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Presence of human papilloma virus in Caucasian women living in the central Europe diagnosed with vulvar intraepithelial neoplasia
Affiliations- Medical University of Silesia, Katowice, Poland
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Abstract
Objectives: The role of human papilloma virus (HPV) in the development of cancerous states of female reproductive tract
has been widely debated. However, the information about presence of HPV in the Caucasian women living in the central
Europe diagnosed with vulvar intraepithelial neoplasia (VIN) is missing. So far, no recommendation was made to complete
HPV detection in time of vulvar biopsy or after the results of positive VIN are obtained. We aimed to assess the presence of
HPV in women with vulvar intraepithelial neoplasia diagnosed at the Department of Gynecology, Obstetrics and Oncological
Gynecology in Bytom, Poland.
Material and methods: The retrospective examination of 120 consecutive vulvar biopsies obtained from women with
persistent vulvar itching was done. Only patients with diagnosis of VIN were included in the further analysis. HPV DNA
was detected using HPV Linear Array Genotyping Test including 14 HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56,
58, 59, 66, 68).
Results: Out of 120 vulvar samples retrieved, 18 women were positive for VIN, including15 usual VIN (uVIN) and three differentiated
type (dVIN ). 10 samples were eligible for DNA detection. HPV DNA was found in two women with uVIN (HPV
16 and 51).
Conclusions: It is advisable to recommend HPV genotyping in women with VIN, regardless of their age and histologic type.
The incidence of HPV infection in Caucasian women from the central Europe with VIN should be further studied.
Abstract
Objectives: The role of human papilloma virus (HPV) in the development of cancerous states of female reproductive tract
has been widely debated. However, the information about presence of HPV in the Caucasian women living in the central
Europe diagnosed with vulvar intraepithelial neoplasia (VIN) is missing. So far, no recommendation was made to complete
HPV detection in time of vulvar biopsy or after the results of positive VIN are obtained. We aimed to assess the presence of
HPV in women with vulvar intraepithelial neoplasia diagnosed at the Department of Gynecology, Obstetrics and Oncological
Gynecology in Bytom, Poland.
Material and methods: The retrospective examination of 120 consecutive vulvar biopsies obtained from women with
persistent vulvar itching was done. Only patients with diagnosis of VIN were included in the further analysis. HPV DNA
was detected using HPV Linear Array Genotyping Test including 14 HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56,
58, 59, 66, 68).
Results: Out of 120 vulvar samples retrieved, 18 women were positive for VIN, including15 usual VIN (uVIN) and three differentiated
type (dVIN ). 10 samples were eligible for DNA detection. HPV DNA was found in two women with uVIN (HPV
16 and 51).
Conclusions: It is advisable to recommend HPV genotyping in women with VIN, regardless of their age and histologic type.
The incidence of HPV infection in Caucasian women from the central Europe with VIN should be further studied.
Keywords
vulvar intraepithelial neoplasia; human papilloma virus; vulvar itching
About this articleTitle
Presence of human papilloma virus in Caucasian women living in the central Europe diagnosed with vulvar intraepithelial neoplasia
Journal
Issue
Article type
Research paper
Pages
181-184
Published online
2020-03-30
Page views
1286
Article views/downloads
952
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(4):181-184.
Keywords
vulvar intraepithelial neoplasia
human papilloma virus
vulvar itching
Authors
Marta Robenek
Anita Olejek
Lukasz Witek
Aleksandra Augusciak-Duma
Bogna Drozdzowska
Iwona Gabriel
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