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Published online: 2021-04-27
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Prognosis of the patients suffered from uterine carcinosarcoma from rural and urban areas

Anna Danska-Bidzinska, Anna Nasierowska-Guttmejer, Elwira Bakula-Zalewska, Mariusz Bidzinski, Waldemar Wierzba
DOI: 10.5603/GP.a2021.0067
·
Pubmed: 33914324

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2021-04-27

Abstract

Objectives: Uterine carcinosarcoma is a very aggressive neoplasm. Patients’ median age at diagnosis ranges from 62 to 67 years. The aim of this study was to compare treatment results and prognostic factors for residents of urban and rural areas suffering from uterine carcinosarcoma.

Material and methods: Clinical outcomes of 58 uterine carcinosarcoma patients treated in one institution were assessed: 25 residents of rural and 33 of urban areas. All the patients were treated by using surgery followed by chemotherapy (48 pts) or radiotherapy (10 pts). Standard chemotherapy regimen comprised of paclitaxel 175 mg/m2 and carboplatin on day one at area under curve (AUC) six every 21 days. Radiotherapy was performed by combined treatment – tele and brachytherapy. External beam pelvic radiation therapy (EBRT) once a day, five days a week with a daily fraction size of 1.8 Gy over five weeks at cumulative dose 50.4 Gy was the first part of adjuvant treatment. High-dose-rate (HDR) brachytherapy at dose 22.5 Gy was the second part of radiotherapy.

Results: A strong correlation between tumor diameter and the presence of lymph node metastasis was observed. Tumor size greater then 4.5 cm correlated with presence of node involvement and this parameter was statistically significant (p = 0.015). There was no significant correlation between other analyzed clinical factors and overall survival. In the period 2004 – 2010 43.5% (10/23) and 50% (14/28) of rural and urban residents, respectively, died due to carcinosarcoma progression.

Conclusion: Uterine carcinosarcoma patients in rural and urban areas seem to have similar outcomes. 

Abstract

Objectives: Uterine carcinosarcoma is a very aggressive neoplasm. Patients’ median age at diagnosis ranges from 62 to 67 years. The aim of this study was to compare treatment results and prognostic factors for residents of urban and rural areas suffering from uterine carcinosarcoma.

Material and methods: Clinical outcomes of 58 uterine carcinosarcoma patients treated in one institution were assessed: 25 residents of rural and 33 of urban areas. All the patients were treated by using surgery followed by chemotherapy (48 pts) or radiotherapy (10 pts). Standard chemotherapy regimen comprised of paclitaxel 175 mg/m2 and carboplatin on day one at area under curve (AUC) six every 21 days. Radiotherapy was performed by combined treatment – tele and brachytherapy. External beam pelvic radiation therapy (EBRT) once a day, five days a week with a daily fraction size of 1.8 Gy over five weeks at cumulative dose 50.4 Gy was the first part of adjuvant treatment. High-dose-rate (HDR) brachytherapy at dose 22.5 Gy was the second part of radiotherapy.

Results: A strong correlation between tumor diameter and the presence of lymph node metastasis was observed. Tumor size greater then 4.5 cm correlated with presence of node involvement and this parameter was statistically significant (p = 0.015). There was no significant correlation between other analyzed clinical factors and overall survival. In the period 2004 – 2010 43.5% (10/23) and 50% (14/28) of rural and urban residents, respectively, died due to carcinosarcoma progression.

Conclusion: Uterine carcinosarcoma patients in rural and urban areas seem to have similar outcomes. 

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Keywords

carcinosarcoma; rural area; urban area; overall survival; overall survival

About this article
Title

Prognosis of the patients suffered from uterine carcinosarcoma from rural and urban areas

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-04-27

DOI

10.5603/GP.a2021.0067

Pubmed

33914324

Keywords

carcinosarcoma
rural area
urban area
overall survival
overall survival

Authors

Anna Danska-Bidzinska
Anna Nasierowska-Guttmejer
Elwira Bakula-Zalewska
Mariusz Bidzinski
Waldemar Wierzba

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