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Vol 93, No 2 (2022)
Research paper
Published online: 2021-04-20
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Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

Renata Saucedo1, Jorge Valencia1, Luz Elena Moreno-González1, María Isabel Peña-Cano2, Alejandra Aranda-Martínez1, Yolanda García1, Mary Flor Díaz-Velázquez3, Marcelino Hernández-Valencia1
DOI: 10.5603/GP.a2021.0083
·
Pubmed: 33914332
·
Ginekol Pol 2022;93(2):126-133.
Affiliations
  1. Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico
  2. Faculty of Chemistry, Universidad Autonoma del Estado de Mexico, State of Mexico, Mexico
  3. Hospital of Gynecology and Obstetrics 3, Medical Center La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico

open access

Vol 93, No 2 (2022)
ORIGINAL PAPERS Obstetrics
Published online: 2021-04-20

Abstract

Objectives: Maternal obesity increases the risk of gestational diabetes mellitus (GDM) and is positively correlated with neonatal obesity increasing the risk of adiposity in both young and adult offspring. Maternal secreted factors from adipose tissue such as adipokines and inflammatory cytokines may regulate fetal growth. This study investigated associations between maternal adipokines and inflammatory markers at late gestation, and neonatal anthropometric characteristics in mothers with and without GDM. Material and methods: The study included 65 women with GDM and 65 pregnant women with normal glucose tolerance evaluated at the time of term elective Caesarean section. Adiponectin, leptin, resistin, adipsin, neutrophil gelatinase-associated lipocalin (NGAL), nerve growth factor (NGF), monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in maternal serum by the multiplex immunoassay using Magpix technology. C-reactive protein (CRP) was measured with a particle-enhanced turbidimetric immunoassay and neonatal anthropometric variables were assessed. The association of birthweight with individual biomarkers was analyzed using multivariate logistic regression adjusted for maternal factors. Results: Adiponectin, leptin, resistin, adipsin, NGAL and NGF were not significantly associated with higher birthweight. The maternal factors in association with higher birthweight observed in GDM were CRP, MCP-1 and TNF-alpha levels. Regression analysis showed that TNF-alpha was an independent risk factor for higher birthweight (p = 0.046). Conclusions: These results suggest an involvement of maternal inflammatory markers at late gestation and fetal growth in mothers with GDM, and that TNF-alpha could play a major role.

Abstract

Objectives: Maternal obesity increases the risk of gestational diabetes mellitus (GDM) and is positively correlated with neonatal obesity increasing the risk of adiposity in both young and adult offspring. Maternal secreted factors from adipose tissue such as adipokines and inflammatory cytokines may regulate fetal growth. This study investigated associations between maternal adipokines and inflammatory markers at late gestation, and neonatal anthropometric characteristics in mothers with and without GDM. Material and methods: The study included 65 women with GDM and 65 pregnant women with normal glucose tolerance evaluated at the time of term elective Caesarean section. Adiponectin, leptin, resistin, adipsin, neutrophil gelatinase-associated lipocalin (NGAL), nerve growth factor (NGF), monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in maternal serum by the multiplex immunoassay using Magpix technology. C-reactive protein (CRP) was measured with a particle-enhanced turbidimetric immunoassay and neonatal anthropometric variables were assessed. The association of birthweight with individual biomarkers was analyzed using multivariate logistic regression adjusted for maternal factors. Results: Adiponectin, leptin, resistin, adipsin, NGAL and NGF were not significantly associated with higher birthweight. The maternal factors in association with higher birthweight observed in GDM were CRP, MCP-1 and TNF-alpha levels. Regression analysis showed that TNF-alpha was an independent risk factor for higher birthweight (p = 0.046). Conclusions: These results suggest an involvement of maternal inflammatory markers at late gestation and fetal growth in mothers with GDM, and that TNF-alpha could play a major role.

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Keywords

gestational diabetes mellitus; adipokines; cytokines; maternal obesity; birthweight

About this article
Title

Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

Journal

Ginekologia Polska

Issue

Vol 93, No 2 (2022)

Article type

Research paper

Pages

126-133

Published online

2021-04-20

Page views

6447

Article views/downloads

1360

DOI

10.5603/GP.a2021.0083

Pubmed

33914332

Bibliographic record

Ginekol Pol 2022;93(2):126-133.

Keywords

gestational diabetes mellitus
adipokines
cytokines
maternal obesity
birthweight

Authors

Renata Saucedo
Jorge Valencia
Luz Elena Moreno-González
María Isabel Peña-Cano
Alejandra Aranda-Martínez
Yolanda García
Mary Flor Díaz-Velázquez
Marcelino Hernández-Valencia

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