open access

Vol 93, No 6 (2022)
Research paper
Published online: 2022-01-29
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Evaluation of the effectiveness of Ampicillin and Lactobacillus casei rhamnosus treatment in cases of preterm premature rupture of membranes remote from term

Salih Burcin Kavak1, Ebru Celik Kavak1, Ahmet Senocak1, Mesut Ali Haliscelik1, Bunyamin Cim1, Ekrem Sapmaz2
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Pubmed: 35106748
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Ginekol Pol 2022;93(6):482-488.
Affiliations
  1. Firat University, School of Medicine, Department of Obstetrics and Gynecology, Elazig, Turkey
  2. Adana Numune Training and Research Hospital, Department of Obstetrics and Gynecology, Adana, Turkey

open access

Vol 93, No 6 (2022)
ORIGINAL PAPERS Obstetrics
Published online: 2022-01-29

Abstract

Objectives: Preterm premature rupture of membranes (PPROM) remote from term is an important obstetric cause of maternal and fetal adverse outcomes. The aim of our study is to examine the efficacy of ampicillin and Lactobacillus casei rhamnosus treatment in cases of PPROM remote from term. Material and methods: The study was carried out by examining the results of cases who were given Ampicillin and Lactobacillus casei rhamnosus treatment. The patients were divided into two groups. Group 1 who didn’t develop clinical chorioamnionitis and Group 2 who developed clinical chorioamnionitis. Obstetric characteristics, neonatal outcomes, adverse events were recorded. Results: A total of 46 pregnant women, 40 in Group 1 and six in Group 2, were included in the study. The frequency of clinical chorioamnionitis developing during the treatment was found to be 13.0%. Mean gestational age at diagnosis was 28.43 ± 2.38 and 28.17 ± 1.33 for Groups 1 and Group 2, respectively. Mean gestational age at the time of delivery was 32.38 ± 2.07 31.33 ± 1.63 for Group 1 and Group 2, respectively. The mean latency period for Group 1 and Group 2 was 27.45 ± 1.71 days, 23.66 ± 4.53, respectively. Sepsis developed in six newborns (15%) in Group 1, while it developed in three newborns (50%) in Group 2. While 90% of the babies in Group 1 were discharged from the hospital, this rate was 66.7% in Group 2. Conclusions: Ampicillin + Lactobacillus casei rhamnosus is an effective treatment method in PPROM cases and positively affects perinatal outcomes.

Abstract

Objectives: Preterm premature rupture of membranes (PPROM) remote from term is an important obstetric cause of maternal and fetal adverse outcomes. The aim of our study is to examine the efficacy of ampicillin and Lactobacillus casei rhamnosus treatment in cases of PPROM remote from term. Material and methods: The study was carried out by examining the results of cases who were given Ampicillin and Lactobacillus casei rhamnosus treatment. The patients were divided into two groups. Group 1 who didn’t develop clinical chorioamnionitis and Group 2 who developed clinical chorioamnionitis. Obstetric characteristics, neonatal outcomes, adverse events were recorded. Results: A total of 46 pregnant women, 40 in Group 1 and six in Group 2, were included in the study. The frequency of clinical chorioamnionitis developing during the treatment was found to be 13.0%. Mean gestational age at diagnosis was 28.43 ± 2.38 and 28.17 ± 1.33 for Groups 1 and Group 2, respectively. Mean gestational age at the time of delivery was 32.38 ± 2.07 31.33 ± 1.63 for Group 1 and Group 2, respectively. The mean latency period for Group 1 and Group 2 was 27.45 ± 1.71 days, 23.66 ± 4.53, respectively. Sepsis developed in six newborns (15%) in Group 1, while it developed in three newborns (50%) in Group 2. While 90% of the babies in Group 1 were discharged from the hospital, this rate was 66.7% in Group 2. Conclusions: Ampicillin + Lactobacillus casei rhamnosus is an effective treatment method in PPROM cases and positively affects perinatal outcomes.

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Keywords

preterm premature rupture of membranes; ampicillin; L. casei rhamnosus; clinical chorioamnionitis

About this article
Title

Evaluation of the effectiveness of Ampicillin and Lactobacillus casei rhamnosus treatment in cases of preterm premature rupture of membranes remote from term

Journal

Ginekologia Polska

Issue

Vol 93, No 6 (2022)

Article type

Research paper

Pages

482-488

Published online

2022-01-29

Page views

4784

Article views/downloads

726

DOI

10.5603/GP.a2021.0212

Pubmed

35106748

Bibliographic record

Ginekol Pol 2022;93(6):482-488.

Keywords

preterm premature rupture of membranes
ampicillin
L. casei rhamnosus
clinical chorioamnionitis

Authors

Salih Burcin Kavak
Ebru Celik Kavak
Ahmet Senocak
Mesut Ali Haliscelik
Bunyamin Cim
Ekrem Sapmaz

