open access

Vol 94, No 5 (2023)
Research paper
Published online: 2022-08-23
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GnRH agonist administration as luteal support on the transfer day of single blastocyst in dual-triggered cycles

Ahmet Demir1, Can Köse1, Ebru Şahin Güleç1, Pınar Türkmen1, Emrah Töz1, Nuri Peker2
·
Pubmed: 35997216
·
Ginekol Pol 2023;94(5):374-388.
Affiliations
  1. Tepecik Training and Research Hospital Izmir, Turkey
  2. Medicalpark Elazığ Hospital, Turkey

open access

Vol 94, No 5 (2023)
ORIGINAL PAPERS Obstetrics
Published online: 2022-08-23

Abstract

Objectives: Luteal phase support with gonadotropin-releasing hormone agonist (GnRH-a) has been considered in terms of its potential beneficial effects on in vitro fertilisation (IVF) cycles. In our study, we assessed the effectiveness of single-dose GnRH-a administration in dual-triggered cycles on pregnancy outcomes.
Material and methods: Eighty women who underwent intra cytoplasmic sperm injection (ICSI) cycle and had fresh blastocyst transfer were divided into two groups in terms of luteal phase support. The study group (Group A) consisted of patients (n = 40) who received a single-dose GnRH-a injection (0.1 mg of triptorelin acetate) subcutaneously 6 days after oocyte retrieval in addition to 600 mg daily of micronised progesterone, and the control group (Group B) comprised of patients (n = 40) taking 600 mg micronised progesterone daily from the first day after oocyte retrieval. GnRH-a and human chorionic gonadotropin (hCG; dual trigger) were administered to all patients. Comparison of the clinical pregnancy and live birth rates was our main goal.
Results: There was no significant difference between the two groups in terms of β-hCG positivity rates, clinical pregnancy rates and live birth rates (p value for beta-hCG = 0.25, clinical pregnancy = 0.80, live birth = 0.45).
Conclusions: Our study demonstrated that in dual triggered cycles administration of a single dose of GnRH-a on the transfer day of a single blastocyst in addition to routine luteal phase support with progesterone does not statistically increase implantation, clinical pregnancy or live birth rates.

Abstract

Objectives: Luteal phase support with gonadotropin-releasing hormone agonist (GnRH-a) has been considered in terms of its potential beneficial effects on in vitro fertilisation (IVF) cycles. In our study, we assessed the effectiveness of single-dose GnRH-a administration in dual-triggered cycles on pregnancy outcomes.
Material and methods: Eighty women who underwent intra cytoplasmic sperm injection (ICSI) cycle and had fresh blastocyst transfer were divided into two groups in terms of luteal phase support. The study group (Group A) consisted of patients (n = 40) who received a single-dose GnRH-a injection (0.1 mg of triptorelin acetate) subcutaneously 6 days after oocyte retrieval in addition to 600 mg daily of micronised progesterone, and the control group (Group B) comprised of patients (n = 40) taking 600 mg micronised progesterone daily from the first day after oocyte retrieval. GnRH-a and human chorionic gonadotropin (hCG; dual trigger) were administered to all patients. Comparison of the clinical pregnancy and live birth rates was our main goal.
Results: There was no significant difference between the two groups in terms of β-hCG positivity rates, clinical pregnancy rates and live birth rates (p value for beta-hCG = 0.25, clinical pregnancy = 0.80, live birth = 0.45).
Conclusions: Our study demonstrated that in dual triggered cycles administration of a single dose of GnRH-a on the transfer day of a single blastocyst in addition to routine luteal phase support with progesterone does not statistically increase implantation, clinical pregnancy or live birth rates.

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Keywords

GnRH agonist; luteal phase support; IVF

About this article
Title

GnRH agonist administration as luteal support on the transfer day of single blastocyst in dual-triggered cycles

Journal

Ginekologia Polska

Issue

Vol 94, No 5 (2023)

Article type

Research paper

Pages

374-388

Published online

2022-08-23

Page views

2008

Article views/downloads

487

DOI

10.5603/GP.a2022.0082

Pubmed

35997216

Bibliographic record

Ginekol Pol 2023;94(5):374-388.

Keywords

GnRH agonist
luteal phase support
IVF

Authors

Ahmet Demir
Can Köse
Ebru Şahin Güleç
Pınar Türkmen
Emrah Töz
Nuri Peker

References (16)
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