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Chaos and cancers. Theories concerning carcinogenesis
, 2, 1, 3
Affiliations- Department of Gynecologic Oncology and Gynecology of the Medical University of Lublin, Poland
- Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland
- Department of Molecular Virology, Institute of Experimental Biology, Adam Mickiewicz University in Poznan, Poland
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Abstract
One of the most intriguing problems in biomedical sciences is the theory explaining cancer formation. It is known that
cancer is the result of many molecular processes, the presence of oncogenic factors and the loss of apoptosis of affected
cells. We currently have hypotheses based on carcinogenesis because of a single cell gene mutation, i.e. somatic mutation
theory (SMT), or disorders in tissue architecture and intercellular communication called (TOFT) Tissue Organization Field
Theory. An attempt to combine these separate and compatible cause and effect pathways into one unified theory of cancer
transformation is the theory of chaotic adaptation. The new interpretative model is the systemic-evolution theory of cancer
(SETOC) which postulates disintegration between the symbiosis of “energy” and “information” in normal cells. There are also
epidemiological studies confirming that some types of cancer arise from viral infection. So, let us ask the question, can one
hypothesis explain all the features of cancer?
Abstract
One of the most intriguing problems in biomedical sciences is the theory explaining cancer formation. It is known that
cancer is the result of many molecular processes, the presence of oncogenic factors and the loss of apoptosis of affected
cells. We currently have hypotheses based on carcinogenesis because of a single cell gene mutation, i.e. somatic mutation
theory (SMT), or disorders in tissue architecture and intercellular communication called (TOFT) Tissue Organization Field
Theory. An attempt to combine these separate and compatible cause and effect pathways into one unified theory of cancer
transformation is the theory of chaotic adaptation. The new interpretative model is the systemic-evolution theory of cancer
(SETOC) which postulates disintegration between the symbiosis of “energy” and “information” in normal cells. There are also
epidemiological studies confirming that some types of cancer arise from viral infection. So, let us ask the question, can one
hypothesis explain all the features of cancer?
Keywords
carcinogenesis; somatic mutation theory; tissue organization field theory; chaotic adaptation; systemic-evolution theory of cancer; genome; chaos; information
About this articleTitle
Chaos and cancers. Theories concerning carcinogenesis
Journal
Issue
Article type
Review paper
Pages
318-321
Published online
2021-03-18
Page views
1216
Article views/downloads
1434
DOI
Pubmed
Bibliographic record
Ginekol Pol 2021;92(4):318-321.
Keywords
carcinogenesis
somatic mutation theory
tissue organization field theory
chaotic adaptation
systemic-evolution theory of cancer
genome
chaos
information
Authors
Wojciech Kwasniewski
Aleksandra Stupak
Jan Kotarski
Anna Gozdzicak-Jozefiak
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