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The role of osteopontin in the pathogenesis of placenta percreta
- Kahramanmaras Sutcu Imam University, 46000 Kahramanmaras, Türkiye
open access
Abstract
Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by comparing osteopontin expression in normal placentas and placenta percreta tissues.
Material and methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.
Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteopontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).
Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.
Abstract
Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by comparing osteopontin expression in normal placentas and placenta percreta tissues.
Material and methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.
Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteopontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).
Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.
Keywords
immunohistochemistry; osteopontin; placenta percrata
Title
The role of osteopontin in the pathogenesis of placenta percreta
Journal
Issue
Article type
Research paper
Pages
438-442
Published online
2018-08-31
Page views
1867
Article views/downloads
1086
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(8):438-442.
Keywords
immunohistochemistry
osteopontin
placenta percrata
Authors
Alev Özer
Aslı Yaylalı
Sezen Koçarslan
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