open access

Vol 88, No 11 (2017)
ORIGINAL PAPERS Gynecology
Published online: 2017-11-30
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Is M235T polymorphism of the angiotensinogen gene involved in the development of endometriosis?

Liliana J. Kowalczyńska, Tomasz Ferenc, Michał Wojciechowski, Anna Mordalska, Krzysztof Pogoda, Andrzej Malinowski
DOI: 10.5603/GP.a2017.0106
·
Pubmed: 29303211
·
Ginekol Pol 2017;88(11):585-590.

open access

Vol 88, No 11 (2017)
ORIGINAL PAPERS Gynecology
Published online: 2017-11-30

Abstract

Objectives: The aim of the study was to analyze the M235T polymorphism of the angiotensinogen (AGT) gene in women with endometriosis and to identify correlations between identified genotypes and the disease progression, its stage and clinical course as well as to evaluate the prognostic value of the investigated polymorphism in patients with endometriosis treated for infertility.

Material and methods: The study group consisted of 241 women with minimal to severe stage of endometriosis, the control group (without endometriosis) — 127. The molecular analysis was performed by PCR-RFLP technique.

Results: The analysis of the frequency of genotypes and alleles of M235T polymorphism showed no significant differences between the study and the control groups and between the severity grades of the disease (p > 0.05). No such differences were reported in the case of different localizations of the disease lesions, either. Evaluation of the correlations related to pain accompanying endometriosis did not demonstrate association with any genotypes of the analyzed AGT gene poly­morphism. Comparison of the results obtained in the group in which infertility treatment was successful (n = 54) and in those who failed to conceive (n = 73) did not show the correlation between the investigated polymorphism and the effect of infertility treatment.

Conclusions: M235T polymorphism of the AGT gene seems unrelated to the development or the clinical course of en­dometriosis. No prognostic value has been found of the investigated polymorphism in predicting the effects of infertility treatment in women with endometriosis.

Abstract

Objectives: The aim of the study was to analyze the M235T polymorphism of the angiotensinogen (AGT) gene in women with endometriosis and to identify correlations between identified genotypes and the disease progression, its stage and clinical course as well as to evaluate the prognostic value of the investigated polymorphism in patients with endometriosis treated for infertility.

Material and methods: The study group consisted of 241 women with minimal to severe stage of endometriosis, the control group (without endometriosis) — 127. The molecular analysis was performed by PCR-RFLP technique.

Results: The analysis of the frequency of genotypes and alleles of M235T polymorphism showed no significant differences between the study and the control groups and between the severity grades of the disease (p > 0.05). No such differences were reported in the case of different localizations of the disease lesions, either. Evaluation of the correlations related to pain accompanying endometriosis did not demonstrate association with any genotypes of the analyzed AGT gene poly­morphism. Comparison of the results obtained in the group in which infertility treatment was successful (n = 54) and in those who failed to conceive (n = 73) did not show the correlation between the investigated polymorphism and the effect of infertility treatment.

Conclusions: M235T polymorphism of the AGT gene seems unrelated to the development or the clinical course of en­dometriosis. No prognostic value has been found of the investigated polymorphism in predicting the effects of infertility treatment in women with endometriosis.

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Keywords

endometriosis, RAS system, angiotensinogen, gene polymorphism, infertility

About this article
Title

Is M235T polymorphism of the angiotensinogen gene involved in the development of endometriosis?

Journal

Ginekologia Polska

Issue

Vol 88, No 11 (2017)

Pages

585-590

Published online

2017-11-30

DOI

10.5603/GP.a2017.0106

Pubmed

29303211

Bibliographic record

Ginekol Pol 2017;88(11):585-590.

Keywords

endometriosis
RAS system
angiotensinogen
gene polymorphism
infertility

Authors

Liliana J. Kowalczyńska
Tomasz Ferenc
Michał Wojciechowski
Anna Mordalska
Krzysztof Pogoda
Andrzej Malinowski

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