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Vol 91, No 7 (2020)
Research paper
Published online: 2020-06-10
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Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography — a Pilot Study

Marzanna Obrzut1, Bogdan Obrzut2, Marcin Zmuda3, Jakub Baran4, Marian Cholewa1, Richard Ehman5, Dorota Darmochwal-Kolarz2
DOI: 10.5603/GP.a2020.0067
·
Pubmed: 32542642
·
Ginekol Pol 2020;91(7):373-378.
Affiliations
  1. Department of Biophysics, Faculty of Mathematics and Natural Sciences, University of Rzeszow, Poland
  2. Department of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College, University of Rzeszow, Poland
  3. Department of Clinical Pathomorphology, Provincial Clinical Hospital No 2 Rzeszow, Poland
  4. Institute of Nuclear Physics Polish Academy of Sciences, Cracow, Poland
  5. Department of Radiology, Mayo Clinic, USA

open access

Vol 91, No 7 (2020)
ORIGINAL PAPERS Gynecology
Published online: 2020-06-10

Abstract

Objectives: To evaluate magnetic resonance elastography as a tool for characterizing uterine leimyomas.
Material and methods: At total of 12 women with symptomatic leiomyomas diagnosed in physical and ultrasound examinations
were enrolled in this pilot study. Before surgery, all patients underwent magnetic resonance elastography of
the uterus using a 1.5 T MR whole-body scanner (Optima, GE Healthcare, Milwaukee, WI, USA). Surgical specimens were
forwarded for histological examination. The findings were allocated into 3 categories depending on the percentage content
of connective tissue: below 15%, from 15 to 30% and more than 30%. The median stiffness of leiomyomas for each of the
group was calculated. The U-Mann Whitney test was used for statistical analysis.
Results: The stiffness of the leiomyomas ranged between 3.7–6.9 kPa (median value 4.9 kPa). The concentration of extracellular
components in the leiomyomas did not exceed 40%. An increasing trend of the stiffness with the growing percentage
of extracellular component was observed. Stiffness of the leiomyomas obtained by MRE varies depending on microscopic
composition.
Conclusions: The value of stiffness shows a trend of increasing with the percentage of extracellular component of the
leiomyoma. Further studies are required to assess the usefulness of MRE in diagnostics of uterine leiomyomas.

Abstract

Objectives: To evaluate magnetic resonance elastography as a tool for characterizing uterine leimyomas.
Material and methods: At total of 12 women with symptomatic leiomyomas diagnosed in physical and ultrasound examinations
were enrolled in this pilot study. Before surgery, all patients underwent magnetic resonance elastography of
the uterus using a 1.5 T MR whole-body scanner (Optima, GE Healthcare, Milwaukee, WI, USA). Surgical specimens were
forwarded for histological examination. The findings were allocated into 3 categories depending on the percentage content
of connective tissue: below 15%, from 15 to 30% and more than 30%. The median stiffness of leiomyomas for each of the
group was calculated. The U-Mann Whitney test was used for statistical analysis.
Results: The stiffness of the leiomyomas ranged between 3.7–6.9 kPa (median value 4.9 kPa). The concentration of extracellular
components in the leiomyomas did not exceed 40%. An increasing trend of the stiffness with the growing percentage
of extracellular component was observed. Stiffness of the leiomyomas obtained by MRE varies depending on microscopic
composition.
Conclusions: The value of stiffness shows a trend of increasing with the percentage of extracellular component of the
leiomyoma. Further studies are required to assess the usefulness of MRE in diagnostics of uterine leiomyomas.

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Keywords

leiomyoma; magnetic resonance elastography; histologic composition

About this article
Title

Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography — a Pilot Study

Journal

Ginekologia Polska

Issue

Vol 91, No 7 (2020)

Article type

Research paper

Pages

373-378

Published online

2020-06-10

Page views

882

Article views/downloads

818

DOI

10.5603/GP.a2020.0067

Pubmed

32542642

Bibliographic record

Ginekol Pol 2020;91(7):373-378.

Keywords

leiomyoma
magnetic resonance elastography
histologic composition

Authors

Marzanna Obrzut
Bogdan Obrzut
Marcin Zmuda
Jakub Baran
Marian Cholewa
Richard Ehman
Dorota Darmochwal-Kolarz

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