open access

Vol 89, No 6 (2018)
Research paper
Published online: 2018-06-29
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Rapid cervical phIGFBP-1 test in asymptomatic twin pregnancies is inefficient in predicting preterm delivery prior to 34 gestational weeks

Katarzyna Kosińska-Kaczyńska1, Iwona Szymusik1, Dorota Bomba-Opoń1, Aleksandra Zyguła1, Mirosław Wielgoś1
·
Pubmed: 30010181
·
Ginekol Pol 2018;89(6):321-325.
Affiliations
  1. 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland

open access

Vol 89, No 6 (2018)
ORIGINAL PAPERS Obstetrics
Published online: 2018-06-29

Abstract

Objectives: To assess the effectiveness of a rapid second trimester test for cervical phIGFBP-1 in the prediction of sponta­neous preterm delivery prior to 34 weeks in asymptomatic twin pregnancies.

Material and methods: A prospective observational study conducted on 232 twin pregnancies tested for phIGFBP-1 at 20–24 weeks of gestation. 151 patients assessed as asymptomatic, with cervical length > 25 mm at 20–24 weeks were analysed. The primary outcome was the delivery < 34 weeks of gestation.

Results: The spontaneous preterm delivery before completing 34 weeks occurred in 23 patients (15.2%), including 9 in dichorionic and 14 in monochorionic pregnancies. The sensitivity of phIGFBP-1 test was 0.39 and specificity 0.63 in predicting delivery before 34 gestational weeks. phIGFBP-1 had a low positive predictive value of 0.16 and high negative predictive value (0.85). Both positive and negative predictive values of delivery < 34 weeks were close to 1.

Conclusions: A test for phIGFBP1 presence is not an effective additional tool for predicting preterm delivery before 34 weeks in twin gestation.

Abstract

Objectives: To assess the effectiveness of a rapid second trimester test for cervical phIGFBP-1 in the prediction of sponta­neous preterm delivery prior to 34 weeks in asymptomatic twin pregnancies.

Material and methods: A prospective observational study conducted on 232 twin pregnancies tested for phIGFBP-1 at 20–24 weeks of gestation. 151 patients assessed as asymptomatic, with cervical length > 25 mm at 20–24 weeks were analysed. The primary outcome was the delivery < 34 weeks of gestation.

Results: The spontaneous preterm delivery before completing 34 weeks occurred in 23 patients (15.2%), including 9 in dichorionic and 14 in monochorionic pregnancies. The sensitivity of phIGFBP-1 test was 0.39 and specificity 0.63 in predicting delivery before 34 gestational weeks. phIGFBP-1 had a low positive predictive value of 0.16 and high negative predictive value (0.85). Both positive and negative predictive values of delivery < 34 weeks were close to 1.

Conclusions: A test for phIGFBP1 presence is not an effective additional tool for predicting preterm delivery before 34 weeks in twin gestation.

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Keywords

twin pregnancy, preterm birth, IGFBP test, preterm delivery screening tests, multiple gestation

About this article
Title

Rapid cervical phIGFBP-1 test in asymptomatic twin pregnancies is inefficient in predicting preterm delivery prior to 34 gestational weeks

Journal

Ginekologia Polska

Issue

Vol 89, No 6 (2018)

Article type

Research paper

Pages

321-325

Published online

2018-06-29

Page views

1191

Article views/downloads

903

DOI

10.5603/GP.a2018.0055

Pubmed

30010181

Bibliographic record

Ginekol Pol 2018;89(6):321-325.

Keywords

twin pregnancy
preterm birth
IGFBP test
preterm delivery screening tests
multiple gestation

Authors

Katarzyna Kosińska-Kaczyńska
Iwona Szymusik
Dorota Bomba-Opoń
Aleksandra Zyguła
Mirosław Wielgoś

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