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Effects of polyamine synthesis enzymes on angiogenesis and apoptosis during endometriosis
, 1, 1, 2, 3
Affiliations- Cumhuriyet University, Turkey, Türkiye
- Okan University Faculty of Medicine Department of Biochemistry, Istanbul, Türkiye
- Erzincan Binali Yildirim University, Erzincan, Turkey
open access
Abstract
Objectives: Since we assumed that endometriosis is a benign cell division disorder, our study was conducted to investigate the effects of the relationships between polyamine synthesis and angiogenesis in the formation of endometriosis. Material and methods: Thirty-five patients with endometriosis and 35 healthy female women were included in the study. The patient and the control groups were compared regarding the blood levels of agmatine, argininecarboxylase (ADC), ornithinecarboxylase (ODC), agmatinase, arginase, ornithine, and the vascular endothelial growth factor (VEGF). Results: There is a statistically significant difference between the patient and the control groups regarding the agmatinase, arginase and VEGF levels (higher in the patient group) (p < 0.05). There is no statistically significant difference between the patient and the control groups regarding the ODC, ornithine and the ADC levels (p > 0.05). There is a statistically significant difference between the patient and the control groups regarding the agmatine levels (higher in the control group) (p < 0.05). Conclusions: The increase in the serum levels of polyamine synthesis enzymes may contribute to the formation of endometriosis. It is anticipated that the study of the relationship between enzymes and molecules in the polyamine synthesis pathway and angiogenesis in patients with endometriosis will contribute to the literature.
Abstract
Objectives: Since we assumed that endometriosis is a benign cell division disorder, our study was conducted to investigate the effects of the relationships between polyamine synthesis and angiogenesis in the formation of endometriosis. Material and methods: Thirty-five patients with endometriosis and 35 healthy female women were included in the study. The patient and the control groups were compared regarding the blood levels of agmatine, argininecarboxylase (ADC), ornithinecarboxylase (ODC), agmatinase, arginase, ornithine, and the vascular endothelial growth factor (VEGF). Results: There is a statistically significant difference between the patient and the control groups regarding the agmatinase, arginase and VEGF levels (higher in the patient group) (p < 0.05). There is no statistically significant difference between the patient and the control groups regarding the ODC, ornithine and the ADC levels (p > 0.05). There is a statistically significant difference between the patient and the control groups regarding the agmatine levels (higher in the control group) (p < 0.05). Conclusions: The increase in the serum levels of polyamine synthesis enzymes may contribute to the formation of endometriosis. It is anticipated that the study of the relationship between enzymes and molecules in the polyamine synthesis pathway and angiogenesis in patients with endometriosis will contribute to the literature.
Keywords
angiogenesis; apoptosis; endometriosis; polyamine
About this articleTitle
Effects of polyamine synthesis enzymes on angiogenesis and apoptosis during endometriosis
Journal
Issue
Article type
Research paper
Pages
89-94
Published online
2022-10-10
Page views
2848
Article views/downloads
423
DOI
Bibliographic record
Ginekol Pol 2023;94(2):89-94.
Keywords
angiogenesis
apoptosis
endometriosis
polyamine
Authors
Caglar Yildiz
Veysel Kenan Celik
Begum Kurt
Serkan Kapancık
Hasan Kılıcgun
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