open access

Vol 89, No 9 (2018)
REVIEW PAPERS Obstetrics
Published online: 2018-09-28
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The role of visfatin in pathogenesis of gestational diabetes (GDM)

Sandra Radzicka, Marek Pietryga, Rafal Iciek, Jacek Brązert
DOI: 10.5603/GP.a2018.0088
·
Pubmed: 30318580
·
Ginekol Pol 2018;89(9):518-521.

open access

Vol 89, No 9 (2018)
REVIEW PAPERS Obstetrics
Published online: 2018-09-28

Abstract

Gestational diabetes (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. Two major metabolic disorders: insulin resistance and β-cells dysfunction, play currently major role in pathogenesis of GDM. Adipose tissue is an organ involved in production of adipokines, which have various influence on metabolism of glucose and lipids. Visfatin is an adipokine mainly produced and secreted by the fat tissue. It exerts an insulin-like effect by binding to the insulin receptor-1 and have hypoglycemic effect. Visfatin appears to be an important factor in the pathophysiology of GDM. The aim of this article is to review the literature concerning the relationship between the adipokine mentioned above and GDM, and to clarify its role in the pathophysiology of GDM.

Abstract

Gestational diabetes (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. Two major metabolic disorders: insulin resistance and β-cells dysfunction, play currently major role in pathogenesis of GDM. Adipose tissue is an organ involved in production of adipokines, which have various influence on metabolism of glucose and lipids. Visfatin is an adipokine mainly produced and secreted by the fat tissue. It exerts an insulin-like effect by binding to the insulin receptor-1 and have hypoglycemic effect. Visfatin appears to be an important factor in the pathophysiology of GDM. The aim of this article is to review the literature concerning the relationship between the adipokine mentioned above and GDM, and to clarify its role in the pathophysiology of GDM.

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Keywords

visfatin, NAMPT, gestational diabetes mellitus, GDM, adipocytokines

About this article
Title

The role of visfatin in pathogenesis of gestational diabetes (GDM)

Journal

Ginekologia Polska

Issue

Vol 89, No 9 (2018)

Pages

518-521

Published online

2018-09-28

DOI

10.5603/GP.a2018.0088

Pubmed

30318580

Bibliographic record

Ginekol Pol 2018;89(9):518-521.

Keywords

visfatin
NAMPT
gestational diabetes mellitus
GDM
adipocytokines

Authors

Sandra Radzicka
Marek Pietryga
Rafal Iciek
Jacek Brązert

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