody Dostarlimab for Patients With Recurrent or Advanced Mismatch Repair–Deficient Endometrial Cancer. JAMA Oncology. 2020; 6(11): 1766.
  10. Fader AN, Roque DM, Siegel E, et al. Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu. J Clin Oncol. 2018; 36(20): 2044–2051.
  11. Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program. International Journal of Gynecologic Cancer. 2022; 33(1): 109–117.
  12. van den Heerik AS, Horeweg N, Nout RA, et al. PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer. Int J Gynecol Cancer. 2020; 30(12): 2002–2007.
  13. León-Castillo A, de Boer SM, Powell ME, et al. TransPORTEC consortium. Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy. J Clin Oncol. 2020; 38(29): 3388–3397.
  14. Bartosch C, Clarke B, Bosse T. Gynaecological neoplasms in common familial syndromes (Lynch and HBOC). Pathology. 2018; 50(2): 222–237.
  15. Mur P, García-Mulero S, Del Valle J, et al. Role of POLE and POLD1 in familial cancer. Genet Med. 2020; 22(12): 2089–2100.
  16. Bidzinski M, Danska-Bidzinska A, Rychlik A, et al. Molecular classification of endometrial carcinoma, is it the new era of precision medicine? Ginekologia Polska. 2022; 93(2): 163–167.

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