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Vol 91, No 11 (2020)
Research paper
Published online: 2020-10-19
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Comparison of Anti-müllerian Hormone (AMH) and Hormonal Assays for Phenotypic Classification of Polycystic Ovary Syndrome

Ali Cenk Ozay1, Ozlen Emekcı Ozay1, Bulent Gulekli2
DOI: 10.5603/GP.a2020.0122
·
Pubmed: 33301159
·
Ginekol Pol 2020;91(11):661-667.
Affiliations
  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Near East University, Nicosia, Cyprus
  2. Dokuz Eylul University Faculty of Medicine Department of Obstetrics and Gynecology

open access

Vol 91, No 11 (2020)
ORIGINAL PAPERS Gynecology
Published online: 2020-10-19

Abstract

Objectives: The aim is to compare the hormonal status and anti-müllerian hormone (AMH) levels of patients who have different polycystic ovary syndrome (PCOS) phenotypes, polycystic ovarian morphology (PCOM) and healthy women. Material and methods: A total of 350 PCOS women, 71 women with PCOM and 79 healthy women with normal ovarian morphology (NOM) were observed. PCOS patients were divided into groups according to the phenotypes. Phenotype A- characterized by anovulation, hyperandrogenism and PCOM; phenotype B- defined as anovulation, hyperandrogenism; Phenotype C- identified as hyperandrogenism and PCOM; Phenotype D- outlined as anovulation and PCOM. AMH levels were compared for each group. Results: Among 350 PCOS patients the highest number belonged to phenotype A (n = 117, 33.4%). The rest were distrubuted as follows: phenotype B (n = 89, 25.4%), phenotype C (n = 72, 20.6%), phenotype D (n = 72, 20.6%). Phenotype A (9.17 ± 4.56) had the highest mean AMH levels in our study. Comparison of AMH levels showed a statistically significant difference between phenotypes A and D. There was a statistically significant difference on comparison of AMH between NOM, PCOM and all PCOS phenotypes. Conclusions: Phenotype A is the most serious form of PCOS and these patients has all three features which are hyperandrogenism, anovulation and ultrasound findings of polycystic ovary (PCO). AMH reflects the severity of PCOS and patients with Phenotype A have higher AMH levels.

Abstract

Objectives: The aim is to compare the hormonal status and anti-müllerian hormone (AMH) levels of patients who have different polycystic ovary syndrome (PCOS) phenotypes, polycystic ovarian morphology (PCOM) and healthy women. Material and methods: A total of 350 PCOS women, 71 women with PCOM and 79 healthy women with normal ovarian morphology (NOM) were observed. PCOS patients were divided into groups according to the phenotypes. Phenotype A- characterized by anovulation, hyperandrogenism and PCOM; phenotype B- defined as anovulation, hyperandrogenism; Phenotype C- identified as hyperandrogenism and PCOM; Phenotype D- outlined as anovulation and PCOM. AMH levels were compared for each group. Results: Among 350 PCOS patients the highest number belonged to phenotype A (n = 117, 33.4%). The rest were distrubuted as follows: phenotype B (n = 89, 25.4%), phenotype C (n = 72, 20.6%), phenotype D (n = 72, 20.6%). Phenotype A (9.17 ± 4.56) had the highest mean AMH levels in our study. Comparison of AMH levels showed a statistically significant difference between phenotypes A and D. There was a statistically significant difference on comparison of AMH between NOM, PCOM and all PCOS phenotypes. Conclusions: Phenotype A is the most serious form of PCOS and these patients has all three features which are hyperandrogenism, anovulation and ultrasound findings of polycystic ovary (PCO). AMH reflects the severity of PCOS and patients with Phenotype A have higher AMH levels.

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Keywords

polycystic ovary syndrome; phenotype; polycystic ovarian morphology; anti müllerian hormone; hyperandrogenism

About this article
Title

Comparison of Anti-müllerian Hormone (AMH) and Hormonal Assays for Phenotypic Classification of Polycystic Ovary Syndrome

Journal

Ginekologia Polska

Issue

Vol 91, No 11 (2020)

Article type

Research paper

Pages

661-667

Published online

2020-10-19

Page views

1814

Article views/downloads

1488

DOI

10.5603/GP.a2020.0122

Pubmed

33301159

Bibliographic record

Ginekol Pol 2020;91(11):661-667.

Keywords

polycystic ovary syndrome
phenotype
polycystic ovarian morphology
anti müllerian hormone
hyperandrogenism

Authors

Ali Cenk Ozay
Ozlen Emekcı Ozay
Bulent Gulekli

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