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The analysis of coexistence of celiac disease and vulvar lichen sclerosus in girls
, 1, 2, 1, 1, 1
Affiliations- Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia in Katowice, Poland
- Euroimmun Polska Sp. z o.o., Wroclaw, Poland
open access
Abstract
Objectives: Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease of unclear etiology. Recent studies show that 15–34% of cases in adult women and 14% in girls coexist with allergies or autoimmune diseases, among others — celiac disease (CD). Most of the research on the coexistence of VLS and autoimmune diseases has been carried out on a group of adult women. Literature data on this issue are very scarce.
Material and methods: The presented work is a pioneering project in which we tried to elucidate a possible relationship between celiac disease and lichen sclerosus in girls. The aim of the research was to study the antibodies characteristic of celiac disease in girls with VLS. The control group consisted of 35 heathy adolescent girls and the study group consisted
of 20 girls aged 2–18 years old diagnosed with vulvar lichen sclerosus recruited at the Gynecological Clinic for Girls at the Women’s Health Center in Katowice.
Results: There were no significant differences in the concentrations of antibodies characteristic for CD in the blood serum between the studied groups.
Conclusions: The main limitation of our study was the small size of the study group. It is therefore legitimate to conduct further research on a larger study group to find themutual correlations between the analyzed antibodies and the onset and the course of VLS in girls. The finding of a positive correlation between the coexistence of VLS and CD may prevent potentially serious, long-term complications.
Abstract
Objectives: Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease of unclear etiology. Recent studies show that 15–34% of cases in adult women and 14% in girls coexist with allergies or autoimmune diseases, among others — celiac disease (CD). Most of the research on the coexistence of VLS and autoimmune diseases has been carried out on a group of adult women. Literature data on this issue are very scarce.
Material and methods: The presented work is a pioneering project in which we tried to elucidate a possible relationship between celiac disease and lichen sclerosus in girls. The aim of the research was to study the antibodies characteristic of celiac disease in girls with VLS. The control group consisted of 35 heathy adolescent girls and the study group consisted
of 20 girls aged 2–18 years old diagnosed with vulvar lichen sclerosus recruited at the Gynecological Clinic for Girls at the Women’s Health Center in Katowice.
Results: There were no significant differences in the concentrations of antibodies characteristic for CD in the blood serum between the studied groups.
Conclusions: The main limitation of our study was the small size of the study group. It is therefore legitimate to conduct further research on a larger study group to find themutual correlations between the analyzed antibodies and the onset and the course of VLS in girls. The finding of a positive correlation between the coexistence of VLS and CD may prevent potentially serious, long-term complications.
Keywords
vulvar lichen sclerosus; celiac disease; adolescent
About this articleTitle
The analysis of coexistence of celiac disease and vulvar lichen sclerosus in girls
Journal
Issue
Article type
Research paper
Pages
793-798
Published online
2022-10-10
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4228
Article views/downloads
942
DOI
Pubmed
Bibliographic record
Ginekol Pol 2022;93(10):793-798.
Keywords
vulvar lichen sclerosus
celiac disease
adolescent
Authors
Kacper Nizinski
Dominika Orszulak
Marta Janik
Kaja Skowronek
Rafal Stojko
Agnieszka Drosdzol-Cop
References (34)- Jensen LS, Bygum A. Childhood lichen sclerosus is a rare but important diagnosis. Dan Med J. 2012; 59(5): A4424.
- Powell JJ, Wojnarowska F. Lichen sclerosus. Lancet. 1999; 353(9166): 1777–1783.
- Wallace HJ. Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc. 1971; 57(1): 9–30.
- Ismail D, Owen CM. Paediatric vulval lichen sclerosus: a retrospective study. Clin Exp Dermatol. 2019; 44(7): 753–758.
- Folk JE, Finlayson JS. The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases. Adv Protein Chem. 1977; 31: 1–133.
- Gujral N, Freeman HJ, Thomson ABR. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012; 18(42): 6036–6059.
- Proost S, Schlumberger W, Meyer W, et al. EUROIMMUN AG. Europlus - eine Biochip-Kombination aus Gewebeschnitten und Einzelantigenen für die indirekte Immunfluoreszenz: Endomysium/Gliadin, AMA/M2 und Parietalzellen/Intrinsic-Faktor. Poster zum Kongress für Laboratoriumsmedizin 1996 der Deutschen Gesellschaften für Laboratoriumsmedizin und für Klinische Chemie, 17. bis 20. November 1996 in Düsseldorf. J Lab Med. 1996; 20: 670.
