Vol 92, No 1 (2021)
Review paper
Published online: 2021-01-29

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Metformin administration during pregnancy — current insight

Milena Skibinska12, Monika Zurawska- Klis2, Michal Krekora1, Katarzyna Cypryk2
Pubmed: 33576490
Ginekol Pol 2021;92(1):46-50.


The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicine
reducing insulin resistance appears to be promising.
Currently, the majority of medical associations do not recommend using metformin during pregnancy as the first-line of
therapy when the diet regimen is insufficient for glycaemic control. However, they do allow its administration if there is
no possibility of insulin treatment.
There is some evidence which suggests that using metformin during pregnancy is not related to an increased risk of obstetric
complications during delivery and that its influence on the foetus can be beneficial.
Since metformin crosses the placenta, the major argument for cautious use of this drug are the potential long-term effects
of the treatment for the child and its development in later life.
In this article, the authors attempt to discuss the use of metformin during pregnancy and the safety of the treatment in
the light of current studies and recommendations.

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