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Isolated pulmonary metastases in patients with cervical cancer and the factors affecting survival after recurrence
Affiliations- Mersin State Hospital, Department of Obstetrics and Gynecology, Mersin, Turkey
- Tepecik Education and Research Hospital, Department of Obstetrics and Gynecology, İzmir, Turkey
- Muğla Sıtkı Koçman University, Department of Obstetrics and Gynecology, Muğla, Turkey
- Sadi Konuk Education and Research Hospital, Department of Gynecological Oncology, İstanbul, Turkey
open access
Abstract
Objectives: The aim of this study was to assess the treatment options and survival of uterine cervical cancer (UCC) patients who develop isolated pulmonary metastases (IPM) and to establish risk factors for IPM.
Material and Methods: Data from patients diagnosed with UCC between June 1991 and January 2017 at the Gynecological Oncology Department, Tepecik Training and Research Hospital, were investigated. In total, 43 cases with IPM were evaluated retrospectively. Additionally, 172 control patients diagnosed with UCC without recurrence were matched according to the International Federation of Gynecology and Obstetrics (FIGO) 2009 stage when the tumor was diagnosed. They wereselected using a dependent random sampling method.
Results: Of the 890 patients with UCC, 43 (4.8%) had IPM. The presence of lymphovascular space invasion (LVSI) and
a mid-corpuscular volume (MCV) < 80 fL were statistically significant prognostic factors for IPM development in UCC patientsaccording to univariate regression analyses, and the presence of LVSI, a hemoglobin level < 12 g/dL, and an MCV < 80 fLwere statistically significant according to the multivariate regression analyses. We were unable to assess the role of lymph node status (involvement or reactive) as a prognostic factor in the development of IPM, because only seven patients (16.2%) in the case group underwent lymph node dissection.
Conclusions: IPM typically develops within the first 3 years after the diagnosis of UCC, and survival is generally poor. An
MCV < 80 fL and the presence of LVSI are significant risk factors for IPM development.
Abstract
Objectives: The aim of this study was to assess the treatment options and survival of uterine cervical cancer (UCC) patients who develop isolated pulmonary metastases (IPM) and to establish risk factors for IPM.
Material and Methods: Data from patients diagnosed with UCC between June 1991 and January 2017 at the Gynecological Oncology Department, Tepecik Training and Research Hospital, were investigated. In total, 43 cases with IPM were evaluated retrospectively. Additionally, 172 control patients diagnosed with UCC without recurrence were matched according to the International Federation of Gynecology and Obstetrics (FIGO) 2009 stage when the tumor was diagnosed. They wereselected using a dependent random sampling method.
Results: Of the 890 patients with UCC, 43 (4.8%) had IPM. The presence of lymphovascular space invasion (LVSI) and
a mid-corpuscular volume (MCV) < 80 fL were statistically significant prognostic factors for IPM development in UCC patientsaccording to univariate regression analyses, and the presence of LVSI, a hemoglobin level < 12 g/dL, and an MCV < 80 fLwere statistically significant according to the multivariate regression analyses. We were unable to assess the role of lymph node status (involvement or reactive) as a prognostic factor in the development of IPM, because only seven patients (16.2%) in the case group underwent lymph node dissection.
Conclusions: IPM typically develops within the first 3 years after the diagnosis of UCC, and survival is generally poor. An
MCV < 80 fL and the presence of LVSI are significant risk factors for IPM development.
Keywords
uterine cervical cancer; isolated pulmonary metastases
About this articleTitle
Isolated pulmonary metastases in patients with cervical cancer and the factors affecting survival after recurrence
Journal
Issue
Article type
Research paper
Pages
593-598
Published online
2018-11-30
Page views
2024
Article views/downloads
1154
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(11):593-598.
Keywords
uterine cervical cancer
isolated pulmonary metastases
Authors
Varol Gülseren
Mustafa Kocaer
Özgü Güngördük
İsa Aykut Özdemir
Ceren Gölbaşı
Adnan Budak
Mehmet Gökçü
Muzaffer Sancı
Kemal Güngördük
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