open access

Vol 89, No 8 (2018)
Research paper
Published online: 2018-08-31
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The role of osteopontin in the pathogenesis of placenta percreta

Alev Özer1, Aslı Yaylalı, Sezen Koçarslan
·
Pubmed: 30215463
·
Ginekol Pol 2018;89(8):438-442.
Affiliations
  1. Kahramanmaras Sutcu Imam University, 46000 Kahramanmaras, Türkiye

open access

Vol 89, No 8 (2018)
ORIGINAL PAPERS Obstetrics
Published online: 2018-08-31

Abstract

Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by compar­ing osteopontin expression in normal placentas and placenta percreta tissues.

Material and methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.

Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteo­pontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).

Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.

Abstract

Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by compar­ing osteopontin expression in normal placentas and placenta percreta tissues.

Material and methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.

Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteo­pontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).

Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.

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Keywords

immunohistochemistry; osteopontin; placenta percrata

About this article
Title

The role of osteopontin in the pathogenesis of placenta percreta

Journal

Ginekologia Polska

Issue

Vol 89, No 8 (2018)

Article type

Research paper

Pages

438-442

Published online

2018-08-31

Page views

1867

Article views/downloads

1086

DOI

10.5603/GP.a2018.0075

Pubmed

30215463

Bibliographic record

Ginekol Pol 2018;89(8):438-442.

Keywords

immunohistochemistry
osteopontin
placenta percrata

Authors

Alev Özer
Aslı Yaylalı
Sezen Koçarslan

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