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Role of platelet indices in prediction of preeclampsia
, 2, 2, 3, 2
Affiliations- Bursa Yıldırım Special Doruk Hospital, Bursa Turkey
- HSU Bursa Yüksek İhtisas Training and Research Hospital, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi Mimar Sina Mah Emniyet Cad Yıldırım, Bursa, Turkey
- Yozgat City Hospital Department of Obstetrics and Gynecology, Yozgat, Turkey
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Abstract
Objectives: To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.
Material and methods: This retrospective case- control study included 257 preeclampsia patients and 264 healthy pregnant women as the control group. The groups were compared in terms of platelet count (PC), mean platelet volume (MPV), platelet distribution range (PDW), plateletcrit (Pct), Pct / MPV ratio and PC / MPV ratio.
Results: Between the preeclampsia group and the control group; mean platelet count (227.22 ± 78.58 vs 236.69 ± 64.30), plateletcrit (PCT) (0.21 ± 0.06 vs 0.24 ± 0.27), and platelet distribution width (PDW) (17.11 ± 0.80 vs 17.29 ± 0.82) were not significantly different (p> 0.05). However, MPV values were significantly higher in the preclampsia group compared to the control group (9.66 ± 1.62 and 8.92 ± 1.33, respectively) (p < 0.001). In our study, the optimum cut-off value of MPV was 9.15 with 58.7% sensitivity and 61.7% specificity for the prediction of preeclampsia. Pct/MPV ratio (0.02 ± 0.007 vs 0.027 ± 0.029) ( p = 0.01) and PC/MPV ratio ( 24.63 ± 10.90 vs 27.63 ± 10.24) (p = 0.001) were significantly lower in the preeclampsia group than in the control group.
Conslusions: In preeclampsia, changes in platelet functions, destruction and production lead to changes in platelet indices. Compared with normal healthy pregnant women, preeclamptic pregnant women have higher MPV values. In preeclampsia prediction, MPV and PC/MPV ratio are promising as a diagnostic parameter.
Abstract
Objectives: To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.
Material and methods: This retrospective case- control study included 257 preeclampsia patients and 264 healthy pregnant women as the control group. The groups were compared in terms of platelet count (PC), mean platelet volume (MPV), platelet distribution range (PDW), plateletcrit (Pct), Pct / MPV ratio and PC / MPV ratio.
Results: Between the preeclampsia group and the control group; mean platelet count (227.22 ± 78.58 vs 236.69 ± 64.30), plateletcrit (PCT) (0.21 ± 0.06 vs 0.24 ± 0.27), and platelet distribution width (PDW) (17.11 ± 0.80 vs 17.29 ± 0.82) were not significantly different (p> 0.05). However, MPV values were significantly higher in the preclampsia group compared to the control group (9.66 ± 1.62 and 8.92 ± 1.33, respectively) (p < 0.001). In our study, the optimum cut-off value of MPV was 9.15 with 58.7% sensitivity and 61.7% specificity for the prediction of preeclampsia. Pct/MPV ratio (0.02 ± 0.007 vs 0.027 ± 0.029) ( p = 0.01) and PC/MPV ratio ( 24.63 ± 10.90 vs 27.63 ± 10.24) (p = 0.001) were significantly lower in the preeclampsia group than in the control group.
Conslusions: In preeclampsia, changes in platelet functions, destruction and production lead to changes in platelet indices. Compared with normal healthy pregnant women, preeclamptic pregnant women have higher MPV values. In preeclampsia prediction, MPV and PC/MPV ratio are promising as a diagnostic parameter.
Keywords
mean platelet volume; platelet count; preeclampsia
About this articleTitle
Role of platelet indices in prediction of preeclampsia
Journal
Issue
Article type
Research paper
Pages
792-796
Published online
2021-05-26
Page views
7708
Article views/downloads
1593
DOI
Pubmed
Bibliographic record
Ginekol Pol 2021;92(11):792-796.
Keywords
mean platelet volume
platelet count
preeclampsia
Authors
Muzaffer Temur
Fatma Nurgül Taşgöz
Tayfur Çift
Gülçin Serpim
Emin Üstünyurt
References (30)- Williams ML. Long-term hospitalization of women with high-risk pregnancies. A nurse's viewpoint. J Obstet Gynecol Neonatal Nurs. 1986; 15(1): 17–21.
- Young B, Levine R, Karumanchi S. Pathogenesis of Preeclampsia. Annual Review of Pathology: Mechanisms of Disease. 2010; 5(1): 173–192.
- Romero R, Lockwood C, Oyarzun E, et al. Toxemia: new concepts in an old disease. Semin Perinatol. ; 12: 302–323.
