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ORIGINAL PAPERS Gynecology
Published online: 2020-09-14
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Subcutaneous rifampicin versus povidone-iodine for the prevention of incisional surgical site infections following gynecologic oncology surgery — a prospective, randomized, controlled trial

Özge Kömürcü Karuserci, Özcan Balat
DOI: 10.5603/GP.a2020.0134

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2020-09-14

Abstract

Objectives: Surgical site infection (SSI) following gynecologic oncology surgery is a severe problem for both patient
and surgeon in terms of increasing morbidity, length of hospital stay, anxiety, and costs. In this prospective, randomized,
controlled study we investigated the effect of subcutaneous rifampicin and povidone-iodine on incisional SSI following
gynecologic oncology surgery.
Material and methods: Three hundred patients scheduled for abdominal surgery due to any malign gynecological pathology
were randomly assigned into one of three groups of 100 members each, as follows: the subcutaneous tissue was
irrigated with saline in Group 1; saline + 10% povidone iodine in Group 2; saline + rifampicin in Group 3. Patients were
invited to follow-up once every 10 days in a 30-day period for evaluation. Patients who developed a superficial incisional
SSI were recorded.
Results: No significant relationship was observed between the SSI and the subcutaneous agents used (p = 0.332). It was
observed that there was a statistically significant increase in the rate of incisional surgical site infections as the period
of hospitalization (p = 0.044), patient’s age (p = 0.003), existence of comorbidities (p = 0.001), and perioperative blood
transfusion (p = 0.021) increased.
Conclusions: Subcutaneous agents are not effective in preventing surgical site infections after gynecologic oncology
surgeries. Further large-scale prospective randomized controlled studies may provide other options to prevent SSIs.

Abstract

Objectives: Surgical site infection (SSI) following gynecologic oncology surgery is a severe problem for both patient
and surgeon in terms of increasing morbidity, length of hospital stay, anxiety, and costs. In this prospective, randomized,
controlled study we investigated the effect of subcutaneous rifampicin and povidone-iodine on incisional SSI following
gynecologic oncology surgery.
Material and methods: Three hundred patients scheduled for abdominal surgery due to any malign gynecological pathology
were randomly assigned into one of three groups of 100 members each, as follows: the subcutaneous tissue was
irrigated with saline in Group 1; saline + 10% povidone iodine in Group 2; saline + rifampicin in Group 3. Patients were
invited to follow-up once every 10 days in a 30-day period for evaluation. Patients who developed a superficial incisional
SSI were recorded.
Results: No significant relationship was observed between the SSI and the subcutaneous agents used (p = 0.332). It was
observed that there was a statistically significant increase in the rate of incisional surgical site infections as the period
of hospitalization (p = 0.044), patient’s age (p = 0.003), existence of comorbidities (p = 0.001), and perioperative blood
transfusion (p = 0.021) increased.
Conclusions: Subcutaneous agents are not effective in preventing surgical site infections after gynecologic oncology
surgeries. Further large-scale prospective randomized controlled studies may provide other options to prevent SSIs.

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Keywords

gynecologic surgical oncology; povidone-iodine; rifampicin; surgical site infection

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Title

Subcutaneous rifampicin versus povidone-iodine for the prevention of incisional surgical site infections following gynecologic oncology surgery — a prospective, randomized, controlled trial

Journal

Ginekologia Polska

Issue

Ahead of Print

Published online

2020-09-14

DOI

10.5603/GP.a2020.0134

Keywords

gynecologic surgical oncology
povidone-iodine
rifampicin
surgical site infection

Authors

Özge Kömürcü Karuserci
Özcan Balat

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