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Maternal placi protein levels in early- and late-onset preeclampsia
- Dr Nafiz Körez Sincan State Hospital, Ankara, Turkey
- Dr Zekai Tahir Burak Women’s Health Care, Education And Research Hospital, Ankara, Turkey
open access
Abstract
Objectives: The objective of this study was to determine the maternal PLAC1 protein levels in early and late onset preeclampsia.
Material and methods: A total of 135 pregnant women were included in the study, of which 55 were at < 34 weeks of gestation and 80 were at ≥ 34 weeks of gestation, between June and November 2014 were recruited in this case control study.
Results: Analysis of maternal serum PLAC1 levels did not reveal any significant differences between early onset PE and controls (p = 0.422). However, late onset PE patients exhibited significantly elevated levels of PLAC1, in comparison with healthy controls (p = 0.026). The difference in PLAC1 levels between early onset PE and late onset PE was also significant (p = 0.001). Area under ROC curve of PLAC1 for early and late onset PE was 0.563 and 0.646 with p values of 0.422 and 0.026 respectively. Area under ROC curve of PLAC1 in PE was 0.613 with p value = 0.024. The cutoff value for PLAC1 was 6.19 ng/mL with sensitivity: 56% (95% CI 44.1–67.3) and specificity: 63 %; (95% CI 49.9–75.1) and diagnostic odds ratio: 2.2 (95% CI 1.1–4.4) (p value = 0.037). The cutoff value for PLAC1 was 7.2 ng/mL with sensitivity: 43% (95% CI 31.5–54.6) and specificity: 78% (95% CI 65.5–87.5) and diagnostic odds ratio: 2.69 (95% CI 1.25–5.79) (p value = 0.016)
Conclusion: In conclusion, the results of the current study showed that PLAC1 protein levels were significantly elevated in pregnant women with late onset PE in comparison with healthy control group.
Abstract
Objectives: The objective of this study was to determine the maternal PLAC1 protein levels in early and late onset preeclampsia.
Material and methods: A total of 135 pregnant women were included in the study, of which 55 were at < 34 weeks of gestation and 80 were at ≥ 34 weeks of gestation, between June and November 2014 were recruited in this case control study.
Results: Analysis of maternal serum PLAC1 levels did not reveal any significant differences between early onset PE and controls (p = 0.422). However, late onset PE patients exhibited significantly elevated levels of PLAC1, in comparison with healthy controls (p = 0.026). The difference in PLAC1 levels between early onset PE and late onset PE was also significant (p = 0.001). Area under ROC curve of PLAC1 for early and late onset PE was 0.563 and 0.646 with p values of 0.422 and 0.026 respectively. Area under ROC curve of PLAC1 in PE was 0.613 with p value = 0.024. The cutoff value for PLAC1 was 6.19 ng/mL with sensitivity: 56% (95% CI 44.1–67.3) and specificity: 63 %; (95% CI 49.9–75.1) and diagnostic odds ratio: 2.2 (95% CI 1.1–4.4) (p value = 0.037). The cutoff value for PLAC1 was 7.2 ng/mL with sensitivity: 43% (95% CI 31.5–54.6) and specificity: 78% (95% CI 65.5–87.5) and diagnostic odds ratio: 2.69 (95% CI 1.25–5.79) (p value = 0.016)
Conclusion: In conclusion, the results of the current study showed that PLAC1 protein levels were significantly elevated in pregnant women with late onset PE in comparison with healthy control group.
Keywords
pregnancy, maternal serum, PLAC1 protein, Preeclampsia
Title
Maternal placi protein levels in early- and late-onset preeclampsia
Journal
Issue
Article type
Research paper
Pages
147-152
Published online
2018-03-30
Page views
1348
Article views/downloads
1100
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(3):147-152.
Keywords
pregnancy
maternal serum
PLAC1 protein
Preeclampsia
Authors
Mujde Can Ibanoglu
A. Seval Ozgu-Erdinc
Dilek Uygur
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