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Vol 89, No 12 (2018)
Research paper
Published online: 2018-12-28
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An investigation of the effect of placental growth factor on intrapartum fetal compromise prediction in terminduced high risk pregnancies

Mehmet Şükrü Budak1, Gülten Toprak2, Sedat Akgöl1, Mehmet Obut1, Cemil Oglak1, Ihsan Baglı1, Ilker Kahramanoglu1
DOI: 10.5603/GP.a2018.0118
·
Pubmed: 30618039
·
Ginekol Pol 2018;89(12):700-704.
Affiliations
  1. Department of Obstetrics and Gynecology, Health Sciences University Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakır, Turkey
  2. Department of Biochemistry, Faculty of Medicene, Dicle University, Diyarbakır, Turkey

open access

Vol 89, No 12 (2018)
ORIGINAL PAPERS Obstetrics
Published online: 2018-12-28

Abstract

Objectives: To date, there is no available test to predict the risk of intrapartum fetal compromise (IFC) during labor, either starting spontaneously or induced due to obstetrics indications. The aim of this study was to examine the effectiveness of placental growth factor (PIGF) in identifying cases that develop intrapartum fetal compromise (IFC) in term high-risk pregnancies induced for labor.
Material and methods: This prospective cross-sectional study was conducted on 40 IFC+ cases and 40 IFC- cases with
high-risk term pregnancy and labor induction started in the Health Sciences University Gazi Yaşargil Training and Research Hospital, between January 2018 and April 2018. Comparisons were made between the groups in respect of placental growth factor (PIGF) levels, and obstetric and neonatal outcomes.
Results: The PIGF level was found to be statistically significantly lower in the IFC+ cases compared to the IFC- cases. For a PIGF cutoff value of 32 pg/mL for the prediction of IFC+ cases, sensitivity was 74.4%, specificity 73.2%, NPV 75% and PPV 72.5%, with a statistically significant difference determined between the groups. The IFC+ development risk increased 7.91-fold in patients with PIGF ≤ 32 pg/mL.
Conclusions: The PIGF levels in cases of IFC+ high risk pregnancies were found to be statistically significantly lower than those of IFC- cases. However, further, large-scale randomized controlled research is necessary to demonstrate this relationship better.

Abstract

Objectives: To date, there is no available test to predict the risk of intrapartum fetal compromise (IFC) during labor, either starting spontaneously or induced due to obstetrics indications. The aim of this study was to examine the effectiveness of placental growth factor (PIGF) in identifying cases that develop intrapartum fetal compromise (IFC) in term high-risk pregnancies induced for labor.
Material and methods: This prospective cross-sectional study was conducted on 40 IFC+ cases and 40 IFC- cases with
high-risk term pregnancy and labor induction started in the Health Sciences University Gazi Yaşargil Training and Research Hospital, between January 2018 and April 2018. Comparisons were made between the groups in respect of placental growth factor (PIGF) levels, and obstetric and neonatal outcomes.
Results: The PIGF level was found to be statistically significantly lower in the IFC+ cases compared to the IFC- cases. For a PIGF cutoff value of 32 pg/mL for the prediction of IFC+ cases, sensitivity was 74.4%, specificity 73.2%, NPV 75% and PPV 72.5%, with a statistically significant difference determined between the groups. The IFC+ development risk increased 7.91-fold in patients with PIGF ≤ 32 pg/mL.
Conclusions: The PIGF levels in cases of IFC+ high risk pregnancies were found to be statistically significantly lower than those of IFC- cases. However, further, large-scale randomized controlled research is necessary to demonstrate this relationship better.

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Keywords

term high-risk pregnancy; labor induction; placental growth factor; intrapartum fetal compromise

About this article
Title

An investigation of the effect of placental growth factor on intrapartum fetal compromise prediction in terminduced high risk pregnancies

Journal

Ginekologia Polska

Issue

Vol 89, No 12 (2018)

Article type

Research paper

Pages

700-704

Published online

2018-12-28

Page views

1547

Article views/downloads

887

DOI

10.5603/GP.a2018.0118

Pubmed

30618039

Bibliographic record

Ginekol Pol 2018;89(12):700-704.

Keywords

term high-risk pregnancy
labor induction
placental growth factor
intrapartum fetal compromise

Authors

Mehmet Şükrü Budak
Gülten Toprak
Sedat Akgöl
Mehmet Obut
Cemil Oglak
Ihsan Baglı
Ilker Kahramanoglu

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