open access
Serum levels of soluble interleukin-2 receptor in association with oxidative stress index in patients with different types of HPV
open access
Abstract
Objectives: The aim of this paper is to determine the oxidative–antioxidative status and levels of soluble interleukin-2 receptor (sIL-2R) in serum of patients with different types of HPV infections and to compare it with patients who are negative for HPV.
Material and methods: A total of 80 women were divided into three groups as follows: Group 1 consisted of 25 women who were positive for HPV types 16 or 18; Group 2 consisted of 25 women who were positive for other types of HPV including type 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68; Group 3 consisted of 30 patients who were negative for HPV as a control group. Serum sIL-2R and plasma oxidative stress index (OSI) were analyzed.
Results: Serum sIL-2R levels were significantly higher in group 1 compared to group 2 and 3. OSI was found significantly increased in groups 1 and 2 compared to group 3. Also, we found a weak positive correlation between IL-2R and OSI.
Conclusion: sIL-2R and oxidative stress may have a role in HPV infection, especially in case of high-risk types.
Abstract
Objectives: The aim of this paper is to determine the oxidative–antioxidative status and levels of soluble interleukin-2 receptor (sIL-2R) in serum of patients with different types of HPV infections and to compare it with patients who are negative for HPV.
Material and methods: A total of 80 women were divided into three groups as follows: Group 1 consisted of 25 women who were positive for HPV types 16 or 18; Group 2 consisted of 25 women who were positive for other types of HPV including type 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68; Group 3 consisted of 30 patients who were negative for HPV as a control group. Serum sIL-2R and plasma oxidative stress index (OSI) were analyzed.
Results: Serum sIL-2R levels were significantly higher in group 1 compared to group 2 and 3. OSI was found significantly increased in groups 1 and 2 compared to group 3. Also, we found a weak positive correlation between IL-2R and OSI.
Conclusion: sIL-2R and oxidative stress may have a role in HPV infection, especially in case of high-risk types.
Keywords
human papillomavirus, total oxidant status, total antioxidant capacity, soluble interleukin-2 receptor
About this articleTitle
Serum levels of soluble interleukin-2 receptor in association with oxidative stress index in patients with different types of HPV
Journal
Issue
Article type
Research paper
Pages
355-359
Published online
2017-07-31
Page views
1351
Article views/downloads
1174
DOI
Pubmed
Bibliographic record
Ginekol Pol 2017;88(7):355-359.
Keywords
human papillomavirus
total oxidant status
total antioxidant capacity
soluble interleukin-2 receptor
Authors
Cenk Nayki
Murat Gunay
Mehmet Kulhan
Umit Nayki
Murat Cankaya
Nur Gozde Kulhan
References (38)- Wright TC, Richart RM. Role of human papillomavirus in the pathogenesis of genital tract warts and cancer. Gynecol Oncol. 1990; 37(2): 151–164.
- Nygård M, Hansen BoT, Dillner J, et al. Targeting human papillomavirus to reduce the burden of cervical, vulvar and vaginal cancer and pre-invasive neoplasia: establishing the baseline for surveillance. PLoS One. 2014; 9(2): e88323.
- Trottier H, Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine. 2006; 24 Suppl 1: S1–15.
- Narisawa-Saito M, Kiyono T. Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci. 2007; 98(10): 1505–1511.
- Senapati R, Senapati NN, Dwibedi B. Molecular mechanisms of HPV mediated neoplastic progression. Infect Agent Cancer. 2016; 11: 59.
- Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev. 2013; 2013: 956792.
- Frazer IH, Tindle RW. Cell-mediated immunity to papillomaviruses. Papillomavirus Report. 1992; 3: 52–58.
- Edwards RP, Kuykendall K, Crowley-Nowick P, et al. T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8-positive cells are recruited to invasion. Cancer. 1995; 76(8): 1411–1415.
- Rubin LA, Nelson DL. The soluble interleukin-2 receptor: biology, function, and clinical application. Ann Intern Med. 1990; 113(8): 245–250.
- Ung A, Kramer TR, Schiffman M, et al. Soluble interleukin 2 receptor levels and cervical neoplasia: results from a population-based case-control study in Costa Rica. Cancer Epidemiol Biomarkers Prev. 1999; 8(3): 249–253.
- Semenzato G, Bambara LM, Biasi D, et al. Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis. J Clin Immunol. 1988; 8(6): 447–452.
- van Steenbergen HW, van Nies JAB, Ruyssen-Witrand A, et al. IL2RA is associated with persistence of rheumatoid arthritis. Arthritis Res Ther. 2015; 17: 244.
- Teraura H, Kotani K, Minami T, et al. The serum concentration of soluble interleukin-2 receptor in patients with Kawasaki disease. Ann Clin Biochem. 2017; 54(2): 209–213.
- Nakamura Y, Tanaka Y, Tanaka M, et al. Soluble interleukin-2 receptor index predicts the development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation from unrelated donors. Int J Hematol. 2016; 103(4): 436–443.
