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Adipokines and C-peptide in overweight and obese pregnant women
Affiliations- Klinika Położnictwa i Perinatologii Samodzielnego Publicznego Szpitala Klinicznego nr 4 w Lublinie
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Abstract
Objectives: The aim of the study was to evaluate the levels of adipokines such as adiponectin, resistin, leptin as well as C-peptide in overweight and obese pregnant women.
Material and methods: The adipokines and C-peptide concentrations were measured in the group of 38 overweight/obese pregnant women (BMI > 25 kg/m2) and in 42 pregnant women of normal weight (BMI < 25 kg/m2) with ELISA tests between 24th and 34th weeks of gestation.
Results: The overweight/obese women compared to lean ones were characterized by significantly higher concentrations of leptin (43.44 ± 31.41 vs. 21.29 ± 12.67 ng/mL, p = 0.0001) and C-peptide (2.77 ± 1.88 vs. 2.25 ± 1.42 ng/mL, p = 0.034). There were no significant differences between groups in resistin (17.39 ± 7.59 vs. 15.76 ± 6.64 ng/mL, NS) and adiponectin (6.93 ± 3.52 vs. 8.07 ± 6.53 μg/mL, NS) levels. In the overweight/obese patients, no relationships between the adipokines, C-peptide and CRP concentrations were found. BMI was negatively correlated with the resistin levels (R = –0.406, p = 0.011). The significant correlation between leptin and C-peptide concentrations was observed in the study group (R = 0.517, p = 0.012). In the control group, the negative correlation between adiponectin concentrations and BMI was shown (R = –0.446, p = 0.003).
Conclusions: The higher levels of leptin in the overweight and obese pregnant women seem to reflect the leptin resistance condition and the higher levels of C-peptide in this group is suggestive for hyperinsulinemia. The positive correlation between C-peptide and leptin levels but not with resistin and adiponectin might confirm the role of leptin in the hyperinsulinemia development in overweight and obesity during pregnancy.
Abstract
Objectives: The aim of the study was to evaluate the levels of adipokines such as adiponectin, resistin, leptin as well as C-peptide in overweight and obese pregnant women.
Material and methods: The adipokines and C-peptide concentrations were measured in the group of 38 overweight/obese pregnant women (BMI > 25 kg/m2) and in 42 pregnant women of normal weight (BMI < 25 kg/m2) with ELISA tests between 24th and 34th weeks of gestation.
Results: The overweight/obese women compared to lean ones were characterized by significantly higher concentrations of leptin (43.44 ± 31.41 vs. 21.29 ± 12.67 ng/mL, p = 0.0001) and C-peptide (2.77 ± 1.88 vs. 2.25 ± 1.42 ng/mL, p = 0.034). There were no significant differences between groups in resistin (17.39 ± 7.59 vs. 15.76 ± 6.64 ng/mL, NS) and adiponectin (6.93 ± 3.52 vs. 8.07 ± 6.53 μg/mL, NS) levels. In the overweight/obese patients, no relationships between the adipokines, C-peptide and CRP concentrations were found. BMI was negatively correlated with the resistin levels (R = –0.406, p = 0.011). The significant correlation between leptin and C-peptide concentrations was observed in the study group (R = 0.517, p = 0.012). In the control group, the negative correlation between adiponectin concentrations and BMI was shown (R = –0.446, p = 0.003).
Conclusions: The higher levels of leptin in the overweight and obese pregnant women seem to reflect the leptin resistance condition and the higher levels of C-peptide in this group is suggestive for hyperinsulinemia. The positive correlation between C-peptide and leptin levels but not with resistin and adiponectin might confirm the role of leptin in the hyperinsulinemia development in overweight and obesity during pregnancy.
Keywords
adipocytokines, C-peptide, obesity, pregnancy
About this articleTitle
Adipokines and C-peptide in overweight and obese pregnant women
Journal
Issue
Article type
Research paper
Pages
443-449
Published online
2018-08-31
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1391
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1070
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(8):443-449.
Keywords
adipocytokines
C-peptide
obesity
pregnancy
Authors
Elżbieta Poniedziałek-Czajkowska
Radzisław Mierzyński
Magdalena Słodzińska
Dominik Dłuski
Bożena Leszczyńska-Gorzelak
References (35)- Australian Bureau of Statistics. Australian social trends 2007: Overweight and obesity. Cat. no. 4102.0. Canberra: ABS. ; 2007.
- Kim SS, Zhu Y, Grantz KL, et al. Obstetric and Neonatal Risks Among Obese Women Without Chronic Disease. Obstet Gynecol. 2016; 128(1): 104–112.
- Lau C, Rogers JM, Desai M, et al. Fetal programming of adult disease: implications for prenatal care. Obstet Gynecol. 2011; 117(4): 978–985.
