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Clinical vignette
Published online: 2021-09-27
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Hyperthyroidism secondary to a hydatidiform mole

Barbara Grzechocinska1, Malgorzata Gajewska1, Maciej Kedzierski1, Sylwia Gajda2, Piotr Jedrzejak1, Miroslaw Wielgos1
DOI: 10.5603/GP.a2021.0185
Affiliations
  1. 1st Chair and Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland
  2. Endocrine Oncology and Nuclear Medicine Clinic, M. Skłodowska-Curie Memorial Institute — Cancer Centre, Warsaw, Poland, Warsaw, Poland

open access

Ahead of Print
CLINICAL VIGNETTES
Published online: 2021-09-27

Abstract

The case presented in the article is that of a 47-year-old female patient with hyperthyroidism induced by a hydatidiform mole. Attention was drawn to the necessity of preparing the patient for a procedure with drugs that stabilize the hormonal activity of the thyroid. The removal of the hydatidiform mole resulted in gradual normalization of thyroid hormone levels.

The trophoblast has a hormonal activity, secrete hCG (human chorionic gonadotropin).The  hCG partial structural homology causes affinity to the TSH (thyroid stimulating hormone) receptor. The higher the weight of the trophoblast, the higher the production and concentration of hCG in the blood.

Therefore, gestational trophoblastic disease may be accompanied by hyperthyroidism. The problem is frequently described, however, due to the risk of developing thyroid storm, it cannot be overlooked [1].

.

Abstract

The case presented in the article is that of a 47-year-old female patient with hyperthyroidism induced by a hydatidiform mole. Attention was drawn to the necessity of preparing the patient for a procedure with drugs that stabilize the hormonal activity of the thyroid. The removal of the hydatidiform mole resulted in gradual normalization of thyroid hormone levels.

The trophoblast has a hormonal activity, secrete hCG (human chorionic gonadotropin).The  hCG partial structural homology causes affinity to the TSH (thyroid stimulating hormone) receptor. The higher the weight of the trophoblast, the higher the production and concentration of hCG in the blood.

Therefore, gestational trophoblastic disease may be accompanied by hyperthyroidism. The problem is frequently described, however, due to the risk of developing thyroid storm, it cannot be overlooked [1].

.

Get Citation

Keywords

gestational trophoblastic disease; hydatidiform mole; hCG, hyperthyroidism

About this article
Title

Hyperthyroidism secondary to a hydatidiform mole

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Clinical vignette

Published online

2021-09-27

DOI

10.5603/GP.a2021.0185

Keywords

gestational trophoblastic disease
hydatidiform mole
hCG
hyperthyroidism

Authors

Barbara Grzechocinska
Malgorzata Gajewska
Maciej Kedzierski
Sylwia Gajda
Piotr Jedrzejak
Miroslaw Wielgos

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