open access
Pregnancy combined with severe pneumonia caused by Chlamydia psittaci infection — a case report
Affiliations- Department of Emergency, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
open access
Abstract
Objective: Chlamydia psittaci (Cps) feeds on gram-negative aerobic cells. Respiratory inhalation of Cps or close contact with infected animals can cause psittacosis in humans. Given its challengeable early diagnosis and rapid progression, misdiagnosis or improper antibacterial drugs may lead to multi-organ dysfunction with a high mortality.
Case report: A pregnant woman at 29+1 weeks of gestational age had a fever. CT images of the chest showed lamellar consolidations in the inferior lobe of the right lung, light inflammation in the middle lobe of the right lung. Negative results were obtained from multiple times of blood and sputum culture. Next generation sequencing (NGS) results identified that Cps caused severe pneumonia, which was alleviated by specific antibiotic treatment.
Conclusion: Cps can cause severe pneumonia in the pregnant woman and be cured through precise antibiotic treatment. NGS is efficient in the rapid identification of pathogens and accurate diagnosis when bacteriological culture fails.
Abstract
Objective: Chlamydia psittaci (Cps) feeds on gram-negative aerobic cells. Respiratory inhalation of Cps or close contact with infected animals can cause psittacosis in humans. Given its challengeable early diagnosis and rapid progression, misdiagnosis or improper antibacterial drugs may lead to multi-organ dysfunction with a high mortality.
Case report: A pregnant woman at 29+1 weeks of gestational age had a fever. CT images of the chest showed lamellar consolidations in the inferior lobe of the right lung, light inflammation in the middle lobe of the right lung. Negative results were obtained from multiple times of blood and sputum culture. Next generation sequencing (NGS) results identified that Cps caused severe pneumonia, which was alleviated by specific antibiotic treatment.
Conclusion: Cps can cause severe pneumonia in the pregnant woman and be cured through precise antibiotic treatment. NGS is efficient in the rapid identification of pathogens and accurate diagnosis when bacteriological culture fails.
Keywords
chlamydia psittaci; pregnancy combined with severe pneumonia; next generation sequencing; case report
About this articleTitle
Pregnancy combined with severe pneumonia caused by Chlamydia psittaci infection — a case report
Journal
Issue
Article type
Clinical vignette
Pages
743-744
Published online
2021-09-27
Page views
6453
Article views/downloads
718
DOI
Pubmed
Bibliographic record
Ginekol Pol 2021;92(10):743-744.
Keywords
chlamydia psittaci
pregnancy combined with severe pneumonia
next generation sequencing
case report
Authors
Zhifen Yang
Shengpu Wang
Dong Xing
Huixin Zhang
References (13)- Mehta N, Chen K, Hardy E, et al. Respiratory disease in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2015; 29(5): 598–611.
- Mertz D, Geraci J, Winkup J, et al. Pregnancy as a risk factor for severe outcomes from influenza virus infection: A systematic review and meta-analysis of observational studies. Vaccine. 2017; 35(4): 521–528.
- Corsaro D, Greub G. Pathogenic potential of novel Chlamydiae and diagnostic approaches to infections due to these obligate intracellular bacteria. Clin Microbiol Rev. 2006; 19(2): 283–297.
- Yang J, Ling Y, Yuan J, et al. Isolation and characterization of peacock Chlamydophila psittaci infection in China. Avian Dis. 2011; 55(1): 76–81.
- Hogerwerf L, DE Gier B, Baan B, et al. Chlamydia psittaci (psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysis. Epidemiol Infect. 2017; 145(15): 3096–3105.
- Forbes JD, Knox NC, Peterson CL, et al. Highlighting Clinical Metagenomics for Enhanced Diagnostic Decision-making: A Step Towards Wider Implementation. Comput Struct Biotechnol J. 2018; 16: 108–120.
- Balsamo G, Maxted AM, Midla JW, et al. Compendium of Measures to Control Chlamydia psittaci Infection Among Humans (Psittacosis) and Pet Birds (Avian Chlamydiosis), 2017. J Avian Med Surg. 2017; 31(3): 262–282.
- Radomski N, Einenkel R, Müller A, et al. Chlamydia-host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaci. FEBS Lett. 2016; 590(21): 3920–3940.
- Mai N, Phu N, Nhu L, et al. Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future? Open Forum Infectious Diseases. 2017; 4(2).
- Brown JR, Bharucha T, Breuer J. Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases. J Infect. 2018; 76(3): 225–240.
- Gu L, Liu W, Ru M, et al. The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases. BMC Pulm Med. 2020; 20(1): 65.
- Knittler MR, Berndt A, Böcker S, et al. Chlamydia psittaci: new insights into genomic diversity, clinical pathology, host-pathogen interaction and anti-bacterial immunity. Int J Med Microbiol. 2014; 304(7): 877–893.
- Lee H, Yun KW, Lee HJ, et al. J, Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children[J]. Expert Rev Anti Infect Ther. 2018; 16(1): 23–34.
