open access

Vol 89, No 1 (2018)
Research paper
Published online: 2018-01-31
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Neuropilin 1 in uterine leiomyosarcoma. Clinical and pathological analysis

Marcin Bobiński1, Karolina Okła1, Jan Kotarski1, Justyna Szumiło2, Grzegorz Polak1, Małgorzata Sobstyl1, Wiesława Bednarek1
·
Pubmed: 29411340
·
Ginekol Pol 2018;89(1):7-12.
Affiliations
  1. I Chair and Department Of Gynaecological Oncology and Gynaecology Medical University in Lublin, Poland
  2. Chair and Department of Clinical Pathomorphology, Medical University in Lublin, Poland, Poland

open access

Vol 89, No 1 (2018)
ORIGINAL PAPERS Gynecology
Published online: 2018-01-31

Abstract

Objectives: The role of angiogenesis in leiomyosarcomas still remains unclear. The aim of this study was to evaluate the NRP1 expression in the leiomyosarcoma tissues and to find the relations between its expression and the clinical features.

Material and methods: The study group consisted of 50 patients with diagnosis of the uterine leiomyosarcoma. Clinical and follow up data were collected. Using immunohistochemical methods the expression of NRP1 was detected.

Results: The lack of NRP1 expression was found in 14 cases, positive (weak or moderate) expression was noted in 36 cases. The significantly higher expression of NRP1 was observed in more severe clinical stages in comparison to lower stages of the disease. The significantly shorter survival of patients with the positive expression of NRP1 in leiomyosarcoma was observed.

Conclusions: The expression of NRP1 is associated with clinical advancement and worse prognosis in uterine LMS. Neuropilin 1 can be widely used as a postoperative survival predictor for the patients suffering from uterine LMS.

Abstract

Objectives: The role of angiogenesis in leiomyosarcomas still remains unclear. The aim of this study was to evaluate the NRP1 expression in the leiomyosarcoma tissues and to find the relations between its expression and the clinical features.

Material and methods: The study group consisted of 50 patients with diagnosis of the uterine leiomyosarcoma. Clinical and follow up data were collected. Using immunohistochemical methods the expression of NRP1 was detected.

Results: The lack of NRP1 expression was found in 14 cases, positive (weak or moderate) expression was noted in 36 cases. The significantly higher expression of NRP1 was observed in more severe clinical stages in comparison to lower stages of the disease. The significantly shorter survival of patients with the positive expression of NRP1 in leiomyosarcoma was observed.

Conclusions: The expression of NRP1 is associated with clinical advancement and worse prognosis in uterine LMS. Neuropilin 1 can be widely used as a postoperative survival predictor for the patients suffering from uterine LMS.

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Keywords

uterine sarcoma, neuropilin 1, angiogenesis

About this article
Title

Neuropilin 1 in uterine leiomyosarcoma. Clinical and pathological analysis

Journal

Ginekologia Polska

Issue

Vol 89, No 1 (2018)

Article type

Research paper

Pages

7-12

Published online

2018-01-31

Page views

1350

Article views/downloads

1106

DOI

10.5603/GP.a2018.0002

Pubmed

29411340

Bibliographic record

Ginekol Pol 2018;89(1):7-12.

Keywords

uterine sarcoma
neuropilin 1
angiogenesis

Authors

Marcin Bobiński
Karolina Okła
Jan Kotarski
Justyna Szumiło
Grzegorz Polak
Małgorzata Sobstyl
Wiesława Bednarek

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