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Biological markers with potential clinical value in endometrial cancer — review of the literature
Affiliations- 2nd Department of Gynecology, Medical University of Lublin, Poland, Poland
- 2nd Department of Gynecology, Medical University of Lublin, Poland
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Abstract
Endometrial carcinoma (EC) is the most common malignancy of the female genital tract encountered in western countries, making it the fourth most common cancer in women. The incidence of uterine cancer is on the rise throughout the developed world where diagnosis is increasingly observed among younger patients. With regard to this, attention has been focused on conducting more studies to achieve a better understanding of the molecular genetics related to endometrial carcinogenesis. Over the years, EC has been classified into two broad histopathological subtypes based on the mechanism of development, and we can therefore observe specific biomarkers related to the respective subtype. Based on this idea, more research has been carried out in the last decade, using biotechnological methods, with the aim to identify new potential tumor markers. By translating these findings into clinical use one may facilitate accurate diagnosis and prognostic prediction, and contribute to individualized treatment. Without a doubt, there is a demanding need to identify biomarkers that can be adopted in clinical practice in order to reduce the time needed to obtain diagnosis. Such markers may be of great value in improving patient outcome. However, a number of problems remain to be solved before this becomes a reality. This paper briefly reviews the current status of rising biomarkers in EC.
Abstract
Endometrial carcinoma (EC) is the most common malignancy of the female genital tract encountered in western countries, making it the fourth most common cancer in women. The incidence of uterine cancer is on the rise throughout the developed world where diagnosis is increasingly observed among younger patients. With regard to this, attention has been focused on conducting more studies to achieve a better understanding of the molecular genetics related to endometrial carcinogenesis. Over the years, EC has been classified into two broad histopathological subtypes based on the mechanism of development, and we can therefore observe specific biomarkers related to the respective subtype. Based on this idea, more research has been carried out in the last decade, using biotechnological methods, with the aim to identify new potential tumor markers. By translating these findings into clinical use one may facilitate accurate diagnosis and prognostic prediction, and contribute to individualized treatment. Without a doubt, there is a demanding need to identify biomarkers that can be adopted in clinical practice in order to reduce the time needed to obtain diagnosis. Such markers may be of great value in improving patient outcome. However, a number of problems remain to be solved before this becomes a reality. This paper briefly reviews the current status of rising biomarkers in EC.
Keywords
endometrial cancer, array-based technology, proteomics, gene expression, prognostic markers, screening method
About this articleTitle
Biological markers with potential clinical value in endometrial cancer — review of the literature
Journal
Issue
Article type
Review paper
Pages
331-336
Published online
2017-06-30
Page views
2059
Article views/downloads
2412
DOI
Pubmed
Bibliographic record
Ginekol Pol 2017;88(6):331-336.
Keywords
endometrial cancer
array-based technology
proteomics
gene expression
prognostic markers
screening method
Authors
Nadia Taoussi
Ali Alghamdi
Konrad Futyma
Tomasz Rechberger
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