- Howard A, Dean D, Cooper S, et al. Circulating basement membrane zone antibodies are found in lichen sclerosus of the vulva. Australas J Dermatol. 2004; 45(1): 12–15.
- Oyama N, Chan I, Neill SM, et al. Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet. 2003; 362(9378): 118–123.
- Morrel B, Ewing-Graham PC, van der Avoort IAM, et al. Structured analysis of histopathological characteristics of vulvar lichen sclerosus in a juvenile population. Hum Pathol. 2020; 106: 23–31.
- Azurdia RM, Luzzi GA, Byren I, et al. Lichen sclerosus in adult men: a study of HLA associations and susceptibility to autoimmune disease. Br J Dermatol. 1999; 140(1): 79–83.
- Simpkin S, Oakley A. Clinical review of 202 patients with vulval lichen sclerosus: a possible association with psoriasis. Australas J Dermatol. 2007; 48(1): 28–31.
- Kreuter A, Kryvosheyeva Y, Terras S, et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol. 2013; 93(2): 238–241.
- Harrington CI, Dunsmore IR. An investigation into the incidence of auto-immune disorders in patients with lichen sclerosus and atrophicus. Br J Dermatol. 1981; 104(5): 563–566.
- Cooper SM, Ali I, Baldo M, et al. The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study. Arch Dermatol. 2008; 144(11): 1432–1435.
- Marren P, Yell J, Charnock FM, et al. The association between lichen sclerosus and antigens of the HLA system. Br J Dermatol. 1995; 132(2): 197–203.
- Meyrick Thomas RH, Ridley CM, McGibbon DH, et al. Lichen sclerosus et atrophicus and autoimmunity--a study of 350 women. Br J Dermatol. 1988; 118(1): 41–46.
- Virgili A, Borghi A, Toni G, et al. Prospective clinical and epidemiologic study of vulvar lichen sclerosus: analysis of prevalence and severity of clinical features, together with historical and demographic associations. Dermatology. 2014; 228(2): 145–151.
- Edmonds EVJ, Hunt S, Hawkins D, et al. Clinical parameters in male genital lichen sclerosus: a case series of 329 patients. J Eur Acad Dermatol Venereol. 2012; 26(6): 730–737.
- Kantere D, Alvergren G, Gillstedt M, et al. Clinical features, complications and autoimmunity in male lichen sclerosus. Acta Derm Venereol. 2017; 97(3): 365–369.
- Tran DA, Tan X, Macri CJ, et al. Lichen Sclerosus: an autoimmunopathogenic and genomic enigma with emerging genetic and immune targets. Int J Biol Sci. 2019; 15(7): 1429–1439.
- Balakirski G, Grothaus J, Altengarten J, et al. Paediatric lichen sclerosus: a systematic review of 4516 cases. Br J Dermatol. 2020; 182(1): 231–233.
- Bieber AK, Steuer AB, Melnick LE, et al. Autoimmune and dermatologic conditions associated with lichen sclerosus. J Am Acad Dermatol. 2021; 85(1): 228–229.
- Ludvigsson JF, Murray JA. Epidemiology of celiac disease. Gastroenterol Clin North Am. 2019; 48(1): 1–18.
- Catassi C, Gatti S, Fasano A, et al. The new epidemiology of celiac disease. J Pediatr Gastroenterol Nutr. 2014; 59 Suppl 1: S7–S9.
- Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019; 7(5): 583–613.
- Rubio-Tapia A, Van Dyke CT, Lahr BD, et al. Predictors of family risk for celiac disease: a population-based study. Clin Gastroenterol Hepatol. 2008; 6(9): 983–987.
- Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families. Am J Gastroenterol. 2003; 98(2): 377–381.
- Mulder CJJ, Cellier C. Coeliac disease: changing views. Best Pract Res Clin Gastroenterol. 2005; 19(3): 313–321.
- Jacobs L, Gilliam A, Khavari N, et al. Association between lichen sclerosus and celiac disease: a report of three pediatric cases. Pediatr Dermatol. 2014; 31(6): e128–e131.
- Addolorato G, Parente A, de Lorenzi G, et al. Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literature. Digestion. 2003; 68(1): 9–12.
- Fasano A. Systemic autoimmune disorders in celiac disease. Curr Opin Gastroenterol. 2006; 22(6): 674–679.
- Kupfer SS, Jabri B. Pathophysiology of celiac disease. Gastrointest Endosc Clin N Am. 2012; 22(4): 639–660.
- Rodríguez-García C, González-Hernández S, Pérez-Robayna N, et al. Repigmentation of vitiligo lesions in a child with celiac disease after a gluten-free diet. Pediatr Dermatol. 2011; 28(2): 209–210.
