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Published online: 2021-04-20
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Can prophylactic transvaginal cervical cerclage improve pregnancy outcome in patients receiving cervical conization? A meta-analysis

Ting Wang, Ruoan Jiang, Yingsha Yao, Xiufeng Huang
DOI: 10.5603/GP.a2021.0020
·
Pubmed: 33914333

open access

Ahead of Print
ORIGINAL PAPERS Obstetrics
Published online: 2021-04-20

Abstract

Objectives: Cervical conization could increase the risk of cervical insufficiency. This study systematically evaluated the value of prophylactic transvaginal cervical cerclage following cervical conization with regards to pregnancy outcome. Material and methods: We performed a systematic review of the literature, using Web of Science, and Embase, the published time ranged from the date that database established to December 2019. Pregnant patients, who had a previous history of cervical conization for CIN or early cervical cancer, were enrolled. Two researchers searched these databases and estimated the included studies' quality independently, depending on the same criteria. Results: Our meta-analysis is incorporate 3560 cases eventually. Meta-analysis showed that when compared to the no-cerclage group, the risk ratio (RR) of preterm birth in the prophylactic transvaginal cervical cerclage group was 1.85 [95% confidence interval [CI]: 1.22–2.80; p = 0.004); the RR of premature rupture of membranes was 1.5 (95% CI: 1.17–1.93; p = 0.001). Conclusions: The rates of preterm birth were significantly higher in women following cervical conization with transvaginal cerclage than those without cerclage.

Abstract

Objectives: Cervical conization could increase the risk of cervical insufficiency. This study systematically evaluated the value of prophylactic transvaginal cervical cerclage following cervical conization with regards to pregnancy outcome. Material and methods: We performed a systematic review of the literature, using Web of Science, and Embase, the published time ranged from the date that database established to December 2019. Pregnant patients, who had a previous history of cervical conization for CIN or early cervical cancer, were enrolled. Two researchers searched these databases and estimated the included studies' quality independently, depending on the same criteria. Results: Our meta-analysis is incorporate 3560 cases eventually. Meta-analysis showed that when compared to the no-cerclage group, the risk ratio (RR) of preterm birth in the prophylactic transvaginal cervical cerclage group was 1.85 [95% confidence interval [CI]: 1.22–2.80; p = 0.004); the RR of premature rupture of membranes was 1.5 (95% CI: 1.17–1.93; p = 0.001). Conclusions: The rates of preterm birth were significantly higher in women following cervical conization with transvaginal cerclage than those without cerclage.

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Keywords

cervical conization; prophylactic cervical cerclage; preterm birth; premature rupture of membranes

About this article
Title

Can prophylactic transvaginal cervical cerclage improve pregnancy outcome in patients receiving cervical conization? A meta-analysis

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-04-20

DOI

10.5603/GP.a2021.0020

Pubmed

33914333

Keywords

cervical conization
prophylactic cervical cerclage
preterm birth
premature rupture of membranes

Authors

Ting Wang
Ruoan Jiang
Yingsha Yao
Xiufeng Huang

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