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Comparison of maternal characteristics, pregnancy course, and neonatal outcome in preterm births with and without prelabor rupture of membranes
, 1, 2, 1, 1, 1, 3, 1
Affiliations- 2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland
- Department of Obstetrics and Gynecology Didactics, Medical University of Warsaw, Warsaw, Poland
- Students’ Scientific Group affiliated to 2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland
open access
Abstract
Objectives: The aim of this study was to evaluate pregnancy outcome of patients with prelabor rupture of membranes
receiving expectant management and giving birth prematurely in comparison to preterm births of patients with intact
membranes.
Material and methods: It was a retrospective cohort study comparing maternal and neonatal outcome in two groups of
preterm births. The first group included 299 consecutive singleton preterm births complicated by prelabor rupture of membranes.
The second group consisted of 349 consecutive singleton preterm births without prelabor rupture of membranes.
Results: Patients without pPROM underwent Caesarean sections more often than women from the pPROM group (65.3%
vs 45.2%; p < 0.001). No statistically significant differences regarding the gestational age during delivery were identified.
Lower birth weight was detected in the group with no history of pPROM (p < 0.001).
No differences regarding early-onset sepsis were identified and higher percentage of late-onset infections was observed
in infants with no history of pPROM (8.9% vs 4.7%; p = 0.04). Pulmonary hypertension was more common in the infants
from the pPROM group (4% vs 1.4%; p = 0.049). Neonatal respiratory distress syndrome and respiratory failure were more
prevalent in cases of no pPROM history — 20% vs 12.7% (p = 0.02) and 40% vs 25.8% (p < 0.001), respectively.
Conclusions: Development of multiple complications in preterm neonates may be more associated with the management,
gestational age at birth, and birth weight than with the occurrence of preterm prelabor rupture of membranes.
Abstract
Objectives: The aim of this study was to evaluate pregnancy outcome of patients with prelabor rupture of membranes
receiving expectant management and giving birth prematurely in comparison to preterm births of patients with intact
membranes.
Material and methods: It was a retrospective cohort study comparing maternal and neonatal outcome in two groups of
preterm births. The first group included 299 consecutive singleton preterm births complicated by prelabor rupture of membranes.
The second group consisted of 349 consecutive singleton preterm births without prelabor rupture of membranes.
Results: Patients without pPROM underwent Caesarean sections more often than women from the pPROM group (65.3%
vs 45.2%; p < 0.001). No statistically significant differences regarding the gestational age during delivery were identified.
Lower birth weight was detected in the group with no history of pPROM (p < 0.001).
No differences regarding early-onset sepsis were identified and higher percentage of late-onset infections was observed
in infants with no history of pPROM (8.9% vs 4.7%; p = 0.04). Pulmonary hypertension was more common in the infants
from the pPROM group (4% vs 1.4%; p = 0.049). Neonatal respiratory distress syndrome and respiratory failure were more
prevalent in cases of no pPROM history — 20% vs 12.7% (p = 0.02) and 40% vs 25.8% (p < 0.001), respectively.
Conclusions: Development of multiple complications in preterm neonates may be more associated with the management,
gestational age at birth, and birth weight than with the occurrence of preterm prelabor rupture of membranes.
Keywords
pregnancy complications; pregnancy outcome; premature birth; preterm premature rupture of the membranes
About this articleTitle
Comparison of maternal characteristics, pregnancy course, and neonatal outcome in preterm births with and without prelabor rupture of membranes
Journal
Issue
Article type
Research paper
Pages
528-538
Published online
2020-09-30
Page views
846
Article views/downloads
882
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(9):528-538.
Keywords
pregnancy complications
pregnancy outcome
premature birth
preterm premature rupture of the membranes
Authors
Joanna Kacperczyk-Bartnik
Pawel Bartnik
Justyna Teliga-Czajkowska
Aneta Malinowska-Polubiec
Agnieszka Dobrowolska-Redo
Ewa Romejko-Wolniewicz
Malgorzata Bienko
Krzysztof Czajkowski
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