open access

Vol 94, No 8 (2023)
Research paper
Published online: 2022-10-07
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Serum MOTS-c levels remain unchanged in patients with preeclampsia

Abdullah Tok1, Ozer Serdar2, Omer Faruk Kandilcik2, Filiz Alkan-Baylan3
·
Ginekol Pol 2023;94(8):633-637.
Affiliations
  1. Department of Obstetrics and Gynecology, Kahramanmaraş Sütçü İmam University Hospital, Kahramanmaras, Turkey
  2. Department of Obstetrics and Gynecology, Kahramanmaraş Pazarcık State Hospital, Kahramanmaras, Turkey
  3. Department of Biochemistry, Kahramanmaraş Sütçü İmam University Hospital, Kahramanmaras, Turkey

open access

Vol 94, No 8 (2023)
ORIGINAL PAPERS Obstetrics
Published online: 2022-10-07

Abstract

Objectives: Mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c) is a mitochondrial derived peptide which has beneficial effects on muscle metabolism, insulin sensitivity, weight regulation, and bone mineral density. This study aims to investigate whether serum levels of MOTS-c are altered in patients with preeclampsia.

Material and methods: This is cross sectional a case-control study of 30 patients with uncomplicated pregnancy, 30 patients with mild preeclampsia and 30 patients with severe preeclampsia that were admitted to the study center between June 2020 and January 2021.

Results: When compared to the healthy controls and patients with mild preeclampsia, maternal smoking was significantly more frequent, systolic and diastolic blood pressures were significantly higher and platelet count was significantly lower in patients with severe preeclampsia (p = 0.045, p = 0.0001, p = 0.0001 and p = 0.024 respectively). Serum MOTS-c concentrations were statistically similar in healthy controls, mild and severe preeclampsia patients (159.1 ± 28.7 ng/mL vs 129.6 ± 54.7 ng/mL vs 146.4 ± 48.3, p = 0.166). When compared to the healthy controls, systolic and diastolic blood pressures were significantly higher and platelet count was significantly lower in patients with late onset preeclampsia (p = 0.0001, p = 0.0001 and p = 0.022 respectively). Healthy controls and patients with early and late onset preeclampsia were statistically similar with respect to MOTS-c levels (159.1 ± 28.7 ng/mL vs 126.7 ± 56.9 vs 153.7 ± 39.8, p = 0.102).

Conclusions: This study failed to detect any significant relationship between MOTS-c and preeclampsia. Large scale research is needed to clarify if MOTS-c is a novel biomarker for preeclampsia and therapeutic target for preeclampsia patients.

Abstract

Objectives: Mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c) is a mitochondrial derived peptide which has beneficial effects on muscle metabolism, insulin sensitivity, weight regulation, and bone mineral density. This study aims to investigate whether serum levels of MOTS-c are altered in patients with preeclampsia.

Material and methods: This is cross sectional a case-control study of 30 patients with uncomplicated pregnancy, 30 patients with mild preeclampsia and 30 patients with severe preeclampsia that were admitted to the study center between June 2020 and January 2021.

Results: When compared to the healthy controls and patients with mild preeclampsia, maternal smoking was significantly more frequent, systolic and diastolic blood pressures were significantly higher and platelet count was significantly lower in patients with severe preeclampsia (p = 0.045, p = 0.0001, p = 0.0001 and p = 0.024 respectively). Serum MOTS-c concentrations were statistically similar in healthy controls, mild and severe preeclampsia patients (159.1 ± 28.7 ng/mL vs 129.6 ± 54.7 ng/mL vs 146.4 ± 48.3, p = 0.166). When compared to the healthy controls, systolic and diastolic blood pressures were significantly higher and platelet count was significantly lower in patients with late onset preeclampsia (p = 0.0001, p = 0.0001 and p = 0.022 respectively). Healthy controls and patients with early and late onset preeclampsia were statistically similar with respect to MOTS-c levels (159.1 ± 28.7 ng/mL vs 126.7 ± 56.9 vs 153.7 ± 39.8, p = 0.102).

Conclusions: This study failed to detect any significant relationship between MOTS-c and preeclampsia. Large scale research is needed to clarify if MOTS-c is a novel biomarker for preeclampsia and therapeutic target for preeclampsia patients.

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Keywords

endothelium; mitochondria; preeclampsia

About this article
Title

Serum MOTS-c levels remain unchanged in patients with preeclampsia

Journal

Ginekologia Polska

Issue

Vol 94, No 8 (2023)

Article type

Research paper

Pages

633-637

Published online

2022-10-07

Page views

595

Article views/downloads

272

DOI

10.5603/GP.a2022.0095

Bibliographic record

Ginekol Pol 2023;94(8):633-637.

Keywords

endothelium
mitochondria
preeclampsia

Authors

Abdullah Tok
Ozer Serdar
Omer Faruk Kandilcik
Filiz Alkan-Baylan

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