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Vol 93, No 8 (2022)
Research paper
Published online: 2022-06-28
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Risk factors associated with neonatal infectious and respiratory morbidity following preterm premature rupture of membranes

Joanna Kacperczyk-Bartnik1, Pawel Bartnik1, Justyna Teliga-Czajkowska2, Aneta Malinowska-Polubiec1, Agnieszka Dobrowolska-Redo1, Ewa Romejko-Wolniewicz1, Janusz Sierdzinski3, Ksawery Golawski4, Krzysztof Czajkowski1
DOI: 10.5603/GP.a2022.0066
·
Ginekol Pol 2022;93(8):629-636.
Affiliations
  1. 2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland
  2. Department of Obstetrics and Gynecology Didactics, Medical University of Warsaw, Poland
  3. Department of Medical Informatics and Telemedicine, Medical University of Warsaw, Poland
  4. Students’ Scientific Group affiliated to 2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland

open access

Vol 93, No 8 (2022)
ORIGINAL PAPERS Obstetrics
Published online: 2022-06-28

Abstract

Objectives: Preterm premature rupture of membranes (pPROM) is associated with the increased risk of chorioamnionitis, foetal exposure to inflammation, and respiratory complications in preterm neonates. The aim of the study was to identify patients at highest risk of developing neonatal infectious and respiratory morbidity following pPROM and preterm birth.

Material and methods: It was a retrospective cohort study including 299 consecutive patients in singleton pregnancies complicated by preterm premature rupture of membranes and giving birth between 22nd and 36th gestational week. Analysed factors included maternal characteristics, obstetric history, gestational age at pPROM and at delivery, latency and management. Multivariate logistic regression models were applied in order to identify risk factors for severe infectious and respiratory neonatal complications.

Results: Earlier gestational age at pPROM is associated with increased probability of developing early-onset neonatal sepsis and pulmonary hypertension. Earlier gestational age at birth and lower birth weight were independent factors associated with neonatal respiratory distress syndrome. Positive cervical culture was identified as a risk factor for acute neonatal respiratory failure.

Conclusions: Gestational age at pPROM, gestational age at birth and birth weight were the leading factors influencing the risk of developing neonatal infectious and respiratory morbidity following preterm premature rupture of membranes.

Abstract

Objectives: Preterm premature rupture of membranes (pPROM) is associated with the increased risk of chorioamnionitis, foetal exposure to inflammation, and respiratory complications in preterm neonates. The aim of the study was to identify patients at highest risk of developing neonatal infectious and respiratory morbidity following pPROM and preterm birth.

Material and methods: It was a retrospective cohort study including 299 consecutive patients in singleton pregnancies complicated by preterm premature rupture of membranes and giving birth between 22nd and 36th gestational week. Analysed factors included maternal characteristics, obstetric history, gestational age at pPROM and at delivery, latency and management. Multivariate logistic regression models were applied in order to identify risk factors for severe infectious and respiratory neonatal complications.

Results: Earlier gestational age at pPROM is associated with increased probability of developing early-onset neonatal sepsis and pulmonary hypertension. Earlier gestational age at birth and lower birth weight were independent factors associated with neonatal respiratory distress syndrome. Positive cervical culture was identified as a risk factor for acute neonatal respiratory failure.

Conclusions: Gestational age at pPROM, gestational age at birth and birth weight were the leading factors influencing the risk of developing neonatal infectious and respiratory morbidity following preterm premature rupture of membranes.

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Keywords

bronchopulmonary dysplasia; neonatal sepsis; pprom; premature birth; respiratory distress syndrome; respiratory insufficiency; transient tachypnea of the newborn

About this article
Title

Risk factors associated with neonatal infectious and respiratory morbidity following preterm premature rupture of membranes

Journal

Ginekologia Polska

Issue

Vol 93, No 8 (2022)

Article type

Research paper

Pages

629-636

Published online

2022-06-28

Page views

4092

Article views/downloads

431

DOI

10.5603/GP.a2022.0066

Bibliographic record

Ginekol Pol 2022;93(8):629-636.

Keywords

bronchopulmonary dysplasia
neonatal sepsis
pprom
premature birth
respiratory distress syndrome
respiratory insufficiency
transient tachypnea of the newborn

Authors

Joanna Kacperczyk-Bartnik
Pawel Bartnik
Justyna Teliga-Czajkowska
Aneta Malinowska-Polubiec
Agnieszka Dobrowolska-Redo
Ewa Romejko-Wolniewicz
Janusz Sierdzinski
Ksawery Golawski
Krzysztof Czajkowski

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