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Vol 93, No 2 (2022)
Research paper
Published online: 2021-12-15
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Impact of advanced maternal age on maternal and neonatal outcomes in preterm birth

Lin Lu1, Jian-Hua Li1, Xiao-Feng Dai1, Juan-Bing Wei1, Li-Hong Chen1, Ji-Fen Hu1
DOI: 10.5603/GP.a2021.0224
·
Pubmed: 35072250
·
Ginekol Pol 2022;93(2):134-141.
Affiliations
  1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

open access

Vol 93, No 2 (2022)
ORIGINAL PAPERS Obstetrics
Published online: 2021-12-15

Abstract

Objectives: The aim of this study was to investigate the influence of advanced maternal age on the maternal and neonatal outcomes of preterm pregnancies.

Material and methods: The characteristics of patients admitted to the Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University between January 2015 and March, 2019 were retrospectively reviewed. The maternal and neonatal outcomes were compared between advanced maternal age group (≥ 35 years) and younger age group (18–34 years). Statistical analysis was performed by applying the SPSS software.

Results: The study population consisted of 986 pregnancies with preterm delivery and 1094 liveborn preterm infants. Multivariate analyses demonstrated that mothers of advanced age were more likely to suffer iatrogenic preterm birth, placenta previa, preeclampsia, gestational diabetes mellitus and postpartum hemorrhage, but less likely to suffer multiple gestation. In terms of neonatal outcomes, advanced maternal age was associated with a decreased rate of low birthweight in an adjusted model without multiple gestation. However, with multiple gestation included in the adjusted model, advanced maternal age was only associated with an increased rate of hyperbilirubinemia.

Conclusions: Advanced maternal age was a risk factor for adverse pregnancy outcomes including iatrogenic preterm birth, placenta previa, preeclampsia, gestational diabetes mellitus, postpartum hemorrhage, and a protective factor for multiple gestation. Regarding neonatal outcomes, advanced maternal age was related to a decreased rate of low birthweight or an increased rate of hyperbilirubinemia depending on the adjustment for multiple gestation.

Abstract

Objectives: The aim of this study was to investigate the influence of advanced maternal age on the maternal and neonatal outcomes of preterm pregnancies.

Material and methods: The characteristics of patients admitted to the Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University between January 2015 and March, 2019 were retrospectively reviewed. The maternal and neonatal outcomes were compared between advanced maternal age group (≥ 35 years) and younger age group (18–34 years). Statistical analysis was performed by applying the SPSS software.

Results: The study population consisted of 986 pregnancies with preterm delivery and 1094 liveborn preterm infants. Multivariate analyses demonstrated that mothers of advanced age were more likely to suffer iatrogenic preterm birth, placenta previa, preeclampsia, gestational diabetes mellitus and postpartum hemorrhage, but less likely to suffer multiple gestation. In terms of neonatal outcomes, advanced maternal age was associated with a decreased rate of low birthweight in an adjusted model without multiple gestation. However, with multiple gestation included in the adjusted model, advanced maternal age was only associated with an increased rate of hyperbilirubinemia.

Conclusions: Advanced maternal age was a risk factor for adverse pregnancy outcomes including iatrogenic preterm birth, placenta previa, preeclampsia, gestational diabetes mellitus, postpartum hemorrhage, and a protective factor for multiple gestation. Regarding neonatal outcomes, advanced maternal age was related to a decreased rate of low birthweight or an increased rate of hyperbilirubinemia depending on the adjustment for multiple gestation.

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Keywords

advanced maternal age; multiple gestation; preterm birth; pregnancy outcome; preeclampsia

About this article
Title

Impact of advanced maternal age on maternal and neonatal outcomes in preterm birth

Journal

Ginekologia Polska

Issue

Vol 93, No 2 (2022)

Article type

Research paper

Pages

134-141

Published online

2021-12-15

Page views

6198

Article views/downloads

1445

DOI

10.5603/GP.a2021.0224

Pubmed

35072250

Bibliographic record

Ginekol Pol 2022;93(2):134-141.

Keywords

advanced maternal age
multiple gestation
preterm birth
pregnancy outcome
preeclampsia

Authors

Lin Lu
Jian-Hua Li
Xiao-Feng Dai
Juan-Bing Wei
Li-Hong Chen
Ji-Fen Hu

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