- Tygart SG, McRoyan DK, Spinnato JA, et al. Longitudinal study of platelet indices during normal pregnancy. Am J Obstet Gynecol. 1986; 154(4): 883–887.
- Ceyhan T, Beyan C, Başer I, et al. The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol. 2006; 85: 320.
- Stubbs TM, Lazarchick J, Van Dorsten JP, et al. Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia. Am J Obstet Gynecol. 1986; 155(2): 263–265.
- Kanat-Pektas M, Yesildager U, Tuncer N, et al. Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre-eclampsia? J Obstet Gynaecol Res. 2014; 40(7): 1840–1845.
- ACOG Practice Bulletin No. 33: Diagnosis and Management of Preeclampsia and Eclampsia. Obstetrics & Gynecology. 2002; 99(1): 159–167.
- Steegers E, Dadelszen Pv, Duvekot J, et al. Pre-eclampsia. The Lancet. 2010; 376(9741): 631–644.
- Saftlas AF, Beydoun H, Triche E. Immunogenetic determinants of preeclampsia and related pregnancy disorders: a systematic review. Obstet Gynecol. 2005; 106(1): 162–172.
- Yucel B, Ustun B. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy Hypertens. 2017; 7: 29–32.
- Laresgoiti-Servitje E, Gómez-López N, Olson DM. An immunological insight into the origins of pre-eclampsia. Hum Reprod Update. 2010; 16(5): 510–524.
- Hutt R, Ogunniyi SO, Sullivan MH, et al. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol. 1994; 83(1): 146–149.
- Kurtoglu E, Kokcu A, Celik H, et al. Validity of platelet indices in predicting the risk of developing preeclampsia. J Exp Clin Med. 2016; 33(2): 57–61.
- Yang SW, Cho SH, Kwon HS, et al. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2014; 175: 107–111.
- Mannaerts D, Heyvaert S, De Cordt C, et al. Are neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? J Matern Fetal Neonatal Med. 2019; 32(9): 1412–1419.
- Doğan K, Guraslan H, Senturk MB, et al. Can Platelet Count and Platelet Indices Predict the Risk and the Prognosis of Preeclampsia? Hypertens Pregnancy. 2015; 34(4): 434–442.
- Han L, Liu X, Li H, et al. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PLoS One. 2014; 9(12): e114488.
- Freitas LG, Alpoim PN, Komatsuzaki F, et al. Preeclampsia: are platelet count and indices useful for its prognostic? Hematology. 2013; 18(6): 360–364.
- Moraes D, Munhoz TP, Pinheiro da Costa BE, et al. Immature platelet fraction in hypertensive pregnancy. Platelets. 2016; 27(4): 333–337.
- Dundar O, Yoruk P, Tutuncu L, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn. 2008; 28(11): 1052–1056.
- Sezer S, Küçük M, Yüksel H, et al. Preeklamptik gebelerde trombosit parametreleri. Pam Tıp Derg. 2011; 4(2): 66–71.
- Makuyana D, Mahomed K, Shukusho FD, et al. Liver and kidney function tests in normal and pre-eclamptic gestation--a comparison with non-gestational reference values. Cent Afr J Med. 2002; 48(5-6): 55–59.
- Bath P, Butterworth RJ. Platelet size. Blood Coagulation & Fibrinolysis. 1996; 7(2): 157–161.
- AlSheeha MA, Alaboudi RS, Alghasham MA, et al. Platelet count and platelet indices in women with preeclampsia. Vasc Health Risk Manag. 2016; 12: 477–480.
- Saleh AA, Bottoms SF, Farag AM, et al. Markers for endothelial injury, clotting and platelet activation in preeclampsia. Arch Gynecol Obstet. 1992; 251(3): 105–110.
- Mouna K, Doddagowda SM, Junjegowda K, et al. Changes in Haematological Parameters in Newborns Born to Preeclamptic Mothers - A Case Control Study in a Rural Hospital. J Clin Diagn Res. 2017; 11(7): EC26–EC29.
- Jacquemyn Y, Zemtsova O. Risk factors and prediction of preeclampsia. Acta Clin Belg. 2010; 65(1): 1–12.
- Zupan-Simunek V. [Prognosis in newborns after mother's preeclampsia]. Ann Fr Anesth Reanim. 2010; 29(5): e135–e139.
- Bellos I, Fitrou G, Pergialiotis V, et al. Mean platelet volume values in preeclampsia: A systematic review and meta-analysis. Pregnancy Hypertens. 2018; 13: 174–180.