- Kloster BE, John PA, Miller LE, et al. Soluble interleukin 2 receptors are elevated in patients with AIDS or at risk of developing AIDS. Clin Immunol Immunopathol. 1987; 45(3): 440–446.
- Gupta M, Stenson M, O'Byrne M, et al. Comprehensive serum cytokine analysis identifies IL-1RA and soluble IL-2Rα as predictors of event-free survival in T-cell lymphoma. Ann Oncol. 2016; 27(1): 165–172.
- Naumnik W, Chyczewska E, Kovalchuk O, et al. The clinical significance of serum soluble interleukin 2 receptor (sIL-2R) concentration in lung cancer. Folia Histochem Cytobiol. 2001; 39 Suppl 2: 185–186.
- Clerici M, Merola M, Ferrario E, et al. Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection. J Natl Cancer Inst. 1997; 89(3): 245–250.
- Khunamornpong S, Settakorn J, Sukpan K, et al. Performance of HPV DNA testing with hybrid capture 2 in triaging women with minor cervical cytologic abnormalities (ASC-US/LSIL) in Northern Thailand. Asian Pac J Cancer Prev. 2014; 15(24): 10961–10966.
- Verma I, Jain V, Kaur T. Application of bethesda system for cervical cytology in unhealthy cervix. J Clin Diagn Res. 2014; 8(9): OC26–OC30.
- Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38(12): 1103–1111.
- Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004; 37(2): 112–119.
- Demirbag R, Yilmaz R, Erel O, et al. The relationship between potency of oxidative stress and severity of dilated cardiomyopathy. Can J Cardiol. 2005; 21(10): 851–855.
- Looi ML, Mohd Dali AZ, Md Ali SA, et al. Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix. Eur J Cancer Prev. 2008; 17(6): 555–560.
- Kim SY, Kim JW, Ko YS, et al. Changes in lipid peroxidation and antioxidant trace elements in serum of women with cervical intraepithelial neoplasia and invasive cancer. Nutr Cancer. 2003; 47(2): 126–130.
- Gonçalves TL, Erthal F, Corte CLD, et al. Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women. Clin Biochem. 2005; 38(12): 1071–1075.
- Marks MA, Viscidi RP, Chang K, et al. Differences in the concentration and correlation of cervical immune markers among HPV positive and negative perimenopausal women. Cytokine. 2011; 56(3): 798–803.
- Tsukui T, Hildesheim A, Schiffman MH, et al. Interleukin 2 production in vitro by peripheral lymphocytes in response to human papillomavirus-derived peptides: correlation with cervical pathology. Cancer Res. 1996; 56(17): 3967–3974.
- Sharma A, Rajappa M, Saxena A, et al. Cytokine profile in Indian women with cervical intraepithelial neoplasia and cancer cervix. Int J Gynecol Cancer. 2007; 17(4): 879–885.
- Kovacic MB, Katki HA, Kreimer AR, et al. Epidemiologic analysis of histologic cervical inflammation: relationship to human papillomavirus infections. Hum Pathol. 2008; 39(7): 1088–1095.
- Gupta MM, Jain R, Parashari A, et al. Circulating immune profile in patients with pre-cancer and cancer of the cervix: a cross sectional study among Indian women. Bull Cancer. 1993; 80(10): 852–856.
- Ferdeghini M, Gadducci A, Prontera C, et al. Serum soluble interleukin-2 receptor (sIL-2R) assay in cervical and endometrial cancer. Preliminary data. Anticancer Res. 1993; 13(3): 709–713.
- Koumantakis E, Matalliotakis I, Neonaki M, et al. Soluble serum interleukin-2 receptor, interleukin-6 and interleukin-1a in patients with endometriosis and in controls. Arch Gynecol Obstet. 1994; 255(3): 107–112.
- Gadducci A, Ferdeghini M, Malagnino G, et al. Elevated serum levels of neopterin and soluble interleukin-2 receptor in patients with ovarian cancer. Gynecol Oncol. 1994; 52(3): 386–391.
- Hildesheim A, Schiffman MH, Tsukui T, et al. Immune activation in cervical neoplasia: cross-sectional association between plasma soluble interleukin 2 receptor levels and disease. Cancer Epidemiol Biomarkers Prev. 1997; 6(10): 807–813.
- Bais AG, Beckmann I, Lindemans J, et al. A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions. J Clin Pathol. 2005; 58(10): 1096–1100.
- Pardo-Govea T, Callejas D, Núñez-Troconis J, et al. [Gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and interleukins 2, 4 and 6 (IL-2, IL-4, IL-6) in cervical-uterine cells of intraepithelial neoplasia: a preliminary report]. Invest Clin. 2005; 46(1): 5–13.
- Kovacic MB, Katki HA, Kreimer AR, et al. Epidemiologic analysis of histologic cervical inflammation: relationship to human papillomavirus infections. Hum Pathol. 2008; 39(7): 1088–1095.
