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Does asymptomatic/uncomplicated SARS-CoV-2 infection during pregnancy increase the risk of spontaneous preterm birth?
, 2, 1, 1, 1, 3, 1, 2
Affiliations- Department of Obstetrics and Gynecology, University of Health Sciences, Zeynep Kamil Women and Children’s Disease Training and Research Hospital, Zeynep Kamil, Dr. Burhanettin Üstünel Sokağı, Üsküdar/İstanbul, Türkiye
- Department of Public Health, Marmara University Faculty of Medicine, Istanbul, Türkiye
- Division on Nursing, University of Health Sciences, Zeynep Kamil Women and Childrens Diesease Training and Research Hospital, Department of Obstetrics and Gynecology, İstanbul, Türkiye
open access
Abstract
Objectives: The aim of this study was to analyze the perinatal outcomes of asymptomatic/uncomplicated SARS-CoV-2 infection during pregnancy and the relationship between gestational age at the time of infection and spontaneous preterm birth (PTB). Material and methods: This was a retrospective cohort study. The study population included pregnant women who were 19–45 years old and who had been admitted to a Research and Training Hospital for singleton birth delivery. Women who had contracted SARS-CoV-2 during their pregnancy (n = 102) were compared to those who were not infected (n = 378) for the development of spontaneous PTB and other perinatal outcomes. The factors associated with spontaneous PTB were analyzed through univariate and multivariate methods. Results: Spontaneous PTB developed in 22.5% of the pregnant women with a history of SARS-CoV-2 infection and in 5.3% without a history of the infection (p < 0.001). The multivariate model determined that compared to the non-infected women, the OR of spontaneous PTB among those who had contracted the virus in the first, second, and the third trimesters were 9.13 (p < 0.001), 1.85 (p = 0.292) and 7.09 (p < 0.001), respectively. Pregnancy cholestasis (3.9% vs 0.5%; p = 0.020) and placental abruption (3.9% vs 0.5%; p = 0.040) were significantly higher in cases with a history of SARS-CoV-2 infection compared to the non-infected women. Conclusions: Asymptomatic or uncomplicated SARS-CoV-2 infection during pregnancy increases the risk of spontaneous PTB. This risk is higher particularly among pregnant women who develop the infection in the first and the third trimesters.
Abstract
Objectives: The aim of this study was to analyze the perinatal outcomes of asymptomatic/uncomplicated SARS-CoV-2 infection during pregnancy and the relationship between gestational age at the time of infection and spontaneous preterm birth (PTB). Material and methods: This was a retrospective cohort study. The study population included pregnant women who were 19–45 years old and who had been admitted to a Research and Training Hospital for singleton birth delivery. Women who had contracted SARS-CoV-2 during their pregnancy (n = 102) were compared to those who were not infected (n = 378) for the development of spontaneous PTB and other perinatal outcomes. The factors associated with spontaneous PTB were analyzed through univariate and multivariate methods. Results: Spontaneous PTB developed in 22.5% of the pregnant women with a history of SARS-CoV-2 infection and in 5.3% without a history of the infection (p < 0.001). The multivariate model determined that compared to the non-infected women, the OR of spontaneous PTB among those who had contracted the virus in the first, second, and the third trimesters were 9.13 (p < 0.001), 1.85 (p = 0.292) and 7.09 (p < 0.001), respectively. Pregnancy cholestasis (3.9% vs 0.5%; p = 0.020) and placental abruption (3.9% vs 0.5%; p = 0.040) were significantly higher in cases with a history of SARS-CoV-2 infection compared to the non-infected women. Conclusions: Asymptomatic or uncomplicated SARS-CoV-2 infection during pregnancy increases the risk of spontaneous PTB. This risk is higher particularly among pregnant women who develop the infection in the first and the third trimesters.
Keywords
SARS-CoV-2; COVID-19 pandemic; pregnancy; preterm birth; perinatal outcome
About this articleTitle
Does asymptomatic/uncomplicated SARS-CoV-2 infection during pregnancy increase the risk of spontaneous preterm birth?
Journal
Issue
Article type
Research paper
Pages
704-713
Published online
2022-09-21
Page views
494
Article views/downloads
418
DOI
Pubmed
Bibliographic record
Ginekol Pol 2023;94(9):704-713.
Keywords
SARS-CoV-2
COVID-19 pandemic
pregnancy
preterm birth
perinatal outcome
Authors
Pınar Kumru
Seyhan Hidiroglu
Ebru Cogendez
Habibe Ayvaci
Betül Yilmazer
Hümeyra Erol
Oya Demirci
Pınar Ay
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