Vol 92, No 12 (2021)
Research paper
Published online: 2021-07-06

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Did the SARS-CoV-2 effect pregnancy complications?

Ozge Yucel Celik1, Şevki Çelen1, Yaprak Engin Üstün1
Pubmed: 34263916
Ginekol Pol 2021;92(12):872-877.


Objectives: This study aimed to evaluate the effect of SARS-CoV-2 on pregnancy complications, which increased compared to the same period before the pandemic.
Material and methods: This prospective study was conducted at Etlik Zübeyde Hanım Women›s Health Practices & Research Center between June 2020 and July 2020. The asymptomatic term PROM and miscarriage pregnant women were screened for SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) positivity by using IgM and IgG antibody tests. All the positive cases were confirmed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). All the patients answered 12 questions to determine their approach to COVID-19.
Results: Four of the 205 (2%) term PROM patients had positive anti-SARS-CoV-2 IgM antibody tests, one of the 205 (0.5%) term PROM patients had a positive anti-SARS-CoV-2 IgG antibody test, and one of the 205 (% 0.5) term PROM patients had positive anti-SARS-CoV-2 IgM and IgG antibody tests. All 230 miscarriage patients had negative IgM/IgG antibody tests. Four of the positive antibody cases had positive RT-PCR tests (2%) and were referred to a pandemic hospital. The patients thought that 93.2% and 95.6% of pregnant women with term PROM and miscarriage, respectively, SARS-CoV-2 would infect themselves, and 89.8% and 92.6%, respectively, would infect their children. The number of patients who would not consider pregnancy if they were not pregnant during this period was significantly higher in the term PROM (48.3%) compared to the miscarriage (27.8%) patients (p < 0.005).
Conclusions: No COVID-19 cases were determined in the asymptomatic miscarriage patients. In the asymptomatic term PROM patients, the effects of COVID were not observed.

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  1. Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224): 565–574.
  2. World Health Organization, Coronavirus disease (COVID-2019) situation reports 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (1.09.2020).
  3. General directorate of public health, COVİD-19 (SARS-CoV-2 infection) guideline Scientific Committee Report 2020. https://covid19bilgi.saglik.gov.tr/depo/rehberler/COVID-19_Rehberi.pdf?type=file (1.12.2020).
  4. Czeresnia RM, Trad AT, Britto IS, et al. SARS-CoV-2 and Pregnancy: A Review of the Facts. Rev Bras Ginecol Obstet. 2020; 42(9): 562–568.
  5. Ellington S, Strid P, Tong VT, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(25): 769–775.
  6. Elshafeey F, Magdi R, Hindi N, et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. Int J Gynaecol Obstet. 2020; 150(1): 47–52.
  7. Sutton D, Fuchs K, D'Alton M, et al. Universal Screening for SARS-CoV-2 in Women Admitted for Delivery. N Engl J Med. 2020; 382(22): 2163–2164.
  8. Breslin N, Baptiste C, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. American Journal of Obstetrics & Gynecology MFM. 2020; 2(2): 100118.
  9. Kennedy DM, Zambrano GJ, Wang Y, et al. Modeling the effects of intervention strategies on COVID-19 transmission dynamics. J Clin Virol. 2020; 128: 104440.
  10. Yan J, Guo J, Fan C, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020; 223(1): 111.e1–111.e14.
  11. Kirtsman M, Diambomba Y, Poutanen SM, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020; 192(24): E647–E650.
  12. Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020; 11(1): 3572.
  13. Kotlyar AM, Grechukhina O, Chen A, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021; 224(1): 35–53.e3.
  14. Huntley BJF, Huntley ES, Di Mascio D, et al. Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Obstet Gynecol. 2020; 136(2): 303–312.
  15. CELİK OY, OZKAN S, ERDOGAN K, et al. Did Pregnancy Complications Increase During The COVID-19 Pandemic Period? Medical Records. 2020.
  16. Campbell KH, Tornatore JM, Lawrence KE, et al. Prevalence of SARS-CoV-2 Among Patients Admitted for Childbirth in Southern Connecticut. JAMA. 2020; 323(24): 2520–2522.
  17. Goldfarb IT, Diouf K, Barth WH, et al. Universal SARS-CoV-2 testing on admission to the labor and delivery unit: Low prevalence among asymptomatic obstetric patients. Infect Control Hosp Epidemiol. 2020; 41(9): 1095–1096.
  18. Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020; 296(2): E32–E40.
  19. London V, McLaren R, Atallah F, et al. The Relationship between Status at Presentation and Outcomes among Pregnant Women with COVID-19. Am J Perinatol. 2020; 37(10): 991–994.
  20. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020; 395(10223): 497–506.
  21. Kumar D, Moore RM, Mercer BM, et al. The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. 2016; 42: 59–73.
  22. COVID-19 Situation Report Turkey 2020. https://sbsgm.saglik.gov.tr/TR,66424/covid-19-situation-report-turkey.html (10.12.2020).
  23. General Coronavirus Table. https://covid19.saglik.gov.tr/EN-69532/general-coronavirus-table.html (1.08.2020).
  24. Elshafeey F, Magdi R, Hindi N, et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. Int J Gynaecol Obstet. 2020; 150(1): 47–52.
  25. Yan J, Guo J, Fan C, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020; 223(1): 111.e1–111.e14.
  26. Deeks JJ, Dinnes J, Takwoingi Y, et al. Cochrane COVID-19 Diagnostic Test Accuracy Group. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst Rev. 2020; 6: CD013652.
  27. Long QX, Tang XJ, Shi QL, et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020; 26(8): 1200–1204.
  28. Durankuş F, Aksu E. Effects of the COVID-19 pandemic on anxiety and depressive symptoms in pregnant women: a preliminary study. J Matern Fetal Neonatal Med. 2020 [Epub ahead of print]: 1–7.
  29. Sinaci S, Ozden Tokalioglu E, Ocal D, et al. Does having a high-risk pregnancy influence anxiety level during the COVID-19 pandemic? Eur J Obstet Gynecol Reprod Biol. 2020; 255: 190–196.
  30. Qu F, Wu Y, Zhu YH, et al. The association between psychological stress and miscarriage: A systematic review and meta-analysis. Sci Rep. 2017; 7(1): 1731.
  31. Frazier T, Hogue CJ, Bonney EA, et al. Weathering the storm; a review of pre-pregnancy stress and risk of spontaneous abortion. Psychoneuroendocrinology. 2018; 92: 142–154.
  32. Nepomnaschy PA, Welch KB, McConnell DS, et al. Cortisol levels and very early pregnancy loss in humans. Proc Natl Acad Sci U S A. 2006; 103(10): 3938–3942.