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Are serum Netrin-4 levels predictive of preeclampsia?
, 1, 1, 1, 2, 3, 1, 1
Affiliations- Department of Obstetrics and Gynecology, Dicle University Medical Faculty, Diyarbakır, Turkey
- Department of Biochemistry, Dicle University Medical Faculty, Diyarbakir, Turkey
- Department of Pediatrics, Dicle University Medical Faculty, Diyarbakir, Turkey
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Abstract
Objective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE). Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS). Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263). Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE.
Abstract
Objective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE). Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS). Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263). Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE.
Keywords
sFlt-1; Netrin-4; preeclampsia; anti-angiogenic effects
About this articleTitle
Are serum Netrin-4 levels predictive of preeclampsia?
Journal
Issue
Article type
Research paper
Pages
733-739
Published online
2020-10-12
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1082
Article views/downloads
948
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(12):733-739.
Keywords
sFlt-1
Netrin-4
preeclampsia
anti-angiogenic effects
Authors
Mehmet Sait İçen
Elif Ağaçayak
Fatih Mehmet Fındık
Senem Yaman Tunç
İbrahim Kaplan
İlhan Tan
Mehmet Sıddık Evsen
Talip Gül
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