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Research paper
Published online: 2021-11-05
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Expression and diagnostic value of serum protein Z and protein Z-dependent protease inhibitor in fetal growth restriction

Ci Pan1, Yulian Huang2, Xiaopei Guo2, Cunhua Gu2, Jing Guo2, Xiaohua Luo23
DOI: 10.5603/GP.a2021.0205
Affiliations
  1. Prenatal Diagnosis Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  2. Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  3. Henan provincial Clinical Research Center for Perinatal Medicine,The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

open access

Ahead of Print
ORIGINAL PAPERS Obstetrics
Published online: 2021-11-05

Abstract

Objectives: Investigating the expression levels of serum protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in fetal growth restriction (FGR) and to explore their diagnostic value in FGR.

Material and methods: In this study, the number of pregnant women with FGR, healthy pregnant women (Healthy Control, HC), and childbearing-age women without pregnancy (Blank Control, BC) is 79, 79, and 60, respectively; their serum PZ and ZPI levels in each group are determined by ELISAs. Then, the correlations between these indices and FGR were assessed using Spearman analysis. Moreover, these indices’ diagnostic values for FGR are evaluated using the receiver operating characteristics (ROC) curves.

Results: The serum levels of PZ and ZPI are significantly decreased in the HC and FGR groups compared against the BC group (P < 0.001), whilst the levels of PZ and ZPI in the FGR groups are lower than those in the HC group (P < 0.01) notably. PZ serum concentration has positive relationship with ZPI concentrations in the HC and FGR groups. The combination of PZ and ZPI, with the Area under the Curve (AUC) 0.92 (95% CI = 0.88–0.96), the sensitivity 0.82, and the specificity 0.88, outperforms everyone.

Conclusions: Serum PZ and ZPI are significantly decreased in pregnant women with FGR, which can be used for pregnant women’s FGR screening.

Abstract

Objectives: Investigating the expression levels of serum protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in fetal growth restriction (FGR) and to explore their diagnostic value in FGR.

Material and methods: In this study, the number of pregnant women with FGR, healthy pregnant women (Healthy Control, HC), and childbearing-age women without pregnancy (Blank Control, BC) is 79, 79, and 60, respectively; their serum PZ and ZPI levels in each group are determined by ELISAs. Then, the correlations between these indices and FGR were assessed using Spearman analysis. Moreover, these indices’ diagnostic values for FGR are evaluated using the receiver operating characteristics (ROC) curves.

Results: The serum levels of PZ and ZPI are significantly decreased in the HC and FGR groups compared against the BC group (P < 0.001), whilst the levels of PZ and ZPI in the FGR groups are lower than those in the HC group (P < 0.01) notably. PZ serum concentration has positive relationship with ZPI concentrations in the HC and FGR groups. The combination of PZ and ZPI, with the Area under the Curve (AUC) 0.92 (95% CI = 0.88–0.96), the sensitivity 0.82, and the specificity 0.88, outperforms everyone.

Conclusions: Serum PZ and ZPI are significantly decreased in pregnant women with FGR, which can be used for pregnant women’s FGR screening.

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Keywords

fetal growth restriction; protein Z; protein Z-dependent protease inhibitor; coagulation dysfunction; diagnosis

About this article
Title

Expression and diagnostic value of serum protein Z and protein Z-dependent protease inhibitor in fetal growth restriction

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-11-05

DOI

10.5603/GP.a2021.0205

Keywords

fetal growth restriction
protein Z
protein Z-dependent protease inhibitor
coagulation dysfunction
diagnosis

Authors

Ci Pan
Yulian Huang
Xiaopei Guo
Cunhua Gu
Jing Guo
Xiaohua Luo

References (24)
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