- Briana DD, Malamitsi-Puchner A. The role of adipocytokines in fetal growth. Ann N Y Acad Sci. 2010; 1205: 82–87.
- Antuna-Puente B, Feve B, Fellahi S, et al. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab. 2008; 34(1): 2–11.
- Lappas M, Yee K, Permezel M, et al. Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. J Endocrinol. 2005; 186(3): 457–465.
- Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 62: 413–437.
- Song Y, Gao J, Qu Y, et al. Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia. Clin Chim Acta. 2016; 458: 133–137.
- Henson MC, Castracane VD. Leptin in pregnancy: an update. Biol Reprod. 2006; 74(2): 218–229.
- Balland E, Cowley MA. New insights in leptin resistance mechanisms in mice. Front Neuroendocrinol. 2015; 39: 59–65.
- Ladyman SR, Grattan DR. Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology. 2005; 146(9): 3868–3874.
- Wen F, Zhang H, Bao C, et al. Resistin Increases Ectopic Deposition of Lipids Through miR-696 in C2C12 Cells. Biochem Genet. 2015; 53(4-6): 63–71.
- Codoñer-Franch P, Alonso-Iglesias E. Resistin: insulin resistance to malignancy. Clin Chim Acta. 2015; 438: 46–54.
- Rajala MW, Qi Y, Patel HR, et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes. 2004; 53(7): 1671–1679.
- Ayeser T, Basak M, Arslan K, et al. Investigating the correlation of the number of diagnostic criteria to serum adiponectin, leptin, resistin, TNF-alpha, EGFR levels and abdominal adipose tissue. Diabetes Metab Syndr. 2016; 10(2 Suppl 1): S165–S169.
- Yura S, Sagawa N, Itoh H, et al. Resistin is expressed in the human placenta. J Clin Endocrinol Metab. 2003; 88(3): 1394–1397.
- Zavalza-Gómez AB, Anaya-Prado R, Rincón-Sánchez AR, et al. Adipokines and insulin resistance during pregnancy. Diabetes Res Clin Pract. 2008; 80(1): 8–15.
- Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A. 2001; 98(4): 2005–2010.
- Ouchi N, Kihara S, Funahashi T, et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation. 2003; 107(5): 671–674.
- Catalano PM, Hoegh M, Minium J, et al. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia. 2006; 49(7): 1677–1685.
- Brandenburg D. History and diagnostic significance of C-peptide. Exp Diabetes Res. 2008; 2008: 576862.
- Ozias MK, Li S, Hull HR, et al. Relationship of circulating adipokines to body composition in pregnant women. Adipocyte. 2015; 4(1): 44–49.
- O'Sullivan AJ, Kriketos AD, Martin A, et al. Serum adiponectin levels in normal and hypertensive pregnancy. Hypertens Pregnancy. 2006; 25(3): 193–203.
- Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001; 7(8): 941–946.
- Ritterath C, Rad NT, Siegmund T, et al. Adiponectin during pregnancy: correlation with fat metabolism, but not with carbohydrate metabolism. Arch Gynecol Obstet. 2010; 281(1): 91–96.
- McLachlan KA, O'Neal D, Jenkins A, et al. Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev. 2006; 22(2): 131–138.
- Hendler I, Blackwell SC, Mehta SH, et al. The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia. Am J Obstet Gynecol. 2005; 193(3 Pt 2): 979–983.
- Cortelazzi D, Corbetta S, Ronzoni S, et al. Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin Endocrinol (Oxf). 2007; 66(3): 447–453.
- Mazaki-Tovi S, Kanety H, Pariente C, et al. Maternal serum adiponectin levels during human pregnancy. J Perinatol. 2007; 27(2): 77–81.
- Verhaeghe J, van Bree R, Lambin S, et al. Adipokine profile and C-reactive protein in pregnancy: effects of glucose challenge response versus body mass index. J Soc Gynecol Investig. 2005; 12(5): 330–334.
- Qiu C, Williams MA, Vadachkoria S, et al. Increased maternal plasma leptin in early pregnancy and risk of gestational diabetes mellitus. Obstet Gynecol. 2004; 103(3): 519–525.
- Misra VK, Trudeau S. The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy. Obesity (Silver Spring). 2011; 19(2): 416–421.
- Megia A, Vendrell J, Gutierrez C, et al. Insulin sensitivity and resistin levels in gestational diabetes mellitus and after parturition. Eur J Endocrinol. 2008; 158(2): 173–178.
- Das UN, Das UN. Obesity, metabolic syndrome X, and inflammation. Nutrition. 2002; 18(5): 430–432.
- Johansson J, Ekberg K, Shafqat J, et al. Molecular effects of proinsulin C-peptide. Biochemical and Biophysical Research Communications. 2002; 295(5): 1035–1040.
