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The preoperative serum CA125 can predict the lymph node metastasis in endometrioid-type endometrial cancer
Affiliations- Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Department of Gynecology, Ankara, Turkey
- Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Department of Gynecologic Oncology, Kecioren, Ankara, Turkey
open access
Abstract
Objectives: To evaluate the predictive value of preoperative CA125 in extra-uterine disease and its association with poor
prognostic factors in endometrioid-type endometrial cancer (EC).
Material and methods: A total of 423 patients with pathologically proven endometrioid-type EC were included in the
study. The association between preoperative CA125 level and surgical–pathological factors was evaluated. The conventional cut-off value was defined as 35 IU/mL.
Results: A high CA125 level ( > 35 IU/mL) was significantly associated with all of the studied poor prognostic factors,
except grade. The risk of lymph node metastasis (LNM) increased from 15.9% to 45.7% when CA125 level was > 35 IU/mL (p < 0.05). The optimal cut-off value for the prediction of LNM in patients aged > 50 years was determined to be 16 IU/mL (sensitivity, specificity, positive predictive value, and negative predictive value were 71%, 60%, 35%, and 87%, respectively.)
Conclusions: Preoperative CA125 level was significantly related with the extent of the disease and LNM. The age-dependent cut-off level of CA125 can improve the prediction of LNM in endometrioid-type EC. For older patients, CA125 level of > 16 IU/ml could be used to predict LNM. However, further studies are needed to evaluate the appropriate cut-off level of CA125 for younger patients.
Abstract
Objectives: To evaluate the predictive value of preoperative CA125 in extra-uterine disease and its association with poor
prognostic factors in endometrioid-type endometrial cancer (EC).
Material and methods: A total of 423 patients with pathologically proven endometrioid-type EC were included in the
study. The association between preoperative CA125 level and surgical–pathological factors was evaluated. The conventional cut-off value was defined as 35 IU/mL.
Results: A high CA125 level ( > 35 IU/mL) was significantly associated with all of the studied poor prognostic factors,
except grade. The risk of lymph node metastasis (LNM) increased from 15.9% to 45.7% when CA125 level was > 35 IU/mL (p < 0.05). The optimal cut-off value for the prediction of LNM in patients aged > 50 years was determined to be 16 IU/mL (sensitivity, specificity, positive predictive value, and negative predictive value were 71%, 60%, 35%, and 87%, respectively.)
Conclusions: Preoperative CA125 level was significantly related with the extent of the disease and LNM. The age-dependent cut-off level of CA125 can improve the prediction of LNM in endometrioid-type EC. For older patients, CA125 level of > 16 IU/ml could be used to predict LNM. However, further studies are needed to evaluate the appropriate cut-off level of CA125 for younger patients.
Keywords
preoperative CA125; endometrial cancer; lymph node metastases; poor prognostic factors
About this articleTitle
The preoperative serum CA125 can predict the lymph node metastasis in endometrioid-type endometrial cancer
Journal
Issue
Article type
Research paper
Pages
599-606
Published online
2018-11-30
Page views
2283
Article views/downloads
1382
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(11):599-606.
Keywords
preoperative CA125
endometrial cancer
lymph node metastases
poor prognostic factors
Authors
Mehmet Ünsal
Gunsu Kimyon Comert
Alper Karalok
Derman Basaran
Osman Turkmen
Gokhan Boyraz
Tolga Tasci
Sevgi Koc
Nurettin Boran
Gokhan Tulunay
Taner Turan
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