open access

Vol 94, No 4 (2023)
Research paper
Published online: 2022-10-10
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Endometrial carcinoma in patients under 40 years of age: insights from the Bulgarian Cancer Registry

Angel Yordanov1, Stoyan Kostov2, Yavor Kornovski23, Stanislav Slavchev23, Yonka Ivanova23, Jean Calleja-Agius4, Riccardo Di Fiore45, Sherif Suleiman4, Andra Piciu6, Ihsan Hasan7, Mariela Vasileva-Slaveva89
·
Pubmed: 37431249
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Ginekol Pol 2023;94(4):275-282.
Affiliations
  1. Department of Gynecologic Oncology, Medical University Pleven, Bulgaria
  2. Obstetrics and Gynecology Clinic, St. Anna University Hospital, Varna, Bulgaria
  3. Medical University of Varna, Bulgaria
  4. Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
  5. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, USA
  6. Department of Medical Oncology “luliu Hatieganu”, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  7. Department of Obstetrics and Gynecology, University Hospital ”Sofiamed“, Sofia, Bulgaria
  8. Department of Breast Surgery, Shterev Hospital, Sofia, Bulgaria
  9. Medical University Pleven, Research Institute, Pleven, Bulgaria

open access

Vol 94, No 4 (2023)
ORIGINAL PAPERS Gynecology
Published online: 2022-10-10

Abstract

Objectives: We aimed to investigate the overall survival (OS) of young women with endometrial cancer (EC) in Bulgaria and the impact of histological type on survival.
Material and methods: This is a population-wide retrospective study of patients with EC (≤ 40 years at diagnosis) registered at Bulgarian National Cancer Registry (BNCR) between 1993 and 2020. Patients were re-classified according to the 8th edition of the TNM classification.
Results: In total, 30 597 patients were registered and histologically confirmed with malignant tumors of the uterine body. From that, 29 065 of them (95%) had ECs, and the rest had sarcomas. Around 1.64% of all malignant tumors of the uterine body are diagnosed in women under the age of 40. Most of them are diagnosed in the early stage. There was no significant difference in median OS for patients diagnosed before or after 2003. In recent years there was a slight improvement in survival and patients from the last cohort of this study had a 5-year survival rate of 92.5%. Patients with favorable pathology (T1, G1/2) had no lymph node involvement at the time of diagnosis and their 10-year survival rate was 94%.
Conclusions: EC in young women is a rare disease. In most cases, patients are diagnosed in early stageT1, G1/2, N0 and their prognosis is excellent. However, the lack of improvement of OS of young patients with EC in the last three decades shows the need for treatment optimization.

Abstract

Objectives: We aimed to investigate the overall survival (OS) of young women with endometrial cancer (EC) in Bulgaria and the impact of histological type on survival.
Material and methods: This is a population-wide retrospective study of patients with EC (≤ 40 years at diagnosis) registered at Bulgarian National Cancer Registry (BNCR) between 1993 and 2020. Patients were re-classified according to the 8th edition of the TNM classification.
Results: In total, 30 597 patients were registered and histologically confirmed with malignant tumors of the uterine body. From that, 29 065 of them (95%) had ECs, and the rest had sarcomas. Around 1.64% of all malignant tumors of the uterine body are diagnosed in women under the age of 40. Most of them are diagnosed in the early stage. There was no significant difference in median OS for patients diagnosed before or after 2003. In recent years there was a slight improvement in survival and patients from the last cohort of this study had a 5-year survival rate of 92.5%. Patients with favorable pathology (T1, G1/2) had no lymph node involvement at the time of diagnosis and their 10-year survival rate was 94%.
Conclusions: EC in young women is a rare disease. In most cases, patients are diagnosed in early stageT1, G1/2, N0 and their prognosis is excellent. However, the lack of improvement of OS of young patients with EC in the last three decades shows the need for treatment optimization.

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Keywords

endometrial cancer; young women; rare diagnosis; epidemiology; incidence rates; survival

About this article
Title

Endometrial carcinoma in patients under 40 years of age: insights from the Bulgarian Cancer Registry

Journal

Ginekologia Polska

Issue

Vol 94, No 4 (2023)

Article type

Research paper

Pages

275-282

Published online

2022-10-10

Page views

2217

Article views/downloads

556

DOI

10.5603/GP.a2022.0106

Pubmed

37431249

Bibliographic record

Ginekol Pol 2023;94(4):275-282.

Keywords

endometrial cancer
young women
rare diagnosis
epidemiology
incidence rates
survival

Authors

Angel Yordanov
Stoyan Kostov
Yavor Kornovski
Stanislav Slavchev
Yonka Ivanova
Jean Calleja-Agius
Riccardo Di Fiore
Sherif Suleiman
Andra Piciu
Ihsan Hasan
Mariela Vasileva-Slaveva

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