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Relationship of cystatin C, Hs-CRP, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with isolated oligohydramnios
, 2
Affiliations- Kutahya Health Sciences University, Kutahya, Turkey
- Amasya University, School of Medicine, Amasya, Turkey
open access
Abstract
Objectives: We evaluated inflammatory parameters in pregnant women with isolated oligohydramnios.
Material and methods: This prospective cross-sectional study enrolled 54 pregnant with isolated oligohydramnios (IO) and 54 matched by gestational week, healthy pregnant with normal amniotic fluid. Maternal plasma levels of cystatin C, hs-CRP, neutrophil-lymphocyte ratios (NLR), platelet-lymphocyte ratios (PLR), and pregnancy outcomes were compared between two groups.
Results: Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than that in the control group (p < 0.05). In the IO group, the rate of primary cesarean section, fetal distress, neonates with meconium-stained, and need for neonatal intensive care unit was higher, and Apgar scores were significantly lower than those in the control group (p < 0.05). There was no significant difference between the groups for meconium-stained neonate rates and the intensive care unit’s need in the late-term (410/7–416/7 weeks). Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than the control group (p < 0.05). Cystatin C was positively correlated with the need for neonatal intensive care and negatively correlated with Apgar scores. The PLR was positively correlated with the rate of meconium-stained neonates (p < 0.05). Cystatin C and hs-CRP had significant value in predicting IO (p < 0.05).
Conclusions: Maternal serum levels of Cystatin C and hs-CRP may support the diagnosis and prediction of perinatal
outcomes as possible biochemical markers in IO cases. In particular, a high level of cystatin C may indicate the need
for neonatal intensive care and low Apgar scores. In addition, late-term IO may show similar results in meconium
and neonatal intensive care needs compared to without oligohydramnios.
Abstract
Objectives: We evaluated inflammatory parameters in pregnant women with isolated oligohydramnios.
Material and methods: This prospective cross-sectional study enrolled 54 pregnant with isolated oligohydramnios (IO) and 54 matched by gestational week, healthy pregnant with normal amniotic fluid. Maternal plasma levels of cystatin C, hs-CRP, neutrophil-lymphocyte ratios (NLR), platelet-lymphocyte ratios (PLR), and pregnancy outcomes were compared between two groups.
Results: Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than that in the control group (p < 0.05). In the IO group, the rate of primary cesarean section, fetal distress, neonates with meconium-stained, and need for neonatal intensive care unit was higher, and Apgar scores were significantly lower than those in the control group (p < 0.05). There was no significant difference between the groups for meconium-stained neonate rates and the intensive care unit’s need in the late-term (410/7–416/7 weeks). Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than the control group (p < 0.05). Cystatin C was positively correlated with the need for neonatal intensive care and negatively correlated with Apgar scores. The PLR was positively correlated with the rate of meconium-stained neonates (p < 0.05). Cystatin C and hs-CRP had significant value in predicting IO (p < 0.05).
Conclusions: Maternal serum levels of Cystatin C and hs-CRP may support the diagnosis and prediction of perinatal
outcomes as possible biochemical markers in IO cases. In particular, a high level of cystatin C may indicate the need
for neonatal intensive care and low Apgar scores. In addition, late-term IO may show similar results in meconium
and neonatal intensive care needs compared to without oligohydramnios.
Keywords
cystatin C; Hs-CRP; neutrophil-lymphocyte ratio; oligohydramnios; platelet-lymphocyte ratio
About this articleTitle
Relationship of cystatin C, Hs-CRP, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with isolated oligohydramnios
Journal
Issue
Article type
Research paper
Pages
881-888
Published online
2022-02-10
Page views
3999
Article views/downloads
513
DOI
Pubmed
Bibliographic record
Ginekol Pol 2022;93(11):881-888.
Keywords
cystatin C
Hs-CRP
neutrophil-lymphocyte ratio
oligohydramnios
platelet-lymphocyte ratio
Authors
Ozlem Erten
Aysun Tekeli Taskomur
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