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The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting — a prospective study in a tertiary center
Affiliations- Department of Gynecology and Obstetrics, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey
- Department of Gynecology and Obstetrics, Dicle University,Diyarbakır, Turkey
- Department of Biochemistry, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey
- Department of Biochemistry, Yıldırım Beyazit University, Faculty of Medicine, Ankara, Turkey,
- Department of Gynecology and Obstetrics, Health Sciences University, Van Training and Research Hospital, Van, Turkey
- Department of Gynecology and Obstetrics, Bilim University, Florance Nightingale Hospital, İstanbul, Turkey
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Abstract
Objectives: We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketone
negative pregnant women with nausea and vomiting.
Material and methods: A total of 60 patients under the 14th week of pregnancy were included in this study, and they were
divided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negative
pregnant women with nausea, and vomiting.
Results: The native thiol, disulfide, and total thiol concentrations were measured using an automated method and compared
among the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index
1 = 100 × disulfide/native thiol); (Index 2 = 100 × disulfide/total thiol); (Index 3 = 100 × native thiol/total thiol). When
compared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide
(p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant.
Conclusions: Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This study
emphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approach
in treating the symptoms of women with ketone positive.
Abstract
Objectives: We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketone
negative pregnant women with nausea and vomiting.
Material and methods: A total of 60 patients under the 14th week of pregnancy were included in this study, and they were
divided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negative
pregnant women with nausea, and vomiting.
Results: The native thiol, disulfide, and total thiol concentrations were measured using an automated method and compared
among the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index
1 = 100 × disulfide/native thiol); (Index 2 = 100 × disulfide/total thiol); (Index 3 = 100 × native thiol/total thiol). When
compared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide
(p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant.
Conclusions: Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This study
emphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approach
in treating the symptoms of women with ketone positive.
Keywords
hyperemesis gravidarum; nausea and vomiting; thiol/disulfide homeostasis; oxidative stress
About this articleTitle
The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting — a prospective study in a tertiary center
Journal
Issue
Article type
Research paper
Pages
207-209
Published online
2020-03-31
Page views
1188
Article views/downloads
952
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(4):207-209.
Keywords
hyperemesis gravidarum
nausea and vomiting
thiol/disulfide homeostasis
oxidative stress
Authors
Serhat Ege
Nurullah Peker
Muhammed Hanifi Bademkıran
Ruşen Köçeroğlu
Özcan Erel
Selami Erdem
Çağdaş Özgökçe
Recep Yıldızhan
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