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Published online: 2023-02-08
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Smooth muscle tumor of uncertain malignant potential (STUMP): a case-based analysis

Caglar Helvacioglu1, Mustafa Eroğlu2, Cem Yalçınkaya1, Cumhur Selcuk Topal3, Işıl Ada Akgul1, Sumeyye Cimenli1, İbrahim Kale1
Affiliations
  1. Department of Obstetrics and Gynecology, Maternal-Fetal Unit, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Türkiye
  2. Department of Obstetrics and Gynecology, Health Sciences University Zeynep Kamil Women and Children’s Diseases Training and Research Hospital, İstanbul, Türkiye
  3. Department of Pathology, Umraniye Training and Research Hospital, Istanbul, Turkey

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2023-02-08

Abstract

Objectives: The present study aimed to analyze of uterine smooth muscle tumors of uncertain malignant potential (STUMP) and the outcomes of patients with STUMP.

Material and methods: In this retrospective study, the data of patients diagnosed with STUMP in a single tertiary center between January 2005–January 2020 were reviewed. We assessed the demographic variables, treatment outcomes, time until recurrence, disease-free and overall survival of the patients.

Results: Twenty-five patients diagnosed with STUMP were included in the study. The mean age of the patients was 43.2 ± 10.3 years. Thirteen of the 25 patients (52%) were treated by myomectomy, others received diagnoses following hysterectomy. The median follow-up time was 45.2 months. Recurrence was observed in three cases (12%), two of which were followed up without hysterectomy, and the third patient died by peritonitis carcinomatosa 60 months after diagnosis although she received cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment.

Conclusions: This study evaluates the data of patients with STUMP. Our results reveal a STUMP recurrence of 12%, like those previously reported in the literature. Despite the possibility of malignant recurrence, fertility-preserving treatment with close follow-up should be tried, because of the relatively early age at diagnosis.

Abstract

Objectives: The present study aimed to analyze of uterine smooth muscle tumors of uncertain malignant potential (STUMP) and the outcomes of patients with STUMP.

Material and methods: In this retrospective study, the data of patients diagnosed with STUMP in a single tertiary center between January 2005–January 2020 were reviewed. We assessed the demographic variables, treatment outcomes, time until recurrence, disease-free and overall survival of the patients.

Results: Twenty-five patients diagnosed with STUMP were included in the study. The mean age of the patients was 43.2 ± 10.3 years. Thirteen of the 25 patients (52%) were treated by myomectomy, others received diagnoses following hysterectomy. The median follow-up time was 45.2 months. Recurrence was observed in three cases (12%), two of which were followed up without hysterectomy, and the third patient died by peritonitis carcinomatosa 60 months after diagnosis although she received cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment.

Conclusions: This study evaluates the data of patients with STUMP. Our results reveal a STUMP recurrence of 12%, like those previously reported in the literature. Despite the possibility of malignant recurrence, fertility-preserving treatment with close follow-up should be tried, because of the relatively early age at diagnosis.

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Keywords

uterus; leiomyoma; smooth muscle tumor; sarcoma

About this article
Title

Smooth muscle tumor of uncertain malignant potential (STUMP): a case-based analysis

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2023-02-08

Page views

406

Article views/downloads

395

DOI

10.5603/GP.a2023.0005

Pubmed

36929786

Keywords

uterus
leiomyoma
smooth muscle tumor
sarcoma

Authors

Caglar Helvacioglu
Mustafa Eroğlu
Cem Yalçınkaya
Cumhur Selcuk Topal
Işıl Ada Akgul
Sumeyye Cimenli
İbrahim Kale

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