Vol 89, No 1 (2018)
Research paper
Published online: 2018-01-31
Evaluation of complications developing during and after transvaginal ultrasound — guided oocyte retrieval
Abstract
Objectives: To investigate the complications of the oocyte retrieval procedure currently used in in vitro fertilisation. Material and methods: We examined 1.031 patients who underwent oocyte retrieval in the IVF unit of our hospital for complications developed during and after the procedure. Results: No complications developed related to sedation or general anaesthesia. Vaginal bleeding was observed in 3.1% of the patients. There was no intra-abdominal bleeding or pelvic organ injuries requiring surgery. Two patients developed pelvic abscesses. Ovarian hyperstimulation syndrome (OHSS) occurred in 1.45% of the patients. Almost all of the patients tolerated the oocyte retrieval process well. After the procedure, only 2% of the patients described their pain as severe, and 0.4% as the worst pain they had ever experienced. Conclusions: The most common complication during oocyte retrieval is vaginal bleeding, which is largely controlled by buffer application. In conclusion, the oocyte retrieval process can be considered a safe procedure.
Keywords: In vitro fertilisationoocyte retrievalpost-OR complications
References
- Ditkoff EC, Plumb J, Selick A, et al. Anesthesia practices in the United States common to in vitro fertilization (IVF) centers. J Assist Reprod Genet. 1997; 14(3): 145–147.
- Wickland M, Enk L, Hamberger L. Transvesical and Transvaginal Approaches for the Aspiration of Follicles by Use of Ultrasound. Ann N Y Acad Sci. 1985; 442: 182–194.
- Wikland M, Enk L, Hammarberg K, et al. Use of a vaginal transducer for oocyte retrieval in an IVF/ET program. J Clin Ultrasound. 1987; 15(4): 245–251.
- Hammarberg K, Enk L, Nilsson L, et al. Oocyte retrieval under the guidance of a vaginal transducer: evaluation of patient acceptance. Hum Reprod. 1987; 2(6): 487–490.
- Ludwig AK, Glawatz M, Griesinger G, et al. Perioperative and post-operative complications of transvaginal ultrasound-guided oocyte retrieval: prospective study of >1000 oocyte retrievals. Hum Reprod. 2006; 21(12): 3235–3240.
- Bennett S, Waterstone J, Cheng W, et al. Complications of transvaginal ultrasound-directed follicle aspiration: A review of 2670 consecutive procedures. J Assist Reprod Genet. 1993; 10(1): 7772–7778.
- Govaerts I, Devreker F, Delbaere A, et al. Short-term medical complications of 1500 oocyte retrievals for in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol. 1998; 77(2): 239–243.
- El-Shawarby S, Margara R, Trew G, et al. A review of complications following transvaginal oocyte retrieval for in-vitro fertilization. Hum Fertil (Camb). 2004; 7(2): 127–133.
- Seyhan A, Ata B, Son WY, et al. Comparison of complication rates and pain scores after transvaginal ultrasound-guided oocyte pickup procedures for in vitro maturation and in vitro fertilization cycles. Fertil Steril. 2014; 101(3): 705–709.
- Siristatidis C, Chrelias C, Alexiou A, et al. Clinical complications after transvaginal oocyte retrieval: a retrospective analysis. J Obstet Gynaecol. 2013; 33(1): 64–66.
- Ağrı değerlendirme yöntemleri. In: Güzelemir E. ed. Ağrı ve Te-davisi. Ankara : 11–21.
- Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005; 14(7): 798–804.
- Ayestaran C, Matorras R, Gomez S, et al. Severe bradycardia and bradypnea following vaginal oocyte retrieval: a possible toxic effect of paracervical mepivacaine. Eur J Obstet Gynecol Reprod Biol. 2000; 91(1): 71–73.
- Andersen AN, Gianaroli L, Felberbaum R, et al. European IVF-monitoring programme (EIM), European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE. Hum Reprod. 2005; 20(5): 1158–1176.
- Aragona C, Mohamed MA, Espinola MS, et al. Clinical complications after transvaginal oocyte retrieval in 7,098 IVF cycles. Fertil Steril. 2011; 95(1): 293–294.
- Ragni G, Scarduelli C, Calanna G, et al. Blood loss during transvaginal oocyte retrieval. Gynecol Obstet Invest. 2009; 67(1): 32–35.
- Bennett S, Waterstone J, Parsons J, et al. Two cases of cervical pregnancy following in vitro fertilization and embryo transfer to the lower uterine cavity. J Assist Reprod Genet. 1993; 10(1): 100–103.
- Dicker D, Ashkenazi J, Feldberg D, et al. Severe abdominal complications after transvaginal ultrasonographically guided retrieval of oocytes for in vitro fertilization and embryo transfer. Fertility and Sterility. 1993; 59(6): 1313–1315.
- Dessole S, Rubattu G, Ambrosini G, et al. Blood loss following noncomplicated transvaginal oocyte retrieval for in vitro fertilization. Fertil Steril. 2001; 76(1): 205–206.
- Bentov Y, Levitas E, Silberstein T, et al. Cullen's sign following ultrasound-guided transvaginal oocyte retrieval. Fertil Steril. 2006; 85(1): 227.
- Jayakrishnan K, Raman VK, Vijayalakshmi VK, et al. Massive hematuria with hemodynamic instability - complication of oocyte retrieval. Fertil Steril. 2011; 96(1): e22–e24.
- Bergh T, Lundkvist O. Clinical complications during in-vitro fertilization treatment. Hum Reprod. 1992; 7(5): 625–626.
- Battaglia C, Regnani G, Giulini S, et al. Severe intraabdominal bleeding after transvaginal oocyte retrieval for IVF-ET and coagulation factor XI deficiency: a case report. J Assist Reprod Genet. 2001; 18(3): 178–181.
- El-Shawarby SA, Margara RA, Trew GH, et al. Thrombocythemia and hemoperitoneum after transvaginal oocyte retrieval for in vitro fertilization. Fertil Steril. 2004; 82(3): 735–737.
- Akman MA, Katz E, Damewood MD, et al. Perforated appendicitis and ectopic pregnancy following in-vitro fertilization. Hum Reprod. 1995; 10(12): 3325–3326.
- Roest J, Mous HV, Zeilmaker GH, et al. The incidence of major clinical complications in a Dutch transport IVF programme. Hum Reprod Update. 1996; 2(4): 345–353.
- Bergh T, Lundkvist O. Clinical complications during in-vitro fertilization treatment. Hum Reprod. 1992; 7(5): 625–626.
- Miller PB. Acute ureteral obstruction following transvaginal oocyte retrieval for IVF: Case report. Hum Reprod. 2002; 17(1): 137–138.
- Sarhan A. Surgical complications of in vitro fertilization. Middle East Fertility Society Journal. 2007; 12(1): 1–7.
- Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE. Hum Reprod. 2005; 20(5): 1158–1176.
- Ashkenazi J, Farhi J, Dicker D, et al. Acute pelvic inflammatory disease after oocyte retrieval: adverse effects on the results of implantation. Fertil Steril. 1994; 61(3): 526–528.
- Ludwig AK, Glawatz M, Griesinger G, et al. Perioperative and post-operative complications of transvaginal ultrasound-guided oocyte retrieval: prospective study of >1000 oocyte retrievals. Hum Reprod. 2006; 21(12): 3235–3240.