References (37)
  1. Ugwumadu A. Chapter 20 - Preterm Prelabour Rupture of Membranes (pPROM). In: Sir Arulkumaran A. ed. Best Practice in Labour and Delivery 2nd edition. Cambridge University Press 2016: 242–249.
  2. Henriquez GG, Rodrigo FGM. Chorioamnionitis and neonatal morbidity: current perspectives. Res Rep Neonatol. 2017; Volume 7: 41–52.
  3. Mercer B. Preterm premature rupture of the membranes. Obstet Gynecol. 2003; 101(1): 178–193.
  4. Yoon BH, Romero R, Moon JB, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2001; 185(5): 1130–1136.
  5. Rouse DJ, Landon M, Leveno KJ, et al. The Maternal-Fetal Medicine Units cesarean registry: chorioamnionitis at term and its duration-relationship to outcomes. Am J Obstet Gynecol. 2004; 191(1): 211–216.
  6. Perry AK, Rossi RM, DeFranco EA. Severe adverse maternal outcomes associated with chorioamnionitis. Am J Obstet Gynecol MFM. 2019; 1(3): 100027.
  7. Venkatesh KK, Glover AV, Vladutiu CJ, et al. Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study. BJOG. 2019; 126(6): 719–727.
  8. Romero R, Mazor M. Infection and preterm labor. Clin Obstet Gynecol. 1988; 31(3): 553–584.
  9. Galaz J, Romero R, Slutsky R, et al. Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes. J Perinat Med. 2020; 48(3): 222–233.
  10. Romero R, Chaemsaithong P, Korzeniewski SJ, et al. Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response. J Perinat Med. 2016; 44(1): 5–22.
  11. Shalak LF, Laptook AR, Jafri HS, et al. Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants. Pediatrics. 2002; 110(4): 673–680.
  12. Arad I, Ergaz Z. The fetal inflammatory response syndrome and associated infant morbidity. Isr Med Assoc J. 2004; 6(12): 766–769.
  13. Kenyon S, Boulvain M, Neilson JP. Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev. 2013(12): CD001058.
  14. Oboro VO, Adekanle BA, Apantaku BD, et al. Pre-term pre-labour rupture of membranes: effect of chorioamnionitis on overall neonatal outcome. J Obstet Gynaecol. 2006; 26(8): 740–743.
  15. Blackwell SC, Berry SM. Role of amniocentesis for the diagnosis of subclinical intra-amniotic infection in preterm premature rupture of the membranes. Curr Opin Obstet Gynecol. 1999; 11(6): 541–547.
  16. Kyle P, Turner DP. Chorioamnionitis due to pseudomonas aeruginosa: a complication of prolonged antibiotic therapy for premature rupture of membranes. Br J Obstet Gynaecol. 1996; 103(2): 181–183.
  17. Othman M, Neilson JP, Alfirevic Z. Probiotics for preventing preterm labour. Cochrane Database Syst Rev. 2007(1).
  18. Kavak SB, Kavak E, Ilhan R, et al. The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term. Drug Des Devel Ther. 2014; 8: 1169–1173.
  19. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics. Practice Bulletin No. 171: Management of Preterm Labor. Obstet Gynecol. 2016; 128(4): e155–e164.
  20. Newton ER. Preterm labor, preterm premature rupture of membranes, and chorioamnionitis. Clin Perinatol. 2005; 32(3): 571–600.
  21. Yudin M, Schalkwyk Jv, Eyk N, et al. Antibiotic Therapy in Preterm Premature Rupture of the Membranes. J Obstet Gynaecol Can. 2009; 31(9): 863–867.
  22. Fox NS, Gelber SE, Kalish RB, et al. The recommendation for bed rest in the setting of arrested preterm labor and premature rupture of membranes. Am J Obstet Gynecol. 2009; 200(2): 165.e1–165.e6.
  23. Rouse DJ, Hirtz DG, Thom E, et al. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med. 2008; 359(9): 895–905.
  24. Newton ER. Chorioamnionitis and intraamniotic infection. Clin Obstet Gynecol. 1993; 36(4): 795–808.
  25. Botet F, Figueras J, Carbonell-Estrany X, et al. Effect of maternal clinical chorioamnionitis on neonatal morbidity in very-low birthweight infants: a case-control study. J Perinat Med. 2010; 38(3): 269–273.
  26. Nasef N, Shabaan AE, Schurr P, et al. Effect of clinical and histological chorioamnionitis on the outcome of preterm infants. Am J Perinatol. 2013; 30(1): 59–68.
  27. Shim SS, Romero R, Hong JS, et al. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 2004; 191(4): 1339–1345.
  28. Morales WJ. The effect of chorioamnionitis on the developmental outcome of preterm infants at one year. Obstet Gynecol. 1987; 70(2): 183–186.
  29. Conde-Agudelo A, Romero R, Jung EJ, et al. Management of clinical chorioamnionitis: an evidence-based approach. Am J Obstet Gynecol. 2020; 223(6): 848–869.
  30. Daskalakis GJ, Karambelas AK. Vaginal Probiotic Administration in the Management of Preterm Premature Rupture of Membranes. Fetal Diagn Ther. 2017; 42(2): 92–98.
  31. O'Hanlon DE, Moench TR, Cone RA. Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PLoS One. 2013; 8(11): e80074.
  32. Hawes SE, Hillier SL, Benedetti J, et al. Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections. J Infect Dis. 1996; 174(5): 1058–1063.
  33. Yeganegi M, Watson CS, Martins A, et al. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. Am J Obstet Gynecol. 2009; 200(5): 532.e1–532.e8.
  34. Dugoua JJ, Machado M, Zhu Xu, et al. Probiotic safety in pregnancy: a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp. J Obstet Gynaecol Can. 2009; 31(6): 542–552.
  35. Bendix JM, Hegaard HK, Bergholt T, et al. Expectant management of PPROM and major complications before planned delivery: a retrospective cohort study. J Obstet Gynaecol. 2015; 35(6): 570–577.
  36. Aziz N, Cheng YW, Caughey AB. Neonatal outcomes in the setting of preterm premature rupture of membranes complicated by chorioamnionitis. J Matern Fetal Neonatal Med. 2009; 22(9): 780–784.
  37. Louis JM, Ehrenberg HM, Collin MF, et al. Perinatal intervention and neonatal outcomes near the limit of viability. Am J Obstet Gynecol. 2004; 191(4): 1398–1402.

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