open access

Vol 89, No 12 (2018)
REVIEW PAPERS Gynecology
Published online: 2018-12-28
Get Citation

Current treatment options for advanced choriocarcinoma on the basis of own case and review of the literature

Patrycja Wreczycka-Cegielny, Tomasz Cegielny, Marcin Oplawski, Wlodzimierz Sawicki, Zbigniew Kojs
DOI: 10.5603/GP.a2018.0120
·
Pubmed: 30618041
·
Ginekol Pol 2018;89(12):711-715.

open access

Vol 89, No 12 (2018)
REVIEW PAPERS Gynecology
Published online: 2018-12-28

Abstract

Choriocarcinoma is one of rare neoplasms of female reproductive organs. In the last decade only a few cases of this disease have been registered in Poland. The paper presents the current principles of diagnosis and treatment options for this rare disease based on the authors’ clinical experience (description of the case) and literature review. This paper provides basic information on epidemiology, FIGO classification, and also discusses the chemotherapy regimens used in the medical treatment of choriocarcinoma. Surgical options were also considered.

A thematic review of the most important papers published in international journals in recent years has also been made.

Abstract

Choriocarcinoma is one of rare neoplasms of female reproductive organs. In the last decade only a few cases of this disease have been registered in Poland. The paper presents the current principles of diagnosis and treatment options for this rare disease based on the authors’ clinical experience (description of the case) and literature review. This paper provides basic information on epidemiology, FIGO classification, and also discusses the chemotherapy regimens used in the medical treatment of choriocarcinoma. Surgical options were also considered.

A thematic review of the most important papers published in international journals in recent years has also been made.

Get Citation

Keywords

choriocarcinoma; trophoblast tumour; gestational trophoblastic disease

About this article
Title

Current treatment options for advanced choriocarcinoma on the basis of own case and review of the literature

Journal

Ginekologia Polska

Issue

Vol 89, No 12 (2018)

Pages

711-715

Published online

2018-12-28

DOI

10.5603/GP.a2018.0120

Pubmed

30618041

Bibliographic record

Ginekol Pol 2018;89(12):711-715.

Keywords

choriocarcinoma
trophoblast tumour
gestational trophoblastic disease

Authors

Patrycja Wreczycka-Cegielny
Tomasz Cegielny
Marcin Oplawski
Wlodzimierz Sawicki
Zbigniew Kojs

References (24)
  1. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010; 203(6): 531–539.
  2. Goldstein DP, Berkowitz RS. Current management of gestational trophoblastic neoplasia. Hematol Oncol Clin North Am. 2012; 26(1): 111–131.
  3. Tarney CM, Tian C, Craig ER, et al. Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. Int J Gynecol Cancer. 2018; 28(2): 338–345.
  4. Soper JT. Gestational trophoblastic disease. Obstet Gynecol. 2006; 108(1): 176–187.
  5. Seckl M, Sebire N, Berkowitz R. Gestational trophoblastic disease. The Lancet. 2010; 376(9742): 717–729.
  6. Lin LH, Fushida K, Hase EA, et al. Gestational Tubal Choriocarcinoma Presenting as a Pregnancy of Unknown Location following Ovarian Induction. Case Rep Obstet Gynecol. 2018; 2018: 4705192.
  7. Han V, Kaye S. A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. J Obstet Gynaecol Can. 2018; 40(3): 351–353.
  8. Liu S, Fan C, Feng F, et al. Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. Cancer Biol Med. 2017; 14(2): 191–193.
  9. Ngan H, Bender H, Benedet JL, et al. Gestational trophoblastic neoplasia, FIGO 2000 staging and classification. International Journal of Gynecology & Obstetrics. 2004; 83: 175–177.
  10. Wojciechowska U, Didkowska J. Zachorowania i zgony na nowotwory złośliwe w Polsce. KRN, Centrum Onkologii, Instytut Marie Skłodowskiej-Curie, www.onkologia.org.pl. 2014.
  11. FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee. Int J Gynaecol Obstet. 2002; 77(3): 285–287.
  12. Suzuka K. Adjuvant hysterectomy in low-risk gestational trophoblastic disease. Obstetrics & Gynecology. 2001; 97(3): 431–434.
  13. Mangili G, Lorusso D, Brown J, et al. Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer. 2014; 24(9 Suppl 3): S109–S116.
  14. Soper JT. Role of surgery and radiation therapy in the management of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol. 2003; 17(6): 943–957.
  15. Gavanier D, Leport H, Massardier J, et al. Gestational trophoblastic neoplasia with brain metastasis at initial presentation: a retrospective study. Int J Clin Oncol. 2018 [Epub ahead of print].
  16. Frost AS, Sherman JH, Rezaei K, et al. Choriocarcinoma with brain, lung and vaginal metastases successfully treated without brain radiation or intrathecal chemotherapy: A case report. Gynecol Oncol Rep. 2017; 20: 97–99.
  17. Hanna RK, Soper JT. The role of surgery and radiation therapy in the management of gestational trophoblastic disease. Oncologist. 2010; 15(6): 593–600.
  18. Vaid N, Kaur C, Vidya S, et al. A Case Report on Radiotherapy in Choriocarcinoma: A Life Saving Procedure. Asia-Oceania Journal of Obstetrics and Gynaecology. 2010; 20(3): 245–247.
  19. Gestational Trophoblastic Disease. 2012.
  20. Lawrie T, Alazzam M, Tidy J, et al. First-line chemotherapy in low-risk gestational trophoblastic neoplasia. Cochrane Database of Systematic Reviews. 2016.
  21. Deng L, Zhang J, Wu T, et al. Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour. Cochrane Database of Systematic Reviews. 2013.
  22. Dhanushkodi M, Ganesan T, Sagar TG. Refractory Choriocarcinoma: Complete Response With Oral Etoposide. J Glob Oncol. 2017; 3(5): 678–679.
  23. Wang Q, Fu J, Hu L, et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database of Systematic Reviews. 2017.
  24. Braga A, Campos V, Filho JR, et al. Is chemotherapy always necessary for patients with nonmetastatic gestational trophoblastic neoplasia with histopathological diagnosis of choriocarcinoma? Gynecol Oncol. 2018; 148(2): 239–246.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl