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Hyperthyroidism secondary to a hydatidiform mole
, 1, 1, 2, 1, 1
Affiliations- 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland
- Endocrine Oncology and Nuclear Medicine Clinic, M. Skłodowska-Curie Memorial Institute — Cancer Centre, Warsaw, Poland, Warsaw, Poland
open access
Abstract
The case presented in the article is that of a 47-year-old female patient with hyperthyroidism induced by a hydatidiform mole. Attention was drawn to the necessity of preparing the patient for a procedure with drugs that stabilize the hormonal activity of the thyroid. The removal of the hydatidiform mole resulted in gradual normalization of thyroid hormone levels.
The trophoblast has a hormonal activity, secrete hCG (human chorionic gonadotropin).The hCG partial structural homology causes affinity to the TSH (thyroid stimulating hormone) receptor. The higher the weight of the trophoblast, the higher the production and concentration of hCG in the blood.
Therefore, gestational trophoblastic disease may be accompanied by hyperthyroidism. The problem is frequently described, however, due to the risk of developing thyroid storm, it cannot be overlooked [1].
Abstract
The case presented in the article is that of a 47-year-old female patient with hyperthyroidism induced by a hydatidiform mole. Attention was drawn to the necessity of preparing the patient for a procedure with drugs that stabilize the hormonal activity of the thyroid. The removal of the hydatidiform mole resulted in gradual normalization of thyroid hormone levels.
The trophoblast has a hormonal activity, secrete hCG (human chorionic gonadotropin).The hCG partial structural homology causes affinity to the TSH (thyroid stimulating hormone) receptor. The higher the weight of the trophoblast, the higher the production and concentration of hCG in the blood.
Therefore, gestational trophoblastic disease may be accompanied by hyperthyroidism. The problem is frequently described, however, due to the risk of developing thyroid storm, it cannot be overlooked [1].
Keywords
gestational trophoblastic disease; hydatidiform mole; hCG; hyperthyroidism
About this articleTitle
Hyperthyroidism secondary to a hydatidiform mole
Journal
Issue
Article type
Clinical vignette
Pages
741-742
Published online
2021-09-27
Page views
6662
Article views/downloads
684
DOI
Pubmed
Bibliographic record
Ginekol Pol 2021;92(10):741-742.
Keywords
gestational trophoblastic disease
hydatidiform mole
hCG
hyperthyroidism
Authors
Barbara Grzechocinska
Malgorzata Gajewska
Maciej Kedzierski
Sylwia Gajda
Piotr Jedrzejak
Miroslaw Wielgos
References (4)- Moskovitz, J.B. and M.C. Bond, Molar pregnancy-induced thyroid storm. J Emerg Med, 2010. 38(5): p. : e71–6.
- Yoshimura M, Hershman JM. Thyrotropic action of human chorionic gonadotropin. Thyroid. 1995; 5(5): 425–434.
- Kofinas JD, Kruczek A, Sample J, et al. Thyroid storm-induced multi-organ failure in the setting of gestational trophoblastic disease. J Emerg Med. 2015; 48(1): 35–38.
- Samra T, Kaur R, Sharma N, et al. Peri-operative concerns in a patient with thyroid storm secondary to molar pregnancy. Indian J Anaesth. 2015; 59(11): 739–742.
