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Research paper
Published online: 2021-03-10
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Evaluation of the presence of SARS-COV-2 in the vaginal fluid of reproductive-aged women

Hilal Uslu Yuvacı, Mehmet Musa Aslan, Osman Köse, Nermin Akdemir, Hande Toptan, Arif Serhan Cevrioğlu, Mustafa Altındiş, Mehmet Köroğlu
DOI: 10.5603/GP.a2021.0018

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2021-03-10

Abstract

Objectives: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is mainly transmitted through respiration and
direct contact. The status of the infection in the female genital system is still unknown. The study aimed to evaluate whether
SARS-CoV-2 is present in the vaginal fluid of women with COVID-19 infection in reproductive period.
Material and methods: Women who were between the ages of 18–50 years and clinically confirmed to have COVID-19 infection
at our hospital between 20 April–31 May 2020 were included in the study. Women who were in their menstrual
cycle during the study and who had a known cervical intraepithelial lesion and/or cancer, sexually transmitted disease and
history and/or symptoms of vaginitis were excluded from the study. In patients in whom no pathology was detected during
the examination, a sample was taken from the vaginal fluid for PCR by using Dacron tip swab. Analysis was performed with
Genesig Real-Time PCR COVID-19 kit (Primer Design, England).
Results: Eighteen women who were in reproductive period and diagnosed with severe COVID-19 pneumonia were included
in the study. The mean age of the patients was 38.16 ± 8.54. None of the patients were in their menopause period. The
clinical symptoms of these women were similar to those of confirmed severe COVID-19 cases. SARS-CoV-2 was found to
be negative in the samples taken from the vaginal fluid in all patients.
Conclusions: SARS-CoV-2 virus was not detected in the vaginal fluid of the patients who tested positive for COVID-19 in
reproductive period.

Abstract

Objectives: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is mainly transmitted through respiration and
direct contact. The status of the infection in the female genital system is still unknown. The study aimed to evaluate whether
SARS-CoV-2 is present in the vaginal fluid of women with COVID-19 infection in reproductive period.
Material and methods: Women who were between the ages of 18–50 years and clinically confirmed to have COVID-19 infection
at our hospital between 20 April–31 May 2020 were included in the study. Women who were in their menstrual
cycle during the study and who had a known cervical intraepithelial lesion and/or cancer, sexually transmitted disease and
history and/or symptoms of vaginitis were excluded from the study. In patients in whom no pathology was detected during
the examination, a sample was taken from the vaginal fluid for PCR by using Dacron tip swab. Analysis was performed with
Genesig Real-Time PCR COVID-19 kit (Primer Design, England).
Results: Eighteen women who were in reproductive period and diagnosed with severe COVID-19 pneumonia were included
in the study. The mean age of the patients was 38.16 ± 8.54. None of the patients were in their menopause period. The
clinical symptoms of these women were similar to those of confirmed severe COVID-19 cases. SARS-CoV-2 was found to
be negative in the samples taken from the vaginal fluid in all patients.
Conclusions: SARS-CoV-2 virus was not detected in the vaginal fluid of the patients who tested positive for COVID-19 in
reproductive period.

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Keywords

coronavirus; SARS-CoV-2; vaginal fluid

About this article
Title

Evaluation of the presence of SARS-COV-2 in the vaginal fluid of reproductive-aged women

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-03-10

DOI

10.5603/GP.a2021.0018

Keywords

coronavirus
SARS-CoV-2
vaginal fluid

Authors

Hilal Uslu Yuvacı
Mehmet Musa Aslan
Osman Köse
Nermin Akdemir
Hande Toptan
Arif Serhan Cevrioğlu
Mustafa Altındiş
Mehmet Köroğlu

References (11)
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