open access

Vol 89, No 11 (2018)
ORIGINAL PAPERS Gynecology
Published online: 2018-11-30
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Isolated pulmonary metastases in patients with cervical cancer and the factors affecting survival after recurrence

Varol Gülseren, Mustafa Kocaer, Özgü Güngördük, İsa Aykut Özdemir, Ceren Gölbaşı, Adnan Budak, Mehmet Gökçü, Muzaffer Sancı, Kemal Güngördük
DOI: 10.5603/GP.a2018.0102
·
Pubmed: 30508210
·
Ginekol Pol 2018;89(11):593-598.

open access

Vol 89, No 11 (2018)
ORIGINAL PAPERS Gynecology
Published online: 2018-11-30

Abstract

Objectives: The aim of this study was to assess the treatment options and survival of uterine cervical cancer (UCC) patients who develop isolated pulmonary metastases (IPM) and to establish risk factors for IPM.
Material and Methods: Data from patients diagnosed with UCC between June 1991 and January 2017 at the Gynecological Oncology Department, Tepecik Training and Research Hospital, were investigated. In total, 43 cases with IPM were evaluated retrospectively. Additionally, 172 control patients diagnosed with UCC without recurrence were matched according to the International Federation of Gynecology and Obstetrics (FIGO) 2009 stage when the tumor was diagnosed. They wereselected using a dependent random sampling method.
Results: Of the 890 patients with UCC, 43 (4.8%) had IPM. The presence of lymphovascular space invasion (LVSI) and
a mid-corpuscular volume (MCV) < 80 fL were statistically significant prognostic factors for IPM development in UCC patientsaccording to univariate regression analyses, and the presence of LVSI, a hemoglobin level < 12 g/dL, and an MCV < 80 fLwere statistically significant according to the multivariate regression analyses. We were unable to assess the role of lymph node status (involvement or reactive) as a prognostic factor in the development of IPM, because only seven patients (16.2%) in the case group underwent lymph node dissection.
Conclusions: IPM typically develops within the first 3 years after the diagnosis of UCC, and survival is generally poor. An
MCV < 80 fL and the presence of LVSI are significant risk factors for IPM development.

Abstract

Objectives: The aim of this study was to assess the treatment options and survival of uterine cervical cancer (UCC) patients who develop isolated pulmonary metastases (IPM) and to establish risk factors for IPM.
Material and Methods: Data from patients diagnosed with UCC between June 1991 and January 2017 at the Gynecological Oncology Department, Tepecik Training and Research Hospital, were investigated. In total, 43 cases with IPM were evaluated retrospectively. Additionally, 172 control patients diagnosed with UCC without recurrence were matched according to the International Federation of Gynecology and Obstetrics (FIGO) 2009 stage when the tumor was diagnosed. They wereselected using a dependent random sampling method.
Results: Of the 890 patients with UCC, 43 (4.8%) had IPM. The presence of lymphovascular space invasion (LVSI) and
a mid-corpuscular volume (MCV) < 80 fL were statistically significant prognostic factors for IPM development in UCC patientsaccording to univariate regression analyses, and the presence of LVSI, a hemoglobin level < 12 g/dL, and an MCV < 80 fLwere statistically significant according to the multivariate regression analyses. We were unable to assess the role of lymph node status (involvement or reactive) as a prognostic factor in the development of IPM, because only seven patients (16.2%) in the case group underwent lymph node dissection.
Conclusions: IPM typically develops within the first 3 years after the diagnosis of UCC, and survival is generally poor. An
MCV < 80 fL and the presence of LVSI are significant risk factors for IPM development.

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Keywords

uterine cervical cancer; isolated pulmonary metastases

About this article
Title

Isolated pulmonary metastases in patients with cervical cancer and the factors affecting survival after recurrence

Journal

Ginekologia Polska

Issue

Vol 89, No 11 (2018)

Pages

593-598

Published online

2018-11-30

DOI

10.5603/GP.a2018.0102

Pubmed

30508210

Bibliographic record

Ginekol Pol 2018;89(11):593-598.

Keywords

uterine cervical cancer
isolated pulmonary metastases

Authors

Varol Gülseren
Mustafa Kocaer
Özgü Güngördük
İsa Aykut Özdemir
Ceren Gölbaşı
Adnan Budak
Mehmet Gökçü
Muzaffer Sancı
Kemal Güngördük

References (13)
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