open access

Vol 93, No 10 (2022)
Research paper
Published online: 2022-10-05
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Reproductive outcomes of IVF after comprehensive endometriosis treatment: a prospective cohort study

Jovan Bila12, Snezana Vidakovic12, Svetlana Spremovic Radjenovic12, Jelena Dotlic12, Lidija Tulic12, Jelena Stojnic12, Jelena Micic12, Andrea Tinelli34
·
Pubmed: 36748176
·
Ginekol Pol 2022;93(10):827-834.
Affiliations
  1. Clinic of Obstetrics and Gynecology University Clinical Center of Serbia, Belgrade, Serbia
  2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  3. Department of Obstetrics and Gynecology, “Veris delli Ponti” Hospital, Scorrano, Lecce, Italy
  4. Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Vito Fazzi Hospital, Lecce, Italy

open access

Vol 93, No 10 (2022)
ORIGINAL PAPERS Obstetrics
Published online: 2022-10-05

Abstract

Objectives: To evaluate the impact of pharmacological and surgical endometriosis treatment on IVF reproductive outcomes in patients with primary infertility.
Material and methods: The study, conducted over a five year period, included 73 patients with endometriosis associated primary infertility subjected to 77 cycles. Group I included patients treated for endometriosis before the IVF (subgroups A: surgical and pharmacological treatment and B: only surgical treatment). Group II included patients immediately subjected to IVF. Assessed outcomes were pregnancy rate (PR) per started cycle, fertilization rate (FR), implantation rate (IR) and live birth rate (LBR).
Results: Group IA included 25 patients, Group IB 21 and Group II 27 patients. FR and IR showed no significant differences between groups. PR was significantly higher in the Group I than Group II (49% vs 25%, p = 0.030). PR per started cycle was the highest in the Group IA and the lowest in the Group II (p = 0.040). LBR was significantly higher in whole Group I (p = 0.043) and subgroup IA (p = 0.020) than Group II. Group IA and IB did not differ regarding examined outcomes. Regression analysis showed that endometriosis pretreatment method can impact both achieving pregnancy (p = 0.036) and having a live born child (p = 0.008) after IVF. The combined surgical and pharmacological endometriosis treatment, shorter infertility duration, lower EFI score, using long protocol with FSH+HMG gonadotropins increase the probability of successful IVF.
Conclusions: A combined surgical and pharmacological endometriosis treatment had a positive impact on IVF reproductive outcomes, both on pregnancy and on live birth rates.

Abstract

Objectives: To evaluate the impact of pharmacological and surgical endometriosis treatment on IVF reproductive outcomes in patients with primary infertility.
Material and methods: The study, conducted over a five year period, included 73 patients with endometriosis associated primary infertility subjected to 77 cycles. Group I included patients treated for endometriosis before the IVF (subgroups A: surgical and pharmacological treatment and B: only surgical treatment). Group II included patients immediately subjected to IVF. Assessed outcomes were pregnancy rate (PR) per started cycle, fertilization rate (FR), implantation rate (IR) and live birth rate (LBR).
Results: Group IA included 25 patients, Group IB 21 and Group II 27 patients. FR and IR showed no significant differences between groups. PR was significantly higher in the Group I than Group II (49% vs 25%, p = 0.030). PR per started cycle was the highest in the Group IA and the lowest in the Group II (p = 0.040). LBR was significantly higher in whole Group I (p = 0.043) and subgroup IA (p = 0.020) than Group II. Group IA and IB did not differ regarding examined outcomes. Regression analysis showed that endometriosis pretreatment method can impact both achieving pregnancy (p = 0.036) and having a live born child (p = 0.008) after IVF. The combined surgical and pharmacological endometriosis treatment, shorter infertility duration, lower EFI score, using long protocol with FSH+HMG gonadotropins increase the probability of successful IVF.
Conclusions: A combined surgical and pharmacological endometriosis treatment had a positive impact on IVF reproductive outcomes, both on pregnancy and on live birth rates.

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Keywords

endometriosis; infertility; IVF; minimally invasive surgery; reproductive outcome

About this article
Title

Reproductive outcomes of IVF after comprehensive endometriosis treatment: a prospective cohort study

Journal

Ginekologia Polska

Issue

Vol 93, No 10 (2022)

Article type

Research paper

Pages

827-834

Published online

2022-10-05

Page views

3917

Article views/downloads

672

DOI

10.5603/GP.a2022.0093

Pubmed

36748176

Bibliographic record

Ginekol Pol 2022;93(10):827-834.

Keywords

endometriosis
infertility
IVF
minimally invasive surgery
reproductive outcome

Authors

Jovan Bila
Snezana Vidakovic
Svetlana Spremovic Radjenovic
Jelena Dotlic
Lidija Tulic
Jelena Stojnic
Jelena Micic
Andrea Tinelli

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