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Research paper
Published online: 2021-11-23
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Prediction of preterm birth using PAMG-1 test: a single centre experience — preliminary report

Wojciech Cnota1, Agnieszka Jagielska1, Ewa Janowska1, Ewa Banas1, Rafal Kierach1, Malgorzata Nycz-Reska1, Bartosz Czuba1
DOI: 10.5603/GP.a2021.0171
Affiliations
  1. Clinical Department of Perinatology, Gynaecology and Obstetrics in Ruda Śląska, Medical University of Silesia, Ruda Śląska, Poland, Poland

open access

Ahead of Print
ORIGINAL PAPERS Obstetrics
Published online: 2021-11-23

Abstract

Objectives: Placental alpha microglobulin-1 (PAMG-1) is a novel biomarker detected in cervicovaginal discharge in patients threatened with preterm birth (PTB). This study aimed to show a single centre experience of assessment of imminent spontaneous PTB risk in patients with symptoms suggesting preterm labour (PTL).

Material and methods: The study group consisted of 46 women with singleton pregnancies between 24 + 0/7 and 33 + 6/7 weeks of gestation who presented with symptoms of threatened PTL, with cervical dilatation of < 3 cm, cervical length (CL) of < 30 mm and clinically intact fetal membranes. CL was measured via transvaginal ultrasound and the PAMG-1 test was performed in all of the objectives.

Results: Sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of prediction of PTB within seven days for CL were 100%, 11.11%, 5.88% and 100%, respectively. The PAMG-1 test SN, SP, PPV and NPV of the same endpoint were 50%, 80.56%, 12.5% and 96.67%, respectively.

Conclusions: PAMG-1 is a more accurate predictor of PTB when compared to CL. Routine use of both mentioned tests could allow identification of low-risk patients and reduction of rate of unnecessary hospitalizations and treatments.

Abstract

Objectives: Placental alpha microglobulin-1 (PAMG-1) is a novel biomarker detected in cervicovaginal discharge in patients threatened with preterm birth (PTB). This study aimed to show a single centre experience of assessment of imminent spontaneous PTB risk in patients with symptoms suggesting preterm labour (PTL).

Material and methods: The study group consisted of 46 women with singleton pregnancies between 24 + 0/7 and 33 + 6/7 weeks of gestation who presented with symptoms of threatened PTL, with cervical dilatation of < 3 cm, cervical length (CL) of < 30 mm and clinically intact fetal membranes. CL was measured via transvaginal ultrasound and the PAMG-1 test was performed in all of the objectives.

Results: Sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of prediction of PTB within seven days for CL were 100%, 11.11%, 5.88% and 100%, respectively. The PAMG-1 test SN, SP, PPV and NPV of the same endpoint were 50%, 80.56%, 12.5% and 96.67%, respectively.

Conclusions: PAMG-1 is a more accurate predictor of PTB when compared to CL. Routine use of both mentioned tests could allow identification of low-risk patients and reduction of rate of unnecessary hospitalizations and treatments.

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Keywords

preterm birth, preterm labou; placental alpha microglobulin-1 (PAMG-1); PartoSure; cervical length (CL)

About this article
Title

Prediction of preterm birth using PAMG-1 test: a single centre experience — preliminary report

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-11-23

DOI

10.5603/GP.a2021.0171

Keywords

preterm birth
preterm labou
placental alpha microglobulin-1 (PAMG-1)
PartoSure
cervical length (CL)

Authors

Wojciech Cnota
Agnieszka Jagielska
Ewa Janowska
Ewa Banas
Rafal Kierach
Malgorzata Nycz-Reska
Bartosz Czuba

References (17)
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