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Published online: 2021-05-19
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Role of tumor location on high-grade serous ovarian cancer prognosis

Seval Ay, Deniz Tataroğlu Özyükseler, Mustafa Başak, Özgecan Dülgar, Serdar Arıcı, Mahmut Emre Yıldırım, Mahmut Gümüş
DOI: 10.5603/GP.a2021.0123
·
Pubmed: 34105739

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2021-05-19

Abstract

Objectives: Ovarian cancer is associated with the highest mortality of gynecologic cancers. Epidemiological and genetic factors of ovarian cancer development are clearly defined but prognostic factors have not been adequately identified. Right and left ovarian cancers seem to act different behaviors at high-grade serous ovarian cancer (HGSOC) prognosis. The aim of this study is to explain this prognostic role of its sidedness. The aim of this study is to explain this prognostic role of its sidedness.

Material and methods: We reviewed 160 consecutive patients with Figo stage 1-3 HGSOCs and undergone surgery at two high-volume hospitals. Prognostic effects of primary tumor location onset were evaluated in terms of 5-year disease free survival and overall survival rate.

Results: One hundred-sixty patients with ovarian cancer records were analyzed using the Kaplan-Meier method, that demonstrated a significant difference in the 5-year disease-free survival rates between right and left-sided cancers for all stages (44.6% vs 78.5%, p < 0.001). Also, there was significant difference in the 5-year overall survival rates between the two groups (71.1% vs 91.9%, p = 0.020).

Conclusions: Tumor location within the HGSOC seems to be a compelling prognostic factor ovarian cancer. Further prospective studies are needed in order to support our hypothesis.

Abstract

Objectives: Ovarian cancer is associated with the highest mortality of gynecologic cancers. Epidemiological and genetic factors of ovarian cancer development are clearly defined but prognostic factors have not been adequately identified. Right and left ovarian cancers seem to act different behaviors at high-grade serous ovarian cancer (HGSOC) prognosis. The aim of this study is to explain this prognostic role of its sidedness. The aim of this study is to explain this prognostic role of its sidedness.

Material and methods: We reviewed 160 consecutive patients with Figo stage 1-3 HGSOCs and undergone surgery at two high-volume hospitals. Prognostic effects of primary tumor location onset were evaluated in terms of 5-year disease free survival and overall survival rate.

Results: One hundred-sixty patients with ovarian cancer records were analyzed using the Kaplan-Meier method, that demonstrated a significant difference in the 5-year disease-free survival rates between right and left-sided cancers for all stages (44.6% vs 78.5%, p < 0.001). Also, there was significant difference in the 5-year overall survival rates between the two groups (71.1% vs 91.9%, p = 0.020).

Conclusions: Tumor location within the HGSOC seems to be a compelling prognostic factor ovarian cancer. Further prospective studies are needed in order to support our hypothesis.

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Keywords

disease free survival; high-grade serous ovarian cancer; left and right side cancers; overall survival; prognostic values; tumor location

About this article
Title

Role of tumor location on high-grade serous ovarian cancer prognosis

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-05-19

DOI

10.5603/GP.a2021.0123

Pubmed

34105739

Keywords

disease free survival
high-grade serous ovarian cancer
left and right side cancers
overall survival
prognostic values
tumor location

Authors

Seval Ay
Deniz Tataroğlu Özyükseler
Mustafa Başak
Özgecan Dülgar
Serdar Arıcı
Mahmut Emre Yıldırım
Mahmut Gümüş

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