open access

Vol 91, No 12 (2020)
Research paper
Published online: 2020-12-31
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Expression and significance of Parkinson disease protein 7 in placental, serum and umbilical cord blood in preeclampsia

Tingting Yang1, Jianying Yan1, Qing Han1, Qinjian Zhang1, Qiuping Liao1
·
Pubmed: 33447996
·
Ginekol Pol 2020;91(12):764-768.
Affiliations
  1. Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fujian, China

open access

Vol 91, No 12 (2020)
ORIGINAL PAPERS Obstetrics
Published online: 2020-12-31

Abstract

Objectives: To study the role of changes in the expression of human Parkinson’s disease protein 7 (PARK7/DJ-1) in preeclampsia.
Material and methods: We selected 120 gravidas, including 60 cases of severe preeclampsia group and control group, and
divided into early onset preeclampsia group (< 34 weeks), late onset preeclampsia group (≥ 34 weeks) and control group
according to the onset of pregnancy. The expression level of DJ-1 was detected by ELISA. The expression level of DJ-1 in
placenta tissue of gravidas was detected by Western-blot and RT-PCR.
Results: The level of DJ-1 in serum and cord blood of preeclampsia group was higher than that of control group. The relative
level of DJ-1 protein and DJ-1 mRNA in placenta tissue of preeclampsia group was higher than that of control group.
Conclusions: The expression level of DJ-1 in serum, umbilical cord blood and placenta tissue increased in preeclampsia
patients, suggesting that DJ-1 may take part in the pathophysiology process of preeclampsia.

Abstract

Objectives: To study the role of changes in the expression of human Parkinson’s disease protein 7 (PARK7/DJ-1) in preeclampsia.
Material and methods: We selected 120 gravidas, including 60 cases of severe preeclampsia group and control group, and
divided into early onset preeclampsia group (< 34 weeks), late onset preeclampsia group (≥ 34 weeks) and control group
according to the onset of pregnancy. The expression level of DJ-1 was detected by ELISA. The expression level of DJ-1 in
placenta tissue of gravidas was detected by Western-blot and RT-PCR.
Results: The level of DJ-1 in serum and cord blood of preeclampsia group was higher than that of control group. The relative
level of DJ-1 protein and DJ-1 mRNA in placenta tissue of preeclampsia group was higher than that of control group.
Conclusions: The expression level of DJ-1 in serum, umbilical cord blood and placenta tissue increased in preeclampsia
patients, suggesting that DJ-1 may take part in the pathophysiology process of preeclampsia.

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Keywords

DJ-1; preeclampsia; placenta; cord blood; oxidative stress

About this article
Title

Expression and significance of Parkinson disease protein 7 in placental, serum and umbilical cord blood in preeclampsia

Journal

Ginekologia Polska

Issue

Vol 91, No 12 (2020)

Article type

Research paper

Pages

764-768

Published online

2020-12-31

Page views

953

Article views/downloads

688

DOI

10.5603/GP.a2020.0131

Pubmed

33447996

Bibliographic record

Ginekol Pol 2020;91(12):764-768.

Keywords

DJ-1
preeclampsia
placenta
cord blood
oxidative stress

Authors

Tingting Yang
Jianying Yan
Qing Han
Qinjian Zhang
Qiuping Liao

References (17)
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