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Review paper
Published online: 2020-10-20
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Peripartum cardiomyopathy — a cardiovascular disease in pregnancy and puerperium. The actual state of knowledge, challenges, and perspectives

Karolina E. Kryczka, Marcin Demkow, Zofia Dzielinska
DOI: 10.5603/GP.a2020.0171
·
Pubmed: 33084016

open access

Ahead of Print
REVIEW PAPERS Obstetrics
Published online: 2020-10-20

Abstract

Peripartum cardiomyopathy (PPCM) is an idiopathic, multifactor cause of heart failure occurring at the end of pregnancy
or in the first months after delivery. Although the prevalence of the disease is increasing, the awareness of both physicians
and patients is rather low. Symptoms of PPCM are unspecific, making a prompt diagnosis even more difficult. In severe
functional insufficiency and dilatation of the left ventricle, the recovery rate is particularly low. Therefore, the later PPCM
is diagnosed, the more severe heart failure, and the worse the patient’s outcome.
Despite the increasing frequency of PPCM, the exact pathophysiology and predictors of outcome are still not well determined.
Therapeutic management in patients with PPCM remains a challenge, requiring a multidisciplinary approach.
At the base of the disease lies dysfunction of microcirculation with 16-kDa prolactin as the main trigger of this state. Therefore,
adding bromocriptine to standard heart failure pharmacotherapy may be particularly beneficial.
In this review, we present the current state of knowledge and diagnostic and management recommendations and perspectives.

Abstract

Peripartum cardiomyopathy (PPCM) is an idiopathic, multifactor cause of heart failure occurring at the end of pregnancy
or in the first months after delivery. Although the prevalence of the disease is increasing, the awareness of both physicians
and patients is rather low. Symptoms of PPCM are unspecific, making a prompt diagnosis even more difficult. In severe
functional insufficiency and dilatation of the left ventricle, the recovery rate is particularly low. Therefore, the later PPCM
is diagnosed, the more severe heart failure, and the worse the patient’s outcome.
Despite the increasing frequency of PPCM, the exact pathophysiology and predictors of outcome are still not well determined.
Therapeutic management in patients with PPCM remains a challenge, requiring a multidisciplinary approach.
At the base of the disease lies dysfunction of microcirculation with 16-kDa prolactin as the main trigger of this state. Therefore,
adding bromocriptine to standard heart failure pharmacotherapy may be particularly beneficial.
In this review, we present the current state of knowledge and diagnostic and management recommendations and perspectives.

Get Citation

Keywords

peripartum cardiomyopathy; pregnancy; bromocriptine

About this article
Title

Peripartum cardiomyopathy — a cardiovascular disease in pregnancy and puerperium. The actual state of knowledge, challenges, and perspectives

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Review paper

Published online

2020-10-20

DOI

10.5603/GP.a2020.0171

Pubmed

33084016

Keywords

peripartum cardiomyopathy
pregnancy
bromocriptine

Authors

Karolina E. Kryczka
Marcin Demkow
Zofia Dzielinska

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